| Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases. | Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases.
Yi JK, Xu R, Obeid LM, Hannun YA, Airola MV, Mao C., Free PMC Article | 09/17/2022 |
| LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI. | LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI.
Chen W, Wang F, Zhang J, Li C, Hong L., Free PMC Article | 03/19/2022 |
| Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p. | Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p.
Bai K, Ma Y, Li J., Free PMC Article | 02/26/2022 |
| ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants. | ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants.
Dehnavi AZ, Heidari E, Rasulinezhad M, Heidari M, Ashrafi MR, Hosseini MM, Sadeghzadeh F, Fallah MS, Rostampour N, Bahraini A, Garshasbi M, Tavasoli AR., Free PMC Article | 02/5/2022 |
| Our study suggests that Acer3 contributes to hepatocellular carcinoma propagation | Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Yin Y, Xu M, Gao J, Li M. | 11/17/2018 |
| Homozygosity for the p.E33G mutation in the ACER3 gene results in inactivation of ACER3. | Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy.
Edvardson S, Yi JK, Jalas C, Xu R, Webb BD, Snider J, Fedick A, Kleinman E, Treff NR, Mao C, Elpeleg O., Free PMC Article | 11/4/2017 |
| The ACER3 deficiency resulted in decreased cell growth and colony formation, elevated apoptosis, and lower AKT signaling of leukemia cells. This study indicates that ACER3 contributes to AML pathogenesis, and suggests that alkaline ceramidase inhibition is an option to treat acute myeloid leukemia. | ACER3 supports development of acute myeloid leukemia.
Chen C, Yin Y, Li C, Chen J, Xie J, Lu Z, Li M, Wang Y, Zhang CC. | 06/3/2017 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| ACER3 catalyzes the hydrolysis of unsaturated long chain ceramides and dihydroceramides and coordinates with ACER2 to regulate cell proliferation and survival | Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis.
Hu W, Xu R, Sun W, Szulc ZM, Bielawski J, Obeid LM, Mao C., Free PMC Article | 04/19/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. | 12/2/2009 |