| Characterization of the A-type potassium current in murine gastric fundus smooth muscles. | Characterization of the A-type potassium current in murine gastric fundus smooth muscles.
Amberg GC, Lee JY, Koh SD, Sanders KM., Free PMC Article | 11/13/2021 |
| In ERaKO but not ERaKO mice, the mRNA of Kv4.3 was selectively increased... E2 negatively regulates the density of Ito through ERa, this highlights a potential role for this female hormone in modulating cardiac electrical activity. | Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart.
El Gebeily G, El Khoury N, Mathieu S, Brouillette J, Fiset C. | 05/28/2016 |
| Data show that potassium channel Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-). | Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.
Liu J, Kim KH, Morales MJ, Heximer SP, Hui CC, Backx PH., Free PMC Article | 05/7/2016 |
| The gain-of-function SCNA overexpressing dopamine substantia nigra neurons was in part mediated by an increase of their intrinsic pacemaker frequency caused by a redox-dependent impairment of Kv4.3 | Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels.
Subramaniam M, Althof D, Gispert S, Schwenk J, Auburger G, Kulik A, Fakler B, Roeper J., Free PMC Article | 07/25/2015 |
| The protein levels of KV4.3 and KV2.2 were up-regulated in the hypertrophic smooth muscle cell membrane. | Voltage dependent potassium channel remodeling in murine intestinal smooth muscle hypertrophy induced by partial obstruction.
Liu DH, Huang X, Guo X, Meng XM, Wu YS, Lu HL, Zhang CM, Kim YC, Xu WX., Free PMC Article | 01/17/2015 |
| The experiments here demonstrate that Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons. | A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.
Carrasquillo Y, Burkhalter A, Nerbonne JM., Free PMC Article | 01/12/2013 |
| Taken together, these data suggest that nerve injury causes an epigenetic silencing of K(v)4.3 gene mediated through transcriptional suppressor NRSF in the DRG. | Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury.
Uchida H, Sasaki K, Ma L, Ueda H. | 05/10/2010 |
| Kv4.3 channel alpha-subunit is found to be one of the components (along with Kv4.2 and Kv1.4) that propagates the voltage-gated potassium current in pyramidal cortical neurons. | Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.
Norris AJ, Nerbonne JM., Free PMC Article | 05/3/2010 |
| Downregulation of Kv4.3 and Kv1.5 transcripts by estrogen are one mechanism defining gender-related differences in mouse ventricular repolarization. | Estrogen contributes to gender differences in mouse ventricular repolarization.
Saito T, Ciobotaru A, Bopassa JC, Toro L, Stefani E, Eghbali M., Free PMC Article | 01/21/2010 |
| N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate. | Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation.
Liang P, Wang H, Chen H, Cui Y, Gu L, Chai J, Wang K. | 01/21/2010 |
| NO and NO donors inhibited I(Kv4.3) in a concentration- and voltage-dependent manner. | Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1).
Gómez R, Núñez L, Vaquero M, Amorós I, Barana A, de Prada T, Macaya C, Maroto L, Rodríguez E, Caballero R, López-Farré A, Tamargo J, Delpón E. | 01/21/2010 |
| Principal neurons of mouse medial nucleus of the trapezoid body possess a small, rapidly inactivating transient outward current (or A-current) that is mediated by Kv4.3 subunits. | Kv4 (A-type) potassium currents in the mouse medial nucleus of the trapezoid body.
Johnston J, Griffin SJ, Baker C, Forsythe ID. | 01/21/2010 |
| The results presented here suggest that, in contrast with Kv4.2, Kv4.3 is not required for the generation of functional mouse ventricular I(to,f) channels. | Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles.
Niwa N, Wang W, Sha Q, Marionneau C, Nerbonne JM., Free PMC Article | 01/21/2010 |
| Ativation of AT1 receptors by Angioteinsin II or stretch specifically destabilizes cardiac myocyte Kv4.3 channel mRNA by activating NADPH oxidase. | Angiotensin II and stretch activate NADPH oxidase to destabilize cardiac Kv4.3 channel mRNA.
Zhou C, Ziegler C, Birder LA, Stewart AF, Levitan ES., Free PMC Article | 01/21/2010 |
| The results show that Kv4.3 is concentrated in layer 1, the bottom of layer 2/3, and in layers 4 and 5/6. | Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.
Burkhalter A, Gonchar Y, Mellor RL, Nerbonne JM., Free PMC Article | 01/21/2010 |