| Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4. | Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
Kurano M, Uranbileg B, Yatomi Y. | 09/22/2023 |
| Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy. | Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy.
Kurano M, Tsukamoto K, Shimizu T, Hara M, Yatomi Y. | 06/26/2023 |
| Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway. | Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway.
Izquierdo MC, Shanmugarajah N, Lee SX, Kraakman MJ, Westerterp M, Kitamoto T, Harris M, Cook JR, Gusarova GA, Zhong K, Marbuary E, O-Sullivan I, Rasmus N, Camastra S, Unterman TG, Ferrannini E, Hurwitz BE, Haeusler RA., Free PMC Article | 04/9/2022 |
| Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages. | Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages.
Yao S, Zheng F, Yu Y, Zhan Y, Xu N, Luo G, Zheng L., Free PMC Article | 02/19/2022 |
| Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein. | Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Velagapudi S, Rohrer L, Poti F, Feuerborn R, Perisa D, Wang D, Panteloglou G, Potapenko A, Yalcinkaya M, Hülsmeier AJ, Hesse B, Lukasz A, Liu M, Parks JS, Christoffersen C, Stoffel M, Simoni M, Nofer JR, von Eckardstein A., Free PMC Article | 11/27/2021 |
| Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate. | Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate.
Del Gaudio I, Rubinelli L, Sasset L, Wadsack C, Hla T, Di Lorenzo A., Free PMC Article | 10/30/2021 |
| Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation. | Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
Shi Y, Lam SM, Liu H, Luo G, Zhang J, Yao S, Li J, Zheng L, Xu N, Zhang X, Shui G. | 07/10/2021 |
| Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharideinduced acute inflammatory apoM/ mice. | Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice.
Shi Y, Liu H, Liu H, Yu Y, Zhang J, Li Y, Luo G, Zhang X, Xu N., Free PMC Article | 05/1/2021 |
| Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway. | Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway.
Yao S, Zhang J, Zhan Y, Shi Y, Yu Y, Zheng L, Xu N, Luo G., Free PMC Article | 04/3/2021 |
| Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. | Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.
Ding BS, Yang D, Swendeman SL, Christoffersen C, Nielsen LB, Friedman SL, Powell CA, Hla T, Cao Z., Free PMC Article | 01/2/2021 |
| ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice | Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.
Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T., Free PMC Article | 07/11/2020 |
| Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis. | Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis.
Mathiesen Janiurek M, Soylu-Kucharz R, Christoffersen C, Kucharz K, Lauritzen M., Free PMC Article | 05/16/2020 |
| niacin treatment resulted in increased ApoM gene and protein expression levels in mice. In conclusion, niacin upregulates ApoM expression by increasing LXRalpha expression in vivo and in vitro. | Niacin regulates apolipoprotein M expression via liver X receptor‑α.
Yang L, Li T, Zhao S, Zhang S., Free PMC Article | 02/8/2020 |
| this study shows that apolipoprotein M protects lipopolysaccharide-treated mice from death and organ injury | Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.
Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y. | 10/5/2019 |
| ApoM displayed inhibitory effects against the inflammatory response in vivo and in vitro; these effects may be induced via the S1PR1 and DHCR24 pathways. | Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways.
Wang M, Luo GH, Liu H, Zhang YP, Wang B, Di DM, Zhan XH, Yu Y, Yao S, Zhang XY, Xu N. | 06/1/2019 |
| These results suggested that PPARgamma regulates the S1P levels by modulating apoM in a bell-shaped manner, with the greatest levels of apoM/S1P observed when PPARgamma was mildly expressed and that hepatic apoM/PPARgamma axis might maintain the homeostasis of S1P metabolism. | Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity.
Kurano M, Ikeda H, Iso-O N, Hara M, Tsukamoto K, Yatomi Y. | 04/6/2019 |
| the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism. | The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.
Christoffersen C, Federspiel CK, Borup A, Christensen PM, Madsen AN, Heine M, Nielsen CH, Kjaer A, Holst B, Heeren J, Nielsen LB. | 03/30/2019 |
| Results suggested that SR-BI deficiency promoted ApoM expression, but the increased ApoM might be independent from high density lipoprotein-mediated cholesterol uptake in hepatocytes. | Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes.
Feng YH, Zheng L, Wei J, Yu MM, Zhang J, Luo GH, Xu N., Free PMC Article | 11/17/2018 |
| apoM-S1P-S1PR1 signaling might underlie the pathogenesis of ALI and apoM could have physiological benefits to alleviate LPS-induced ALI. | Apolipoprotein M Protects Against Lipopolysaccharide-Induced Acute Lung Injury via Sphingosine-1-Phosphate Signaling.
Zhu B, Luo GH, Feng YH, Yu MM, Zhang J, Wei J, Yang C, Xu N, Zhang XY. | 10/6/2018 |
| These S1P-induced enhancements in growth factors and chemotactic cytokines in retinal pigment epithelium cells were significantly inhibited by ApoM treatment. Additionally, in vivo experiments using a laser-induced choroidal neovascularization (CNV) murine model demonstrated that intravitreal ApoM injection significantly reduced the progression of CNV formation. | Apolipoprotein M Inhibits Angiogenic and Inflammatory Response by Sphingosine 1-Phosphate on Retinal Pigment Epithelium Cells.
Terao R, Honjo M, Aihara M., Free PMC Article | 08/4/2018 |
| This study highlights the complexity of Apom/S1P in atherosclerosis and challenges the notion that the Apom/S1P complex is anti-atherogenic, at least in Apoe-deficient mice. | Effects of apolipoprotein M in uremic atherosclerosis.
Bosteen MH, Madsen Svarrer EM, Bisgaard LS, Martinussen T, Madsen M, Nielsen LB, Christoffersen C, Pedersen TX. | 06/9/2018 |
| This suggests that the autophagy dysfunction caused by the deficiency of ApoM is an important factor in hepatic steatosis (triglyceride accumulation). ApoM plays a key role in normal autophagy activity in the liver and thereby further regulates the metabolism of liver lipids, particularly triglycerides. | Autophagy dysregulation caused by ApoM deficiency plays an important role in liver lipid metabolic disorder.
Zhang X, Zhang P, Gao J, Huang Q. | 02/24/2018 |
| HDL facilitates S1P efflux from erythrocytes by both apoM-dependent and apoM-independent mechanisms. Moreover, apoM facilitates tubular reabsorption of S1P from the urine, however, with no impact on S1P plasma concentrations. | Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate.
Sutter I, Park R, Othman A, Rohrer L, Hornemann T, Stoffel M, Devuyst O, von Eckardstein A., Free PMC Article | 01/13/2018 |
| The study suggests that vascular leakage of albumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacerbates the response to inflammatory stimuli. | Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C., Free PMC Article | 08/19/2017 |
| apoM might facilitate the maintenance of CD4(+) T-lymphocytes or could modify the T-lymphocytes subgroups in murine spleen | Decreased Splenic CD4(+) T-Lymphocytes in Apolipoprotein M Gene Deficient Mice.
Wang Z, Luo G, Feng Y, Zheng L, Liu H, Liang Y, Liu Z, Shao P, Berggren-Söderlund M, Zhang X, Xu N., Free PMC Article | 10/1/2016 |