| The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD. | The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD.
Halim DO, Krishnan G, Hass EP, Lee S, Verma M, Almeida S, Gu Y, Kwon DY, Fazzio TG, Gao FB., Free PMC Article | 07/31/2024 |
| Mutations in the exocyst component EXOC2 cause severe defects in human brain development. | Mutations in the exocyst component EXOC2 cause severe defects in human brain development.
Van Bergen NJ, Ahmed SM, Collins F, Cowley M, Vetro A, Dale RC, Hock DH, de Caestecker C, Menezes M, Massey S, Ho G, Pisano T, Glover S, Gusman J, Stroud DA, Dinger M, Guerrini R, Macara IG, Christodoulou J., Free PMC Article | 05/15/2021 |
| data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites. | Dexamethasone-induced cellular tension requires a SGK1-stimulated Sec5-GEF-H1 interaction.
Wang HL, Yang CH, Lee HH, Kuo JC, Hur SS, Chien S, Lee OK, Hung SC, Chang ZF. | 08/27/2016 |
| Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. | Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.
Xie L, Zhu D, Kang Y, Liang T, He Y, Gaisano HY., Free PMC Article | 01/25/2014 |
| We identified interactions between RalA and its effectors sec5 and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. | Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.
Hazelett CC, Yeaman C., Free PMC Article | 03/23/2013 |
| Data show that Mc1R, HERC2, IRF4, TYR and EXOC2 are ranked highest in hair color prediction analysis. | Model-based prediction of human hair color using DNA variants.
Branicki W, Liu F, van Duijn K, Draus-Barini J, Pośpiech E, Walsh S, Kupiec T, Wojas-Pelc A, Kayser M., Free PMC Article | 06/18/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genetic differences between five European populations.
Moskvina V, Smith M, Ivanov D, Blackwood D, StClair D, Hultman C, Toncheva D, Gill M, Corvin A, O'Dushlaine C, Morris DW, Wray NR, Sullivan P, Pato C, Pato MT, Sklar P, Purcell S, Holmans P, O'Donovan MC, Owen MJ, Kirov G, International Schizophrenia Consortium., Free PMC Article | 09/15/2010 |
| Genome-wide association study of gene-disease association. (HuGE Navigator) | Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI, International IBD Genetics Consortium., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells. | Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.
Issaq SH, Lim KH, Counter CM., Free PMC Article | 06/28/2010 |
| Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin. | Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.
Spiczka KS, Yeaman C., Free PMC Article | 01/21/2010 |
| SEC5 has been identified as a binding partner of deafness locus putative guanine nucleotide exchange factor. | DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.
Sjölinder M, Uhlmann J, Ponstingl H. | 01/21/2010 |
| evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 | Ral GTPases regulate exocyst assembly through dual subunit interactions.
Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA. | 01/21/2010 |
| These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. | RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L, Gale M Jr, Yeaman C, Camonis JH, Zhao Y, White MA. | 01/21/2010 |
| Functional study of the Drosophila homolog. | Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists.
Murthy M, Garza D, Scheller RH, Schwarz TL. | 04/25/2003 |