| Here, the authors show that Shigella flexneri invasion plasmid antigen H (IpaH) 4.5, a member of the E3 ubiquitin ligase effector family, targets the proteasome regulatory particle non-ATPase 13 (RPN13) and induces its degradation via the ubiquitin-proteasome system (UPS). | Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
Otsubo R, Mimuro H, Ashida H, Hamazaki J, Murata S, Sasakawa C. | 05/16/2020 |
| ADRM1-dependent ubiquitin proteasome system (UPS) may be a general mechanism to guard cells from mutant Htt toxicity | The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.
Huang ZN, Her LS. | 05/11/2019 |
| studies suggest that HAP40-mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction. | Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.
Huang ZN, Chung HM, Fang SC, Her LS., Free PMC Article | 09/1/2018 |
| Data show that either Rpn13 knock down or RA190 treatment reduced the capacity of myeloid-derived-suppressor cells (MDSCs) to suppress T cell proliferation in vitro. | RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells.
Soong RS, Anchoori RK, Yang B, Yang A, Tseng SH, He L, Tsai YC, Roden RB, Hung CF., Free PMC Article | 02/17/2018 |
| the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation. | Binding of SGTA to Rpn13 selectively modulates protein quality control.
Leznicki P, Korac-Prlic J, Kliza K, Husnjak K, Nyathi Y, Dikic I, High S., Free PMC Article | 06/4/2016 |
| this study showed that Rpn13 plays a redundant role with Rpn10 in recognition and degradation of ubiquitinated proteins in mouse livers. | Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
Hamazaki J, Hirayama S, Murata S., Free PMC Article | 05/7/2016 |
| this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis | Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
Al-Shami A, Jhaver KG, Vogel P, Wilkins C, Humphries J, Davis JJ, Xu N, Potter DG, Gerhardt B, Mullinax R, Shirley CR, Anderson SJ, Oravecz T., Free PMC Article | 03/12/2011 |
| show that Rpn13 is involved in inducible nitric oxide synthase degradation and is required for iNOS interaction with the deubiquitination protein UCH37. | Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).
Mazumdar T, Gorgun FM, Sha Y, Tyryshkin A, Zeng S, Hartmann-Petersen R, Jørgensen JP, Hendil KB, Eissa NT., Free PMC Article | 09/13/2010 |
| crystallography and NMR data to describe the ubiquitin-binding mechanism of Rpn13 | Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M., Free PMC Article | 01/21/2010 |
| identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome | Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I., Free PMC Article | 01/21/2010 |
| ARM-1 is a cytosolic protein associated with the plasma membrane. However, no cell surface expression of the protein was observed. These results suggest an indirect role of ARM-1 in adhesion rather than a direct role as an adhesion molecule itself. | Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells.
Lamerant N, Kieda C. | 01/21/2010 |