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    SUSD2 sushi domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 56241, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The dual role of SUSD2 in cancer development.

    The dual role of SUSD2 in cancer development.
    Bai H, Xian N, Zhao F, Zhou Y, Qin S.

    07/8/2024
    CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2.

    CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2.
    Wu Y, Duan Y, Li X, Zhao R, Lan B, Zhang X, Wang X, Chen H, Feng S, Liu Z, Cheng Y, Xi L, Wang Y, Xue F, Xuan C.

    11/12/2022
    miR-141-3p promotes retinoblastoma progression via inhibiting sushi domain-containing protein 2.

    miR-141-3p promotes retinoblastoma progression via inhibiting sushi domain-containing protein 2.
    Liu S, Wen C., Free PMC Article

    04/23/2022
    Genetic variants in SUSD2 are associated with the risk of ischemic heart disease.

    Genetic variants in SUSD2 are associated with the risk of ischemic heart disease.
    Bruikman CS, Dalila N, van Capelleveen JC, Kroon J, Peter J, Havik SR, Willems M, Huisman LC, de Boer OJ, Hovingh GK, Tybjaerg-Hansen A, Dallinga-Thie GM.

    08/7/2021
    LncRNA small nucleolar RNA host gene 16 (SNHG16) silencing protects lipopolysaccharide (LPS)-induced cell injury in human lung fibroblasts WI-38 through acting as miR-141-3p sponge.

    LncRNA small nucleolar RNA host gene 16 (SNHG16) silencing protects lipopolysaccharide (LPS)-induced cell injury in human lung fibroblasts WI-38 through acting as miR-141-3p sponge.
    Xia L, Zhu G, Huang H, He Y, Liu X.

    08/7/2021
    Cultured cardiac fibroblasts and myofibroblasts express Sushi Containing Domain 2 and assemble a unique fibronectin rich matrix.

    Cultured cardiac fibroblasts and myofibroblasts express Sushi Containing Domain 2 and assemble a unique fibronectin rich matrix.
    Schmuck EG, Roy S, Dhillon A, Walker S, Spinali K, Colevas S, Zhou T, Chhabra G, Liu Y, Kader Sagar MA, Childs CJ, Kink JA, Eliceiri KW, Hematti P, Raval AN.

    06/12/2021
    CircTOP2A acts as a ceRNA for miR346 and contributes to glioma progression via the modulation of sushi domaincontaining 2.

    Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2.
    Sang J, Li X, Lv L, Zhang C, Zhang X, Li G., Free PMC Article

    05/8/2021
    TPM4 aggravates the malignant progression of hepatocellular carcinoma through negatively regulating SUSD2.

    TPM4 aggravates the malignant progression of hepatocellular carcinoma through negatively regulating SUSD2.
    Sheng ZG, Chen MH.

    04/24/2021
    SUSD2 was identified as a candidate biomarker for hepatic recurrences of gastric cancer by transcriptome analysis. Patients with high SUSD2 expression were more likely to experience shorter disease-free and overall survival. Also, SUSD2 may reflect the malignant potential of gastric cancer and predict hepatic recurrences after curative resection.

    Expression of sushi domain containing two reflects the malignant potential of gastric cancer.
    Umeda S, Kanda M, Miwa T, Tanaka H, Tanaka C, Kobayashi D, Suenaga M, Hattori N, Hayashi M, Yamada S, Nakayama G, Fujiwara M, Kodera Y., Free PMC Article

    12/21/2019
    platelet activation and binding to high-grade serous ovarian carcinoma cells was inversely correlated with the presence of SUSD2. This represents one of the first tumor proteins known to provide differential platelet interaction based on protein status.

    Sushi Domain Containing 2 (SUSD2) inhibits platelet activation and binding to high-grade serous ovarian carcinoma cells.
    Lager TW, Roetman JJ, Kunkel J, Thacker M, Sheets JN, Egland KA, Miles CM, Larson MK, Gubbels JAA.

    12/22/2018
    suggest that SUSD2 counteracts senescence and cell death and is thus a potential chemotherapeutic target in human endometrial cancer

    Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells.
    Zhang S, Zeng N, Alowayed N, Singh Y, Cheng A, Lang F, Salker MS., Free PMC Article

    10/28/2017
    Tumors with high levels of SUSD2 staining contained 2-fold more tumor-associated macrophages, mainly of the M2 pro-angiogenic phenotype

    SUSD2 promotes tumor-associated macrophage recruitment by increasing levels of MCP-1 in breast cancer.
    Hultgren EM, Patrick ME, Evans RL, Stoos CT, Egland KA., Free PMC Article

    09/16/2017
    Low SUSD2 expression is associated with renal cell carcinoma and lung cancer.

    SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer.
    Cheng Y, Wang X, Wang P, Li T, Hu F, Liu Q, Yang F, Wang J, Xu T, Han W.

    03/4/2017
    No evidence of association between polymorphisms in SUSD2 and sporadic amyotrophic lateral sclerosis in Han Chinese

    No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese.
    An R, Xi J, Yang X, Yao X, Xu Y.

    02/13/2016
    Authors found significantly fewer CD4 tumor infiltrating lymphocytes in breast tumors expressing Susd2.

    Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis.
    Watson AP, Evans RL, Egland KA., Free PMC Article

    10/19/2013
    Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1.

    Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.
    Deng M, Wei L, Zuo X, Tian Y, Xie F, Hu P, Zhu C, Yu F, Meng Y, Wang H, Zhang F, Ma H, Ye R, Cheng H, Du J, Dong W, Zhou S, Wang C, Wang Y, Wang J, Chen X, Sun Z, Zhou N, Jiang Y, Liu X, Li X, Zhang N, Liu N, Guan Y, Han Y, Han Y, Lv X, Fu Y, Yu H, Xi C, Xie D, Zhao Q, Xie P, Wang X, Zhang Z, Shen L, Cui Y, Yin X, Cheng H, Liang B, Zheng X, Lee TM, Chen G, Zhou F, Veldink JH, Robberecht W, Landers JE, Andersen PM, Al-Chalabi A, Shaw C, Liu C, Tang B, Xiao S, Robertson J, Zhang F, van den Berg LH, Sun L, Liu J, Yang S, Ju X, Wang K, Zhang X.

    08/3/2013
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