| PSPC1 Binds to HCV IRES and Prevents Ribosomal Protein S5 Binding, Inhibiting Viral RNA Translation. | PSPC1 Binds to HCV IRES and Prevents Ribosomal Protein S5 Binding, Inhibiting Viral RNA Translation.
Tripathi SK, Aneja A, Borgaonkar T, Das S., Free PMC Article | 08/7/2024 |
| Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer. | Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer.
Lemster AL, Weingart A, Bottner J, Perner S, Sailer V, Offermann A, Kirfel J. | 08/16/2023 |
| Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation. | Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation.
Cubillos-Zapata C, Martínez-García MÁ, Díaz-García E, García-Tovar S, Campos-Rodríguez F, Sánchez-de-la-Torre M, Nagore E, Martorell-Calatayud A, Blasco LH, Pastor E, Abad-Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Arias E, Mediano O, Somoza-González M, Dalmau-Arias J, Almendros I, Farré R, Gozal D, García-Río F, Spanish Sleep Network. | 02/10/2023 |
| PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2. | PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2.
Takeiwa T, Ikeda K, Suzuki T, Sato W, Iino K, Mitobe Y, Kawabata H, Horie K, Inoue S., Free PMC Article | 06/18/2022 |
| Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. | Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells.
Mohankumar K, Shrestha R, Safe S., Free PMC Article | 12/25/2021 |
| PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. | PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility.
Jen HW, Gu DL, Lang YD, Jou YS., Free PMC Article | 03/6/2021 |
| Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS. | Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS.
Tyzack GE, Manferrari G, Newcombe J, Luscombe NM, Luisier R, Patani R., Free PMC Article | 01/2/2021 |
| PSPC1, a nuclear substrate of PTK6, sequesters PTK6 in the nucleus and loses its metastasis driving capability in hepatocellular carcinoma. Conversely, PSPC1 upregulation or PSPC1-Y523F mutation promotes epithelial-mesenchymal transition, stemness, and metastasis via cytoplasmic translocation of active PTK6 and nuclear translocation of beta-catenin, which interacts with PSPC1 to augment Wnt3a autocrine signaling. | PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression.
Lang YD, Chen HY, Ho CM, Shih JH, Hsu EC, Shen R, Lee YC, Chen JW, Wu CY, Yeh HW, Chen RH, Jou YS., Free PMC Article | 04/4/2020 |
| This study determined that Hepatitis Delta Virus replication induces the delocalization of PSP1 to cytoplasmic foci containing PABP and increases NEAT1 level causing an enlargement of NEAT1 foci. | The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization.
Beeharry Y, Goodrum G, Imperiale CJ, Pelchat M., Free PMC Article | 10/5/2019 |
| PSPC1 and TET2 contribute to ERVL and ERVL-associated gene regulation by both transcriptional repression via histone deacetylases and post-transcriptional destabilization of RNAs through 5hmC modification. | RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells.
Guallar D, Bi X, Pardavila JA, Huang X, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelley K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, Wang J., Free PMC Article | 05/11/2019 |
| PSPC1 increases transforming growth factor-beta1 (TGF-beta1) secretion through an interaction with phosphorylated and nuclear Smad2/3 to potentiate TGF-beta1 autocrine signaling, promoting epithelial mesenchymal transformation, stemness and metastasis. | PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis.
Yeh HW, Hsu EC, Lee SS, Lang YD, Lin YC, Chang CY, Lee SY, Gu DL, Shih JH, Ho CM, Chen CF, Chen CT, Tu PH, Cheng CF, Chen RH, Yang RB, Jou YS. | 04/20/2019 |
| Analytical ultracentrifugation to estimate the dimerization equilibrium of the SFPQ-containing dimers revealed that the SFPQ-containing dimers dissociate at low micromolar concentrations and that the heterodimers have higher affinities than the homodimer. Moreover, we observed that the apparent dissociation constant for the SFPQ/PSPC1 heterodimer was over 6-fold lower than that of the SFPQ/NONO heterodimer. | Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins.
Huang J, Casas Garcia GP, Perugini MA, Fox AH, Bond CS, Lee M., Free PMC Article | 12/29/2018 |
| Development of a pipeline for automated, high-throughput analysis of PSPC1 paraspeckle protein isoforms reveals specific roles for IMPa2, IMPa4 and IMPa6 proteins. | Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins.
Major AT, Miyamoto Y, Lo CY, Jans DA, Loveland KL., Free PMC Article | 11/3/2018 |
| The crystal structure of the heterodimer of the multidomain conserved region of the Drosophila behavior/human splicing proteins, PSPC1 and NONO, is described. | Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.
Passon DM, Lee M, Rackham O, Stanley WA, Sadowska A, Filipovska A, Fox AH, Bond CS., Free PMC Article | 05/26/2012 |
| downregulated were the a protein coding gene PSPC1 in breast and ovarian cancer cells | LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation.
Silva JM, Boczek NJ, Berres MW, Ma X, Smith DI. | 05/19/2012 |
| crystal of PSPC1-NONO contained one heterodimer in the asymmetric unit and diffracted to 1.9 A resolution using synchrotron radiation | Crystallization of a paraspeckle protein PSPC1-NONO heterodimer.
Passon DM, Lee M, Fox AH, Bond CS., Free PMC Article | 02/4/2012 |
| We map the domain within PSP1 that is mediating this interaction and show it is required for the correct localization of PSP1 to paraspeckles. This interaction is necessary but not sufficient for paraspeckle targeting by PSP1 | P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner.
Fox AH, Bond CS, Lamond AI., Free PMC Article | 01/21/2010 |