| Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity. | Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.
Zhang Z, Xu X, Zhang D, Zhao S, Wang C, Zhang G, Chen W, Liu J, Gong H, Rixiati Y, Li S, Shen T, Li J. | 03/11/2024 |
| Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma. | Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.
Peng X, Zhao L, Yao L, Dong J, Wu W, Luo T., Free PMC Article | 07/19/2023 |
| Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer. | Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer.
Shen T, Liu JL, Wang CY, Rixiati Y, Li S, Cai LD, Zhao YY, Li JM., Free PMC Article | 03/12/2022 |
| The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease. | The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease.
Jang H, Stevens P, Gao T, Galperin E., Free PMC Article | 07/31/2021 |
| Findings show that ERBIN is required for Dsg1 requires to downregulate EGFR/Erk signaling and fully suppress invadopodia formation. | Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner.
Valenzuela-Iglesias A, Burks HE, Arnette CR, Yalamanchili A, Nekrasova O, Godsel LM, Green KJ., Free PMC Article | 05/2/2020 |
| Erbin is mainly localized in endothelial cells in human umbilical veins and plays a critical role in endothelial cell migration and tubular formation via the Smad1/5 pathway. | Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.
Jin X, Li B, Zhao Y, Liu X, Li Y, Song L, Cui L, Xie D, Li T, Zhang X, Guo Y. | 03/21/2020 |
| Erbin interacted with kinase suppressor of Ras 1 (KSR1) and displaced it from the RAF/MEK/ERK complex to prevent signal propagation..These findings establish the scaffold protein Erbin as a negative regulator of EMT and tumorigenesis in colorectal cancer through direct suppression of Akt and RAS/RAF signaling | Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
Stevens PD, Wen YA, Xiong X, Zaytseva YY, Li AT, Wang C, Stevens AT, Farmer TN, Gan T, Weiss HL, Inagaki M, Marchetto S, Borg JP, Gao T., Free PMC Article | 09/21/2019 |
| Erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1. | LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis.
Zhang L, Wang L, Wang Y, Chen T, Liu R, Yang W, Liu Q, Tu K. | 03/30/2019 |
| miR-23c inhibited cell proliferation and accelerated apoptosis by attenuating ERBB2IP. | miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP.
Zhang L, Wang Y, Wang L, Yin G, Li W, Xian Y, Yang W, Liu Q. | 01/19/2019 |
| Our data uncovered an important role of Erbin in regulating hepatocellular carcinoma (HCC) tumorigenesis through inactivating ERalpha-mediated tumor-suppressive signaling, suggesting a new strategy for tamoxifen therapy in HCC by targeting Erbin/ERalpha signaling axis. | Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis in hepatocellular carcinoma.
Wu H, Yao S, Zhang S, Wang JR, Guo PD, Li XM, Gan WJ, Mei L, Gao TM, Li JM. | 03/24/2018 |
| STAT3 activation promotes ERBIN expression and negatively regulates TGF-beta activity by the formation of a STAT3-ERBIN-SMAD2/3 complex. | ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.
Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD., Free PMC Article | 08/19/2017 |
| Erbin loss accelerates cell cycle though down-regulating p21 and p27 expression. Erbin is a novel negative modulator of Akt1-Skp2-p27 signaling pathway. | Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling.
Huang H, Song Y, Wu Y, Guo N, Ma Y, Qian L. | 09/12/2015 |
| Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor | Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR.
Yao S, Zheng P, Wu H, Song LM, Ying XF, Xing C, Li Y, Xiao ZQ, Zhou XN, Shen T, Chen L, Liu YH, Lai MD, Mei L, Gao TM, Li JM. | 07/25/2015 |
| Erbin is an ErbB2 regulator for breast tumor formation and progression | Role of Erbin in ErbB2-dependent breast tumor growth.
Tao Y, Shen C, Luo S, Traoré W, Marchetto S, Santoni MJ, Xu L, Wu B, Shi C, Mei J, Bates R, Liu X, Zhao K, Xiong WC, Borg JP, Mei L., Free PMC Article | 04/25/2015 |
| analysis of the C-terminal ligand specificity of the erbin PDZ domain | Alteration of the C-terminal ligand specificity of the erbin PDZ domain by allosteric mutational effects.
Murciano-Calles J, McLaughlin ME, Erijman A, Hooda Y, Chakravorty N, Martinez JC, Shifman JM, Sidhu SS. | 02/7/2015 |
| Data suggest that Erbin can interact with Sema4C, and co-expression of Erbin blocks the process of Sema4C-induced epithelial-mesenchymal transition. | Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells.
Zhou QD, Ning Y, Zeng R, Chen L, Kou P, Xu CO, Pei GC, Han M, Xu G. | 11/8/2014 |
| Data reveal that Erbin is a negative regulator of AKT activation and suggest that Erbin may play a role in breast cancer progression. | Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance.
Liu D, Shi M, Duan C, Chen H, Hu Y, Yang Z, Duan H, Guo N. | 08/31/2013 |
| DSG1 and Erbin cooperate to repress MAPK signaling and promote keratinocyte differentiation. | Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation.
Harmon RM, Simpson CL, Johnson JL, Koetsier JL, Dubash AD, Najor NA, Sarig O, Sprecher E, Green KJ., Free PMC Article | 05/25/2013 |
| These results unravel a critical role of c-Myb in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression. | c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin.
Liu D, Shi M, Zhang H, Qian L, Yu M, Hu M, Zhang R, Wang T, Han C, Duan H, Guo N., Free PMC Article | 01/12/2013 |
| Data conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2beta regulates motility of cancer cells and suggest that LAP2beta may have utility for diagnostics and therapeutics in digestive tract cancers. | LAP2 is widely overexpressed in diverse digestive tract cancers and regulates motility of cancer cells.
Kim HJ, Hwang SH, Han ME, Baek S, Sim HE, Yoon S, Baek SY, Kim BS, Kim JH, Kim SY, Oh SO., Free PMC Article | 12/8/2012 |
| ERBIN binds to SARA using a domain (amino acids 1208-1265) that also interacts with SMAD2 and SMAD3, which we have called the SSID (SARA- and SMAD-interacting domain) | ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN.
Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C. | 01/14/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| This review discusses all-intracellular and membrane-associated localization of Densin-180 and its signaling, including a phosphorylation-rich area. | Densin-180: revised membrane topology, domain structure and phosphorylation status.
Thalhammer A, Trinidad JC, Burlingame AL, Schoepfer R., Free PMC Article | 01/21/2010 |
| Arginine 279, glutamic acid 246 in Smad3 and glutamic acid 1321 in Erbin are important for these proteins binding. | Biochemical studies and molecular dynamics simulations of Smad3-Erbin interaction identify a non-classical Erbin PDZ binding.
Déliot N, Chavent M, Nourry C, Lécine P, Arnaud C, Hermant A, Maigret B, Borg JP. | 01/21/2010 |
| erbin acts as a negative regulator of beta-catenin/T-cell-factor-dependent gene expression. An erbin mutant with a deletion of the N-terminal leucine-rich repeat allows the PDZ domain of erbin to increase beta-catenin/T-cell-factor-dependent transcription | The PDZ protein erbin modulates beta-catenin-dependent transcription.
Ress A, Moelling K. | 01/21/2010 |