| SARS-CoV-2 hijacks p38beta/MAPK11 to promote virus replication. | SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication.
Higgins CA, Nilsson-Payant BE, Bonaventure B, Kurland AP, Ye C, Yaron TM, Johnson JL, Adhikary P, Golynker I, Panis M, Danziger O, Rosenberg BR, Cantley LC, Martínez-Sobrido L, tenOever B, Johnson JR., Free PMC Article | 09/6/2023 |
| p38beta - MAPK11 and its role in female cancers. | p38β - MAPK11 and its role in female cancers.
Katopodis P, Kerslake R, Zikopoulos A, Beri N, Anikin V., Free PMC Article | 01/15/2022 |
| Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling pathways with endocytic recycling. | Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling pathways with endocytic recycling.
Mao L, Liao C, Qin J, Gong Y, Zhou Y, Li S, Liu Z, Deng H, Deng W, Sun Q, Mo X, Xue Y, Billadeau DD, Dai L, Li G, Jia D., Free PMC Article | 09/25/2021 |
| Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway. | Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway.
Coates MS, Alton EWFW, Rapeport GW, Davies JC, Ito K., Free PMC Article | 07/24/2021 |
| p38beta (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models. | p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models.
Pascual-Serra R, Fernández-Aroca DM, Sabater S, Roche O, Andrés I, Ortega-Muelas M, Arconada-Luque E, Garcia-Flores N, Bossi G, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R. | 05/1/2021 |
| HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner. | HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.
Zhao Q, Li C, Yu M, Sun Y, Wang J, Ma L, Sun X, Lu B., Free PMC Article | 05/1/2021 |
| Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11. | Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11.
Yao Z, Xu R, Yuan L, Xu M, Zhuang H, Li Y, Zhang Y, Lin N., Free PMC Article | 09/12/2020 |
| Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11. | Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11.
Li Y, Kong C, Wu C, Wang Y, Xu B, Liang S, Ying X., Free PMC Article | 09/12/2020 |
| the present results suggested that p38a knockdown impaired migration and proliferation, and increased senescence, in A375 melanoma cells. However, p38b may not be involved in melanoma tumorigenesis. | Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.
Wen SY, Cheng SY, Ng SC, Aneja R, Chen CJ, Huang CY, Kuo WW., Free PMC Article | 04/18/2020 |
| The two kinases HIPK3 and MAPK11 effect on Huntingtin (HTT)levels are mutant HTT protein (mHTT)-dependent, providing a feedback mechanism in which mHTT enhances its own level thus contributing to mHTT accumulation and disease progression. | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.
Yu M, Fu Y, Liang Y, Song H, Yao Y, Wu P, Yao Y, Pan Y, Wen X, Ma L, Hexige S, Ding Y, Luo S, Lu B., Free PMC Article | 08/18/2018 |
| Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity. | p38β Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261.
Beenstock J, Melamed D, Mooshayef N, Mordechay D, Garfinkel BP, Ahn NG, Admon A, Engelberg D., Free PMC Article | 05/27/2017 |
| p38beta was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. p38beta expression was observed to be significantly associated with overall prognosis. | Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma.
Zheng S, Yang C, Liu T, Liu Q, Dai F, Sheyhidin I, Lu X. | 02/18/2017 |
| Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling. | R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.
Sawada J, Li F, Komatsu M., Free PMC Article | 08/20/2016 |
| These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation. | Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation.
Kim GY, Kim H, Lim HJ, Park HY. | 04/2/2016 |
| The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder. | Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins.
Córdova-Palomera A, Fatjó-Vilas M, Gastó C, Navarro V, Krebs MO, Fañanás L., Free PMC Article | 01/16/2016 |
| p38beta is a novel regulatory target of the transcription factor Pokemon and positively regulated by Pokemon in hepatic cells. | p38β, A novel regulatory target of Pokemon in hepatic cells.
Chen Z, Liu F, Zhang N, Cao D, Liu M, Tan Y, Jiang Y., Free PMC Article | 10/3/2015 |
| Data show that the p38 MAPK (p38) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell. | MAPK11 in breast cancer cells enhances osteoclastogenesis and bone resorption.
He Z, He J, Liu Z, Xu J, Yi SF, Liu H, Yang J., Free PMC Article | 08/1/2015 |
| Differential roles for p38alpha and p38beta in the HGF-induced expression of key osteogenic markers. | Hepatocyte growth factor and p38 promote osteogenic differentiation of human mesenchymal stem cells.
Aenlle KK, Curtis KM, Roos BA, Howard GA., Free PMC Article | 12/20/2014 |
| study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells | The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.
Beenstock J, Ben-Yehuda S, Melamed D, Admon A, Livnah O, Ahn NG, Engelberg D., Free PMC Article | 12/20/2014 |
| Study identifies Hsp27 as a novel target of ILK-p38beta signaling complexes, playing a key role in bladder cancer cell migration. | Selective regulation of p38β protein and signaling by integrin-linked kinase mediates bladder cancer cell migration.
Yu L, Yuan X, Wang D, Barakat B, Williams ED, Hannigan GE. | 06/28/2014 |
| inhibition of the SOCE downstream target CaM kinase kinase beta (CaMKKbeta) or knockdown of AMPKalpha1 suppressed PAR-1-mediated phosphorylation of p38beta and hence STIM1. | Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38β mitogen-activated protein kinase.
Sundivakkam PC, Natarajan V, Malik AB, Tiruppathi C., Free PMC Article | 08/31/2013 |
| Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling | TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.
Ferrari G, Terushkin V, Wolff MJ, Zhang X, Valacca C, Poggio P, Pintucci G, Mignatti P., Free PMC Article | 11/24/2012 |
| Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells. | Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.
Kogai T, Liu YY, Mody K, Shamsian DV, Brent GA., Free PMC Article | 03/24/2012 |
| results demonstrate that IFN-alpha can regulate growth inhibition of Jurkat cells through p38alpha and p38beta | Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta.
Lee WH, Liu FH, Lee YL, Huang HM. | 10/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |