| SUMOylation and coupling of eNOS mediated by PIAS1 contribute to maintenance of vascular homeostasis. | SUMOylation and coupling of eNOS mediated by PIAS1 contribute to maintenance of vascular homeostasis.
Wang L, Zeng W, Wang C, Lu Y, Xiong X, Chen S, Huang Q, Yan F, Huang Q. | 01/31/2024 |
| PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence. | PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence.
Wang G, Zhao Y, Zhou Y, Jiang L, Liang L, Kong F, Yan Y, Wang X, Wang Y, Wen X, Zeng X, Tian G, Deng G, Shi J, Liu L, Chen H, Li C., Free PMC Article | 05/7/2022 |
| SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-kappaB and Notch signaling. | SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling.
Robinson NJ, Miyagi M, Scarborough JA, Scott JG, Taylor DJ, Schiemann WP., Free PMC Article | 01/22/2022 |
| SUMO E3 ligase PIAS1 is a potential biomarker indicating stress susceptibility. | SUMO E3 ligase PIAS1 is a potential biomarker indicating stress susceptibility.
Lin HY, Liu YS, Huang CY, Cathomas F, Liu K, Wang J, Cheng HT, Lai SW, Liu YC, Chen CJ, Lin C, Lu DY. | 07/17/2021 |
| The present study raises the possibility of different levels of PIAS1 between individuals in response to chronic social defeat stress and that such differences may contribute to the susceptibility to stress. | Targeted Ubiquitin-Proteasomal Proteolysis Pathway in Chronic Social Defeat Stress.
Lin HY, Liu YS, Liu YC, Chen CJ, Lu DY. | 02/22/2020 |
| These findings demonstrate the crucial role of PIAS1-mediated PPARgamma SUMOylation in protecting against myocardial ischemia-reperfusion injury. | PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation.
Xie B, Liu X, Yang J, Cheng J, Gu J, Xue S., Free PMC Article | 06/1/2019 |
| these results indicate that PIAS1 is a positive regulator of MYC. | PIAS1 Promotes Lymphomagenesis through MYC Upregulation.
Rabellino A, Melegari M, Tompkins VS, Chen W, Van Ness BG, Teruya-Feldstein J, Conacci-Sorrell M, Janz S, Scaglioni PP., Free PMC Article | 09/23/2017 |
| PIAS1 overexpression exacerbated mutant Huntingtin-associated phenotypes and aberrant protein accumulation | PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.
Ochaba J, Monteys AM, O'Rourke JG, Reidling JC, Steffan JS, Davidson BL, Thompson LM., Free PMC Article | 08/26/2017 |
| Pias1 expression in primary myoblasts enhances the induction of cardiac muscle genes MyoD, Myogenin and Myomaker. Endothelial cell specific inactivation of Pias1 in vivo impairs yolk sac erythrogenesis, angiogenesis and recapitulates loss of myocardium muscle mass. Pias1 is an essential gene for YS erythropoiesis and vasculogenesis in vivo. | Pias1 is essential for erythroid and vascular development in the mouse embryo.
Constanzo JD, Deng M, Rindhe S, Tang KJ, Zhang CC, Scaglioni PP., Free PMC Article | 06/24/2017 |
| Data suggest overexpression of Pias1 in white adipose tissue (WAT) of obesity/prediabetes improves insulin resistance; knockdown of Pias1 in normal WAT leads to insulin resistance; Pias1 expression in WAT is down-regulated by c-Jun N-terminal kinase. | Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue.
Liu Y, Ge X, Dou X, Guo L, Liu Y, Zhou SR, Wei XB, Qian SW, Huang HY, Xu CJ, Jia WP, Dang YJ, Li X, Tang QQ. | 03/19/2016 |
| Between the E3 SUMO ligase PIAS1 and STAT-3. | PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic cells generated with IL-15.
Hanke NT, LaCasse CJ, Larmonier CB, Alizadeh D, Trad M, Janikashvili N, Bonnotte B, Katsanis E, Larmonier N., Free PMC Article | 11/22/2014 |
| Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 binding site is unable to increase STI1 nuclear retention. | Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1.
