| PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage. | PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage.
Hanaki S, Habara M, Masaki T, Maeda K, Sato Y, Nakanishi M, Shimada M., Free PMC Article | 07/10/2021 |
| PP1-NIPP1 expression resulted in the build up of RNA-DNA hybrids (R-loops), enhanced chromatin compaction and a diminished repair of DNA double-strand breaks. | Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.
Winkler C, Rouget R, Wu D, Beullens M, Van Eynde A, Bollen M. | 11/23/2019 |
| NIPP1 could be activated by hypoxia and contributed to hypoxia-induced invasive and metastatic potential in hepatocellular carcinoma. | Hypoxia-induced NIPP1 activation enhances metastatic potential and predicts poor prognosis in hepatocellular carcinoma.
Huang Y, Tao Y, Hu K, Lin F, Li X, Feng T, Wang ZM. | 03/4/2017 |
| Data suggest overexpression of NIPP1 in HeLa cells causes induction of genes of mesenchymal lineage with reduction in cell proliferation; thus, key dephosphorylation events may be involved in epithelial-mesenchymal transition or transdifferentiation. | Protein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells.
Van Dessel N, Boens S, Lesage B, Winkler C, Görnemann J, Van Eynde A, Bollen M. | 08/1/2015 |
| PP1/NIPP1 is a novel molecular compass that controls directed cell migration. | A role for PP1/NIPP1 in steering migration of human cancer cells.
Martin-Granados C, Prescott AR, Van Dessel N, Van Eynde A, Arocena M, Klaska IP, Görnemann J, Beullens M, Bollen M, Forrester JV, McCaig CD., Free PMC Article | 03/23/2013 |
| The molecular basis by which NIPP1 directs PP1 substrate specificity in the nucleus. | The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme.
O'Connell N, Nichols SR, Heroes E, Beullens M, Bollen M, Peti W, Page R., Free PMC Article | 03/23/2013 |
| NIPP1 works as a molecular sensor for PP1 to recognize phosphorylated Sap155. | Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155).
Tanuma N, Kim SE, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H. | 01/21/2010 |
| NMR structure of the NIPP1 FHA domain. | The NMR structure of the NIPP1 FHA domain.
Kumeta H, Ogura K, Adachi S, Fujioka Y, Tanuma N, Kikuchi K, Inagaki F. | 01/21/2010 |
| Required for the global trimethylation of histone3 at lysine27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2. | The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing.
Nuytten M, Beke L, Van Eynde A, Ceulemans H, Beullens M, Van Hummelen P, Fuks F, Bollen M. | 01/21/2010 |
| NIPP1 is present in a complex with EED and EZH2 in vivo and has distinct binding sites for these proteins. | The transcriptional repression by NIPP1 is mediated by Polycomb group proteins.
Roy N, Van Eynde A, Beke L, Nuytten M, Bollen M. | 01/21/2010 |
| NIPP1 has a role in the nuclear targeting and/or retention of PP1 | Interactor-mediated nuclear translocation and retention of protein phosphatase-1.
Lesage B, Beullens M, Nuytten M, Van Eynde A, Keppens S, Himpens B, Bollen M. | 01/21/2010 |
| The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly | The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly.
Beullens M, Bollen M. | 01/21/2010 |
| We demonstrate that interaction with NIPP1 mediates decreased PP1gamma activity in hypoxia, an event which may constitute an inherent part of the cellular oxygen-sensing machinery and may play a role in physiologic adaptation to hypoxia. | Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism.
Comerford KM, Leonard MO, Cummins EP, Fitzgerald KT, Beullens M, Bollen M, Taylor CT. | 01/21/2010 |