| KIS counteracts PTBP2 and regulates alternative exon usage in neurons. | KIS counteracts PTBP2 and regulates alternative exon usage in neurons.
Moreno-Aguilera M, Neher AM, Mendoza MB, Dodel M, Mardakheh FK, Ortiz R, Gallego C., Free PMC Article | 05/8/2024 |
| hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells. | hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
Feng S, Li J, Wen H, Liu K, Gui Y, Wen Y, Wang X, Yuan S., Free PMC Article | 07/2/2022 |
| Axonogenesis-associated splicing changes are governed by PTBP2. | Axonogenesis Is Coordinated by Neuron-Specific Alternative Splicing Programming and Splicing Regulator PTBP2.
Zhang M, Ergin V, Lin L, Stork C, Chen L, Zheng S., Free PMC Article | 08/31/2019 |
| splicing regulation by Ptbp2 is critical for germ cell communication with Sertoli cells | Ptbp2 Controls an Alternative Splicing Network Required for Cell Communication during Spermatogenesis.
Hannigan MM, Zagore LL, Licatalosi DD., Free PMC Article | 03/31/2018 |
| In round spermatids, MRG15 colocalizes with splicing factors PTBP1 and PTBP2 at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2). Thus, our results reveal that MRG15 is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder | MRG15 is required for pre-mRNA splicing and spermatogenesis.
Iwamori N, Tominaga K, Sato T, Riehle K, Iwamori T, Ohkawa Y, Coarfa C, Ono E, Matzuk MM., Free PMC Article | 01/27/2018 |
| This knockin Ptbp1 rescued a forebrain-specific, but not a pan-neuronal, Ptbp2 knockout, demonstrating both redundant and distinct roles for the proteins. Many developmentally regulated exons exhibited different sensitivities to PTBP1 and PTBP2. | PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing.
Vuong JK, Lin CH, Zhang M, Chen L, Black DL, Zheng S., Free PMC Article | 11/25/2017 |
| Ptbp2 is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia. | Association between RNA-binding protein Ptbp2 and germ cell injury in an experimentally-induced unilateral cryptorchidism murine model.
Dou X, Gao J, Gao P, Tang D, Peng D, Mao J, Huang Z, Chen P, Chen H, Ke S, Liang C, Zhang X., Free PMC Article | 11/4/2017 |
| Ptbp2 ablation results in germ cell loss due to increased apoptosis of meiotic spermatocytes and postmeiotic arrest of spermatid differentiation. | RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development.
Zagore LL, Grabinski SE, Sweet TJ, Hannigan MM, Sramkoski RM, Li Q, Licatalosi DD., Free PMC Article | 02/20/2016 |
| These results define a new genetic regulatory program, where PTBP2 acts to temporarily repress expression of adult protein isoforms until the final maturation of the neuron. | The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.
Li Q, Zheng S, Han A, Lin CH, Stoilov P, Fu XD, Black DL., Free PMC Article | 02/13/2016 |
| Thus, Ptbp2 inhibition of a discrete set of adult neuronal exons underlies early brain development prior to neuronal differentiation and is essential for postnatal survival. | Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB., Free PMC Article | 09/29/2012 |
| The expression of PSD-95 during early neural development is controlled at the RNA level by two PTB proteins whose sequential downregulation is necessary for synapse maturation. | PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
Zheng S, Gray EE, Chawla G, Porse BT, O'Dell TJ, Black DL., Free PMC Article | 04/21/2012 |
| The present study provides evidence that alternative neuronal nPTB and Fox-1/Fox-2 isoforms are also produced in lenses | Evidence that "brain-specific" FOX-1, FOX-2, and nPTB alternatively spliced isoforms are produced in the lens.
Bitel CL, Nathan R, Wong P, Kuppasani S, Matsushita M, Kanazawa H, Frederikse PH. | 07/2/2011 |
| Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein. | Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein.
Tang ZZ, Sharma S, Zheng S, Chawla G, Nikolic J, Black DL., Free PMC Article | 06/18/2011 |
| Reduction of PTBP2 levels led to decreases in 7 of 10 of the mRNAs, to the repression of alternative splicing of introns, and to reductions in specific miRNAs. | Polypyrimidine tract-binding protein 2 binds to selective, intronic messenger RNA and microRNA targets in the mouse testis.
Xu M, Hecht NB. | 06/18/2011 |
| knock-down inhibits immunoglobulin class-switch recombination | The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA.
Nowak U, Matthews AJ, Zheng S, Chaudhuri J., Free PMC Article | 06/18/2011 |
| The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown. | HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.
Bitel CL, Perrone-Bizzozero NI, Frederikse PH., Free PMC Article | 02/26/2011 |
| PTBP2 was identified as a brain-expressed protein that interacts with the paraneoplastic target antigen Nova1 by yeast 2-hybrid, in vivo co-IP and co-localization in neurons. Functionally, the proteins antagonize each other in splicing assays. | A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.
Polydorides AD, Okano HJ, Yang YY, Stefani G, Darnell RB., Free PMC Article | 12/23/2009 |
| PTBP2 is a trans-acting factor that helps to stabilize Pgk2 mRNA in male mouse germ cells. | Polypyrimidine tract binding protein 2 stabilizes phosphoglycerate kinase 2 mRNA in murine male germ cells by binding to its 3'UTR.
Xu M, Hecht NB. | 01/21/2010 |
| The post-transcriptional switch from PTB to nPTB controls a widespread alternative splicing program during neuronal development. | A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons.
Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, Ostrow K, Shiue L, Ares M Jr, Black DL., Free PMC Article | 01/21/2010 |