Soares IN, Caetano FA, Pinder J, Rodrigues BR, Beraldo FH, Ostapchenko VG, Durette C, Pereira GS, Lopes MH, Queiroz-Hazarbassanov N, Cunha IW, Sanematsu PI, Suzuki S, Bleggi-Torres LF, Schild-Poulter C, Thibault P, Dellaire G, Martins VR, Prado VF, Prado MA., Free PMC Article | 06/7/2014 |
| A novel role of PIAS1 in maintaining the quiescence of dormant hematopoietic stem cells and in the epigenetic repression of the myeloerythroid program. | PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells.
Liu B, Yee KM, Tahk S, Mackie R, Hsu C, Shuai K., Free PMC Article | 03/15/2014 |
| The present study showed that PIAS1 functions as a SUMO E3 ligase of C/EBPbeta to regulate adipogenesis. | Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein β (C/EBPβ) during adipogenesis.
Liu Y, Zhang YD, Guo L, Huang HY, Zhu H, Huang JX, Liu Y, Zhou SR, Dang YJ, Li X, Tang QQ., Free PMC Article | 12/28/2013 |
| Piasy represses the synergistic activation of PITX2 with interacting co-factors and Piasy represses Pias1 activation of PITX2 transcriptional activity. | Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.
Wang J, Sun Z, Zhang Z, Saadi I, Wang J, Li X, Gao S, Engle JJ, Kuburas A, Fu X, Yu W, Klein WH, Russo AF, Amendt BA., Free PMC Article | 07/13/2013 |
| MAPK-activated protein kinase-2 limits endothelial inflammation via the PIAS1 S522 phosphorylation-mediated increase in PIAS1 transrepression and SUMO ligase activity. | Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe J., Free PMC Article | 03/16/2013 |
| Results suggest that PIAS1 may serve as a lipogenic regulator by negatively modulating liver X receptors (LXRs) in a SUMOylation-independent manner. | A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.
Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y., Free PMC Article | 01/26/2013 |
| PIAS1 modifies covalent modification of Blimp-1 by SUMO-1 at lysine 816. | SUMOylation of Blimp-1 is critical for plasma cell differentiation.
Ying HY, Su ST, Hsu PH, Chang CC, Lin IY, Tseng YH, Tsai MD, Shih HM, Lin KI., Free PMC Article | 11/17/2012 |
| PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein independent of its SUMO ligase activity. | PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein independent of its SUMO ligase activity.
Song YJ, Lee H., Free PMC Article | 02/4/2012 |
| FOXL2 interacts with PIAS1 and UBC9, and sumoylated in both human and mouse | The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.
Marongiu M, Deiana M, Meloni A, Marcia L, Puddu A, Cao A, Schlessinger D, Crisponi L., Free PMC Article | 01/15/2011 |
| PIAS1 restricts the differentiation of natural T(reg) cells by maintaining a repressive chromatin state of the Foxp3 promoter. | The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.
Liu B, Tahk S, Yee KM, Fan G, Shuai K., Free PMC Article | 11/13/2010 |
| Pias1-dependent SUMOylation influences Gli protein activity | SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.
Cox B, Briscoe J, Ulloa F., Free PMC Article | 11/6/2010 |
| SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by specifically inhibiting the LIF-induced JAK1/STAT1/STAT3 pathway. | SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
Diao Y, Wang X, Wu Z., Free PMC Article | 01/21/2010 |
| PIAS1 promotes TGFbeta-induced activation of SM alpha-actin gene expression at least in part by promoting sumoylation and degradation of the TCE repressor protein, KLF4. | PIAS1 mediates TGFbeta-induced SM alpha-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation.
Kawai-Kowase K, Ohshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M., Free PMC Article | 01/21/2010 |
| These data suggest that AIRE and PIAS1 interact functionally to regulate the activities of the target genes of AIRE. | Functional interaction of AIRE with PIAS1 in transcriptional regulation.
Ilmarinen T, Kangas H, Kytömaa T, Eskelin P, Saharinen J, Seeler JS, Tanhuanpää K, Chan FY, Slattery RM, Alakurtti K, Palvimo JJ, Ulmanen I. | 01/21/2010 |