| Cancer cell-derived exosomes promote NSCLC progression via the miR-199b-5p/HIF1AN axis. | Cancer cell-derived exosomes promote NSCLC progression via the miR-199b-5p/HIF1AN axis.
Liu B, Rui Y, Li M, Huang L. | 10/30/2024 |
| Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation. | Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation.
Li N, Zhou Q, Yi Z, Zhang H, Zhou D., Free PMC Article | 02/11/2023 |
| The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor. | The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor.
Volkova YL, Pickel C, Jucht AE, Wenger RH, Scholz CC. | 11/12/2022 |
| Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins. | Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins.
Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Feng T, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, Schofield CJ., Free PMC Article | 07/2/2022 |
| High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases. | High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases.
Sharma K, Mishra A, Singh HN, Parashar D, Alam P, Thinlas T, Mohammad G, Kukreti R, Syed MA, Pasha MAQ. | 04/2/2022 |
| TMEM161B-AS1 suppresses proliferation, invasion and glycolysis by targeting miR-23a-3p/HIF1AN signal axis in oesophageal squamous cell carcinoma. | TMEM161B-AS1 suppresses proliferation, invasion and glycolysis by targeting miR-23a-3p/HIF1AN signal axis in oesophageal squamous cell carcinoma.
Shi Z, Li G, Li Z, Liu J, Tang Y., Free PMC Article | 02/5/2022 |
| CASC2 inhibits the growth, migration, and invasion of thyroid cancer cells through sponging miR-18a-5p/FIH1 axis. | CASC2 inhibits the growth, migration, and invasion of thyroid cancer cells through sponging miR-18a-5p/FIH1 axis.
Liu QY, Gao LY, Xu L, Zhang XL, Zhang LJ, Gong XL, Luo SB, Zhao R, Cheng RC. | 12/4/2021 |
| miR212 promotes renal interstitial fibrosis by inhibiting hypoxiainducible factor 1alpha inhibitor. | miR‑212 promotes renal interstitial fibrosis by inhibiting hypoxia‑inducible factor 1‑α inhibitor.
Zhang Y, Zhang GX, Che LS, Shi SH, Li YT., Free PMC Article | 05/8/2021 |
| Authors provide evidence, based on the application of genetic interventions and small molecule inhibition of the HIF hydroxylases, that the nuclear localization of FIH is governed by two opposing processes: nuclear entry by 'coupling' with HIF1alpha for importin beta1-mediated nuclear import and active export via a Leptomycin B-sensitive exportin1-dependent pathway. | Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively.
Wang Y, Zhong S, Schofield CJ, Ratcliffe PJ, Lu X., Free PMC Article | 01/11/2020 |
| Low FIH expression is associated with lung cancer. | MicroRNA-31-5p enhances the Warburg effect via targeting FIH.
Zhu B, Cao X, Zhang W, Pan G, Yi Q, Zhong W, Yan D. | 07/13/2019 |
| ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1alpha by upregulating FIH1. ANKDD1A decreases the half-life of HIF1alpha by upregulating FIH1, decreases glucose uptake and lactate production, inhibits glioblastoma multiforme (GBM) autophagy, and induces apoptosis in GBM cells under hypoxia | Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment.
Feng J, Zhang Y, She X, Sun Y, Fan L, Ren X, Fu H, Liu C, Li P, Zhao C, Liu Q, Liu Q, Li G, Wu M., Free PMC Article | 03/16/2019 |
| High FIH expression is associated with Ovarian Cancer metastasis. | FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes.
Kang J, Shin SH, Yoon H, Huh J, Shin HW, Chun YS, Park JW. | 01/19/2019 |
| FIH-1 plasmid transfection decreased the cell proliferation of OS-RC-2 renal carcinoma cells,but did not show inhibition on 786-0 cell proliferation | [Growth Regulation of Factor Inhibiting Hypoxia-Inducible Factor in Renal Carcinoma Cells].
Deng S, Yang B, Ren ZJ, Dong Q. | 01/12/2019 |
| Since the FIH-1 dependent hydroxylation of NAA10 occurs oxygen-dependently, NAA10 acetylates HIF-1alpha under normoxia but does not under hypoxia. | FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α.
