| Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression. | Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression.
Bayramova DO, Azieva AM, Feoktistov AV, Georgieva SG, Soshnikova NV., Free PMC Article | 04/22/2024 |
| ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer. | ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer.
Huang C, Zhou S, Zhang C, Jin Y, Xu G, Zhou L, Ding G, Pang T, Jia S, Cao L. | 03/12/2022 |
| PHF10 subunit of PBAF complex mediates transcriptional activation by MYC. | PHF10 subunit of PBAF complex mediates transcriptional activation by MYC.
Soshnikova NV, Tatarskiy EV, Tatarskiy VV, Klimenko NS, Shtil AA, Nikiforov MA, Georgieva SG., Free PMC Article | 01/1/2022 |
| The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms. | The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms.
Sheynov AA, Tatarskiy VV Jr, Tatarskiy EV, Nabirochkina EN, Georgieva SG, Soshnikova NV., Free PMC Article | 08/28/2021 |
| PHF10 expression in cells of different lines is activated by the c-MYC oncogene. Since PHF10 stimulates cell proliferation, its c-MYC-dependent activation in cancer cells should lead to an increase in their proliferation rate. | Oncogene c-MYC Controls the Expression of PHF10 Subunit of PBAF Chromatin Remodeling Complex in SW620 Cell Line.
Tatarskiy EV, Georgiev GP, Soshnikova NV. | 05/4/2019 |
| Data show that PHF10 subunit of the PBAF signature module is the most unstable PBAF subunit, and demonstrate an important role of beta-TrCP ubiquitin ligase in regulation of PHF10 level and PBAF in general. Also, PHF10 isoforms contained two non-canonical beta-TrCP degrons and are degraded by beta-TrCP in a phospho-dependent manner. | Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP.
Tatarskiy VV, Simonov YP, Shcherbinin DS, Brechalov AV, Georgieva SG, Soshnikova NV., Free PMC Article | 01/26/2019 |
| We studied the expression of S100A4 and the total PHF10 protein in some human cancer cell lines. We have found that, in the cell lines studied, the PHF10 expression is correlated with the S100A4 expression. | The level of the Phf10 protein, a PBAF chromatin-remodeling complex subunit, correlates with the Mts1/S100A4 expression in human cancer cell lines.
Soshnikova NV, Simonov YP, Brechalov AV, Portseva TN, Pankratova EV, Georgieva SG. | 02/4/2017 |
| Phosphorylation of PHF10 isoforms occurs while they are incorporated as a subunit of the PBAF complex, and therefore phosphorylation of PHF10 isoforms may play an essential role in regulation of PBAF complex's function and mechanism of action. | [PHF10 isoforms are phosphorylated in the PBAF mammalian chromatin remodeling complex].
Brechalov AV, Valieva ME, Georgieva SG, Soshnikova NV. | 07/2/2016 |
| The study demonstrates the existence of functionally different PBAF complexes in mammalian cell. It also provides an insight into the molecular structure and role of human PHF10/BAF45a and characterizes it as an essential PBAF subunit. | Mammalian cells contain two functionally distinct PBAF complexes incorporating different isoforms of PHF10 signature subunit.
Brechalov AV, Georgieva SG, Soshnikova NV., Free PMC Article | 01/24/2015 |
| PHF10 repressed caspase-3 expression and impaired the programmed cell death pathway in human gastric cancer at the transcriptional level. | A novel plant homeodomain finger 10-mediated antiapoptotic mechanism involving repression of caspase-3 in gastric cancer cells.
Wei M, Liu B, Su L, Li J, Zhang J, Yu Y, Yan M, Yang Z, Chen X, Liu J, Lv X, Nie H, Zhang Q, Zheng Z, Yu B, Ji J, Zhang J, Zhu Z, Gu Q. | 09/20/2010 |
| Data show that that PHF10 is required for cell growth. | PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cells.
Banga SS, Peng L, Dasgupta T, Palejwala V, Ozer HL., Free PMC Article | 02/15/2010 |