| The circ_0003928/miR-31-5p/MAPK6 cascade affects high glucose-induced inflammatory response, fibrosis and oxidative stress in HK-2 cells. | The circ_0003928/miR-31-5p/MAPK6 cascade affects high glucose-induced inflammatory response, fibrosis and oxidative stress in HK-2 cells.
Bao Z, Yu X, Zhang L. | 11/1/2024 |
| Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma. | Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma.
Zhang W, Liu T, Li X, Li T, Ma X, Zhao D, Zhao X., Free PMC Article | 05/30/2023 |
| ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization. | ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization.
Bogucka-Janczi K, Harms G, Coissieux MM, Bentires-Alj M, Thiede B, Rajalingam K., Free PMC Article | 05/19/2023 |
| miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes. | miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes.
Pang Y, Luo D, Wang S., Free PMC Article | 11/5/2022 |
| LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway. | LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.
Zhu H, Liu Q, Yang X, Ding C, Wang Q, Xiong Y. | 09/3/2022 |
| ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis. | ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis.
Bogucka K, Marini F, Rosigkeit S, Schloeder J, Jonuleit H, David K, Schlackow M, Rajalingam K. | 02/5/2022 |
| CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6. | CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6.
Yu XP, Liu CG, Qiu F, Xu YQ, Xing F, Yin JQ, Han SJ, Yu H, Han Y, Jing X, He GJ. | 07/3/2021 |
| ERK3 is transcriptionally upregulated by Np63alpha and mediates the role of Np63alpha in suppressing cell migration in non-melanoma skin cancers. | ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in non-melanoma skin cancers.
Alshammari ES, Aljagthmi AA, Stacy AJ, Bottomley M, Shamma HN, Kadakia MP, Long W., Free PMC Article | 05/15/2021 |
| miR6535p suppresses the growth and migration of breast cancer cells by targeting MAPK6. | miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6.
Zhang M, Wang H, Zhang X, Liu F., Free PMC Article | 05/8/2021 |
| let7f5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6. | let7f‑5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6.
Xu L, Song Q, Ouyang Z, Zhang X, Zhang C., Free PMC Article | 05/8/2021 |
| ERK3/MAPK6 controls IL-8 production and chemotaxis. | ERK3/MAPK6 controls IL-8 production and chemotaxis.
Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K., Free PMC Article | 04/3/2021 |
| Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3. | Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.
Schröder M, Filippakopoulos P, Schwalm MP, Ferrer CA, Drewry DH, Knapp S, Chaikuad A., Free PMC Article | 03/6/2021 |
| NEAT1/hsa-mir-98-5p/MAPK6 is involved in the development and progress in non-small-cell lung cancer. | NEAT1/hsa-mir-98-5p/MAPK6 axis is involved in non-small-cell lung cancer development.
Wu F, Mo Q, Wan X, Dan J, Hu H. | 06/20/2020 |
| MiR-144-3p: a novel tumor suppressor targeting MAPK6 in cervical cancer. | MiR-144-3p: a novel tumor suppressor targeting MAPK6 in cervical cancer.
Wu J, Zhao Y, Li F, Qiao B. | 12/21/2019 |
| MicroRNA-138 knockdown promotes proliferation and inhibits apoptosis of laryngeal carcinoma cells via inhibiting MAPK6 expression. | MicroRNA-138 inhibits proliferation and induces apoptosis of laryngeal carcinoma via targeting MAPK6.
Zhou YH, Huang YY, Ma M. | 11/16/2019 |
| Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. ERK3 is a newfound potential prognostic predictor and a tumor suppressor in ICC. | Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1.
Ling S, Xie H, Yang F, Shan Q, Dai H, Zhuo J, Wei X, Song P, Zhou L, Xu X, Zheng S., Free PMC Article | 12/9/2017 |
| Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. | ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.
Bian K, Muppani NR, Elkhadragy L, Wang W, Zhang C, Chen T, Jung S, Seternes OM, Long W., Free PMC Article | 01/28/2017 |
| MAPK6 could rescue the cell growth induced by miR499a and HBV | Up-regulated microRNA499a by hepatitis B virus induced hepatocellular carcinogenesis via targeting MAPK6.
Xiang Z, Wang S, Xiang Y., Free PMC Article | 01/16/2016 |
| ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. | ERK3 promotes endothelial cell functions by upregulating SRC-3/SP1-mediated VEGFR2 expression.
Wang W, Bian K, Vallabhaneni S, Zhang B, Wu RC, O'Malley BW, Long W., Free PMC Article | 09/6/2014 |
| These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation. | Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3.
Sun M, Wei Y, Yao L, Xie J, Chen X, Wang H, Jiang J, Gu J. | 05/16/2014 |
| Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. | A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3.
Hansen CA, Bartek J, Jensen S. | 05/16/2014 |
| identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling. | Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity.
De la Mota-Peynado A, Chernoff J, Beeser A., Free PMC Article | 05/16/2014 |
| A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation. | ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
Long W, Foulds CE, Qin J, Liu J, Ding C, Lonard DM, Solis LM, Wistuba II, Qin J, Tsai SY, Tsai MJ, O'Malley BW., Free PMC Article | 05/16/2014 |
| Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues. | N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.
Coulombe P, Rodier G, Bonneil E, Thibault P, Meloche S., Free PMC Article | 01/21/2010 |
| ERK3 biological activity is regulated by its cellular abundance through the control of protein stability | Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche S., Free PMC Article | 01/21/2010 |