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    MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens (human) ]

    Gene ID: 5599, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.

    Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
    Zeng Q, Zhang S, He L, Fu Q, Liao L, Chen L, Ding X.

    04/17/2024
    DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy.

    DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy.
    Liu X, Ye Z, Rao D, Chen Q, Zhang Z.

    03/7/2024
    Leukocyte Ig-like receptor A3 facilitates inflammation, migration and invasion of synovial tissue-derived fibroblasts via ERK/JNK activation.

    Leukocyte Ig-like receptor A3 facilitates inflammation, migration and invasion of synovial tissue-derived fibroblasts via ERK/JNK activation.
    Liu M, Tang Y, Du Y, Zhang J, Hu F, Zou Y, Li Y, Zhu L, He J, Guo J, Li Z.

    03/5/2024
    Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells.

    Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells.
    Louw-du Toit R, Simons M, Africander D.

    02/5/2024
    JNK promotes the progression of castration-resistant prostate cancer.

    JNK promotes the progression of castration-resistant prostate cancer.
    Feng Y, Cao H, Wang D, Chen L, Gao R, Sun P.

    12/27/2023
    HPV16 E7 protein antagonizes TNF-alpha-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.

    HPV16 E7 protein antagonizes TNF-α-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.
    Ding S, Wang H, Liao Y, Chen R, Hu Y, Wu H, Shen H, Tang S.

    12/6/2023
    H3K27 acetylation activated-CD109 evokes 5-fluorouracil resistance in gastric cancer via the JNK/MAPK signaling pathway.

    H3K27 acetylation activated-CD109 evokes 5-fluorouracil resistance in gastric cancer via the JNK/MAPK signaling pathway.
    Zhou F, Wang L, Ge H, Zhang D, Wang W.

    11/22/2023
    MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis.

    MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis.
    Chai F, Peng H, Qin L, Liu C, Zeng Y, Wang R, Xu G, Wang R, Wei G, Huang H, Lan Y, Chen W, Wang C.

    11/21/2023
    JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1.

    JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1.
    Tabanifar B, Moorthy A, Tsai HH, Kannan S, Verma CS, Sabapathy K.

    10/11/2023
    N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye.

    N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.
    Deshpande P, Chimata AV, Snider E, Singh A, Kango-Singh M, Singh A., Free PMC Article

    08/14/2023
    Phosphorylation of Bcl-2 by JNK confers gemcitabine resistance in lung cancer cells by reducing autophagy-mediated cell death.

    Phosphorylation of Bcl-2 by JNK confers gemcitabine resistance in lung cancer cells by reducing autophagy-mediated cell death.
    Chiu CH, Ramesh S, Liao PH, Kuo WW, Chen MC, Kuo CH, Li CC, Wang TF, Lin YM, Lin YJ, Huang CY.

    08/10/2023
    Osmotic pressure induces translocation of aquaporin-8 by P38 and JNK MAPK signaling pathways in patients with functional constipation.

    Osmotic pressure induces translocation of aquaporin-8 by P38 and JNK MAPK signaling pathways in patients with functional constipation.
    Lin C, He H, Kim JJ, Zheng X, Huang Z, Dai N.

    07/31/2023
    Human gammadelta T cells induce CD8[+] T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK.

    Human γδ T cells induce CD8(+) T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK.
    Wang S, Li H, Chen T, Zhou H, Zhang W, Lin N, Yu X, Lou Y, Li B, Yinwang E, Wang Z, Wang K, Xue Y, Qu H, Lin P, Sun H, Teng W, Mou H, Chai X, Cai Z, Ye Z., Free PMC Article

    05/31/2023
    JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.

    JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
    Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, Zhang X, Guo F.

    05/23/2023
    c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD.

    c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD.
    Sahana TG, Chase KJ, Liu F, Lloyd TE, Rossoll W, Zhang K., Free PMC Article

    05/17/2023
    Glyceraldehyde-3-phosphate dehydrogenase regulates activation of c-Jun N-terminal kinase under oxidative stress.

    Glyceraldehyde-3-phosphate dehydrogenase regulates activation of c-Jun N-terminal kinase under oxidative stress.
    Itakura M, Kubo T, Kaneshige A, Nakajima H.

    04/14/2023
    c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis.

    c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis.
    Yang J, Wang J, Zhang Y, Huang W, Zhang S, Yin P, Tan W.

    02/22/2023
    Silencing of UCA1 attenuates the ox-LDL-induced injury of human umbilical vein endothelial cells via miR-873-5p/MAPK8 axis.

    Silencing of UCA1 attenuates the ox-LDL-induced injury of human umbilical vein endothelial cells via miR-873-5p/MAPK8 axis.
    Zhang SX, Yu CH.

    02/11/2023
    USP14 promotes colorectal cancer progression by targeting JNK for stabilization.

    USP14 promotes colorectal cancer progression by targeting JNK for stabilization.
    Du XH, Ke SB, Liang XY, Gao J, Xie XX, Qi LZ, Liu XY, Xu GY, Zhang XD, Du RL, Li SZ., Free PMC Article

    02/4/2023
    Highly expressed FYN promotes the progression of placenta accreta by activating STAT3, p38, and JNK signaling pathways.

    Highly expressed FYN promotes the progression of placenta accreta by activating STAT3, p38, and JNK signaling pathways.
    Liu M, Su C, Zhu L, Dong F, Shu H, Zhang H, Wang M, Wang F, Man D.

    02/4/2023
    JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA.

    JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA.
    Ni Z, Sun P, Zheng J, Wu M, Yang C, Cheng M, Yin M, Cui C, Wang G, Yuan L, Gao Q, Li Y.

    05/14/2022
    c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1.

    c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1.
    Tian X, Traub B, Shi J, Huber N, Schreiner S, Chen G, Zhou S, Henne-Bruns D, Knippschild U, Kornmann M., Free PMC Article

    04/9/2022
    c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.

    c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.
    Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ., Free PMC Article

    02/19/2022
    Pin1 and JNK1 cooperatively modulate TAp63gamma.

    Pin1 and JNK1 cooperatively modulate TAp63γ.
    Fan X, He W, Hu K, Chen H, Chen L, Fan S, Li C., Free PMC Article

    01/1/2022
    Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK).

    Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK).
    Bressler KR, Ross JA, Ilnytskyy S, Vanden Dungen K, Taylor K, Patel K, Zovoilis A, Kovalchuk I, Thakor N., Free PMC Article

    12/25/2021
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