| A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma. | A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma.
Cabarcas-Petroski S, Meneses PI, Schramm L., Free PMC Article | 05/15/2021 |
| TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma. | TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma.
Sui R, Liu C, Wang N, Fan X, Han S, Zhang J, Hou L, Zhang X, Xu A. | 05/8/2021 |
| Silencing of BRF2 inhibits the growth and metastasis of lung cancer cells. | Silencing of BRF2 inhibits the growth and metastasis of lung cancer cells.
Bian Y, Li Q, Li Q, Pan R., Free PMC Article | 04/24/2021 |
| MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2. | MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2.
Yu X, Zheng H, Sun R, Qian X, Jiang P, Yang B, Liu J, Li X., Free PMC Article | 09/26/2020 |
| This study found a novel signaling pathway, namely MNX1-AS1/miR-527/BRF2 axis, involved in lung cancer progression. | Long noncoding RNA MNX1-AS1 contributes to lung cancer progression through the miR-527/BRF2 pathway.
Liu H, Han L, Liu Z, Gao N. | 05/23/2020 |
| Results show that the mRNA and protein expression levels of BRF2 were markedly higher in non-small cell lung cancer (NSCLC) cells and highly related to differentiation degree, lymph node metastasis, clinical stage, and vascular invasion. miR-373 was identified to directly target BRF2, resulting in the enhanced migration and invasion of NSCLC A549 cells and indicating that BRF2 affects the metastasis of NSCLC. | MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line.
Wang L, Qu J, Zhou L, Liao F, Wang J., Free PMC Article | 10/27/2018 |
| REVIEW: highlights the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations | New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.
Gouge J, Vannini A., Free PMC Article | 10/20/2018 |
| Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter. | Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.
Gouge J, Guthertz N, Kramm K, Dergai O, Abascal-Palacios G, Satia K, Cousin P, Hernandez N, Grohmann D, Vannini A., Free PMC Article | 11/18/2017 |
| Study solved crystal structures of a human Brf2-TATA-binding complex bound to natural promoters, obtaining a detailed view of the molecular interactions occurring at Brf2-dependent Pol III promoters and highlighting the general structural and functional conservation of human Pol II and Pol III pre-initiation complexes. | Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.
Gouge J, Satia K, Guthertz N, Widya M, Thompson AJ, Cousin P, Dergai O, Hernandez N, Vannini A., Free PMC Article | 04/9/2016 |
| hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. | hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
Reznik B, Clement SL, Lykke-Andersen J., Free PMC Article | 02/21/2015 |
| These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program. | TFIIB-related factor 2 is associated with poor prognosis of nonsmall cell lung cancer patients through promoting tumor epithelial-mesenchymal transition.
Tian Y, Lu M, Yue W, Li L, Li S, Gao C, Si L, Qi L, Hu W, Tian H., Free PMC Article | 12/20/2014 |
| BRF2 may have a role in poor prognosis and anti-angiogenic therapy for early-stage non-small cell lung cancer | TFIIB-related factor 2 over expression is a prognosis marker for early-stage non-small cell lung cancer correlated with tumor angiogenesis.
Lu M, Tian H, Yue W, Li L, Li S, Qi L, Hu W, Gao C, Si L., Free PMC Article | 11/8/2014 |
| High expression of BRF2 is closely associated with tumor progression, angiogenesis, and poor survival in esophageal squamous cell cancer. | Overexpression of TFIIB-related factor 2 is significantly correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer.
Lu M, Tian H, Yue W, Li L, Li S, Qi L, Hu W, Gao C, Si L. | 10/26/2013 |
| BRF2 can serve as a marker for lung squamous cell carcinoma and may provide a novel target for therapy. | Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.
Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell J, Williams AC, Hwang D, Zhu CQ, Buys TP, Yee J, English JC, Macaulay C, Tsao MS, Gazdar AF, Minna JD, Lam S, Lam WL., Free PMC Article | 11/6/2010 |
| deregulation of Brf1 and Brf2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells | Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.
Cabarcas S, Jacob J, Veras I, Schramm L., Free PMC Article | 01/21/2010 |
| C-terminal domain of Brf2 is required for efficient association of the protein with U6 promoter-bound TBP and SNAP(c), a type 3 promoter-specific transcription factor, and for efficient recruitment of Bdp1 | Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription.
Saxena A, Ma B, Schramm L, Hernandez N., Free PMC Article | 01/21/2010 |