| Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling. | Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
Wei ZX, Cai XX, Fei YD, Wang Q, Hu XL, Li C, Hou JW, Yang YL, Chen TZ, Xu XL, Wang YP, Li YG., Free PMC Article | 02/21/2024 |
| scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma. | scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma.
Kim HJ, Cha S, Choi JS, Lee JY, Kim KE, Kim JK, Kim J, Moon SY, Lee SHS, Park K, Won SY., Free PMC Article | 11/28/2023 |
| Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance. | Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance.
Huang Y, Zhou JH, Zhang H, Canfran-Duque A, Singh AK, Perry RJ, Shulman GI, Fernandez-Hernando C, Min W., Free PMC Article | 05/14/2022 |
| Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome. | Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.
Yang B, Huang Y, Zhang H, Huang Y, Zhou HJ, Young L, Xiao H, Min W. | 01/23/2021 |
| Thioredoxin-2 impacts the inflammatory response via suppression of NF-kappaB and MAPK signaling in sepsis shock. | Thioredoxin-2 impacts the inflammatory response via suppression of NF-κB and MAPK signaling in sepsis shock.
Wang X, Xing Y, Tang Z, Tang Y, Shen J, Zhang F. | 10/24/2020 |
| Loss of TXN2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy. | Loss of thioredoxin 2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy.
Hu C, Zhang H, Qiao Z, Wang Y, Zhang P, Yang D. | 09/21/2019 |
| The ventral signal observed from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord. | Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
Pirson M, Knoops B. | 07/16/2016 |
| TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity | Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.
Liu Y, Yang Y, Dong H, Cutler RG, Strong R, Mattson MP., Free PMC Article | 04/30/2016 |
| An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species. | Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.
Huang Q, Zhou HJ, Zhang H, Huang Y, Hinojosa-Kirschenbaum F, Fan P, Yao L, Belardinelli L, Tellides G, Giordano FJ, Budas GR, Min W., Free PMC Article | 06/20/2015 |
| The SirT1 regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase, catalase, peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2, and uncoupling protein 2. | SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex.
Olmos Y, Sánchez-Gómez FJ, Wild B, García-Quintans N, Cabezudo S, Lamas S, Monsalve M., Free PMC Article | 12/6/2014 |
| This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression. | Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiency.
Kunde SS, Roede JR, Vos MB, Orr ML, Go YM, Park Y, Ziegler TR, Jones DP., Free PMC Article | 05/19/2012 |
| Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. | Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
Hanschmann EM, Lönn ME, Schütte LD, Funke M, Godoy JR, Eitner S, Hudemann C, Lillig CH., Free PMC Article | 01/29/2011 |
| Data show that Nrf2 activity was increased in WT MEFs at the 0 or -46 mV conditions, but was inhibited in Trx2 Tg MEFs under the same conditions. | Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species.
Imhoff BR, Hansen JM. | 01/21/2010 |
| Trx2 is an endogenous regulator of the mitochondrial permeability transition. | Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition.
He M, Cai J, Go YM, Johnson JM, Martin WD, Hansen JM, Jones DP., Free PMC Article | 01/21/2010 |
| Homozygous mutant embryos do not survive to birth and die after implantation at Theiler stage 15/16. | The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice.
Nonn L, Williams RR, Erickson RP, Powis G., Free PMC Article | 01/21/2010 |
| the rapid E2-mediated activation of the Txn pathway is an important step in the response of the mammalian uterus to estrogen. | Estradiol regulates the thioredoxin antioxidant system in the mouse uterus.
Deroo BJ, Hewitt SC, Peddada SD, Korach KS. | 01/21/2010 |