Kang J, Chun YS, Huh J, Park JW., Free PMC Article | 12/22/2018 |
| Authors identified KANK3 as a new substrate for the oxygen sensor hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), which hydroxylates HIF-1/2alpha and other ankyrin repeat domain-containing proteins at asparagine residues. | A novel HIF1AN substrate KANK3 plays a tumor-suppressive role in hepatocellular carcinoma.
Kim I, Kang J, Gee HY, Park JW. | 08/18/2018 |
| MiR-31-5p plays an important role in HS formation by inhibiting FIH and regulating the HIF-1alpha pathway. | Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism.
Wang X, Zhang Y, Jiang BH, Zhang Q, Zhou RP, Zhang L, Wang C. | 12/2/2017 |
| Low FIH1 expression is associated with chemotherapy resistance in breast cancer. | MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer.
Roscigno G, Puoti I, Giordano I, Donnarumma E, Russo V, Affinito A, Adamo A, Quintavalle C, Todaro M, Vivanco MD, Condorelli G., Free PMC Article | 10/14/2017 |
| data support a model in which the facial triad carboxylate Asp(201) provides both steric and polar contacts to favor O2 access to the Fe(II) only after substrate binds, leading to coupled turnover in FIH and other alphaKG oxygenases. | The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O(2) activation.
Hangasky JA, Taabazuing CY, Martin CB, Eron SJ, Knapp MJ., Free PMC Article | 09/9/2017 |
| None of the clinicopathological parameters were associated with the expressions of FIH-1 and SOCS3 at mRNA level. | Investigation of FIH-1 and SOCS3 expression in KRAS mutant and wild-type patients with colorectal cancer.
Vakil L, Najafipour R, Rakhshani N, Zamani F, Morakabati A, Javadi A. | 02/4/2017 |
| This study provides novel clues indicating that miR-21, miR-31, and miR-184 co-target FIH tumor suppressor during pathogenesis in the vast majority of head and neck squamous cell carcinoma. | Co-targeting of multiple microRNAs on factor-Inhibiting hypoxia-Inducible factor gene for the pathogenesis of head and neck carcinomas.
Kao SY, Tsai MM, Wu CH, Chen JJ, Tseng SH, Lin SC, Chang KW. | 01/28/2017 |
| Results suggest that NECAB3, a novel Mint3-binding protein, activates HIF-1 to promote normoxic glycolysis and tumorigenicity by forming a ternary complex with Mint3 and FIH-1. | NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells.
Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T., Free PMC Article | 01/28/2017 |
| the levels of both miR-182 and HIF1alpha were elevated, while the expression PHD2 and FIH1 was downregulated in a mouse model of prostate cancer. | Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer.
Li Y, Zhang D, Wang X, Yao X, Ye C, Zhang S, Wang H, Chang C, Xia H, Wang YC, Fang J, Yan J, Ying H., Free PMC Article | 08/6/2016 |
| OTUB1 is a target for functional hydroxylation by FIH. | FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
Scholz CC, Rodriguez J, Pickel C, Burr S, Fabrizio JA, Nolan KA, Spielmann P, Cavadas MA, Crifo B, Halligan DN, Nathan JA, Peet DJ, Wenger RH, Von Kriegsheim A, Cummins EP, Taylor CT., Free PMC Article | 06/11/2016 |
| demonstrates that miR-135b regulates ERalpha, AR and HIF1AN protein levels through interaction with their 3'UTR regions, and proliferation in ERalpha-positive BCa and AR-positive PCa cells | MicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth.
Aakula A, Leivonen SK, Hintsanen P, Aittokallio T, Ceder Y, Børresen-Dale AL, Perälä M, Östling P, Kallioniemi O., Free PMC Article | 06/4/2016 |
| Hypoxia, FIH inhibitors and mutation of asparagine 242 all potentiated TRPV3-mediated current, without altering TRPV3 protein levels, indicating that oxygen-dependent hydroxylation inhibits TRPV3 activity. | Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.
Karttunen S, Duffield M, Scrimgeour NR, Squires L, Lim WL, Dallas ML, Scragg JL, Chicher J, Dave KA, Whitelaw ML, Peers C, Gorman JJ, Gleadle JM, Rychkov GY, Peet DJ. | 03/5/2016 |