| Pharmacologic inhibition or knock-down of downstream targets of ATF6a, protein disulfide isomerases (PDI) and ERO1b, a thiol oxidase that is involved in the re-oxidation of PDIs also independently induced pronounced killing of osteosarcoma (OS) cells following chemotherapy. | ATF6α Activation Enhances Survival against Chemotherapy and Serves as a Prognostic Indicator in Osteosarcoma.
Yarapureddy S, Abril J, Foote J, Kumar S, Asad O, Sharath V, Faraj J, Daniel D, Dickman P, White-Collins A, Hingorani P, Sertil AR., Free PMC Article | 11/30/2019 |
| This peptide, Ac-VDTTD-AFC, was efficiently cleaved by purified caspase-2 and auto-activating caspase-2 in mammalian cells, and exhibited better selectivity for caspase-2 relative to caspase-3 than reagents that are currently available. | Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262.
Hansen HG, Søltoft CL, Schmidt JD, Birk J, Appenzeller-Herzog C, Ellgaard L., Free PMC Article | 01/13/2018 |
| GJB2 and ERO1LB are implicated in pancreatic cancer progression and can be used to predict patient survival | Genome-scale analysis identifies GJB2 and ERO1LB as prognosis markers in patients with pancreatic cancer.
Zhu T, Gao YF, Chen YX, Wang ZB, Yin JY, Mao XY, Li X, Zhang W, Zhou HH, Liu ZQ., Free PMC Article | 10/14/2017 |
| upregulated in pancreatic neuroendocrine tumors | The Immunohistochemical Evaluation of Solid Pseudopapillary Tumors of the Pancreas and Pancreatic Neuroendocrine Tumors Reveals ERO1Lβ as a New Biomarker.
Xie J, Zhu Y, Chen H, Shi M, Gu J, Zhang J, Shen B, Deng X, Zhan X, Peng C., Free PMC Article | 06/4/2016 |
| In the present work, it was shown that recombinant human Ero1beta is twice as active as Ero1alpha in enzymatic assays. | The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation.
Wang L, Zhu L, Wang CC. | 03/19/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The lack of correlation between changes in SAT adiponectin gene and protein expression and its circulating levels suggests that adipose tissue synthesis and release of adiponectin are highly regulated pathways. | Response of adiponectin and its receptors to changes in metabolic state after gastric bypass surgery: dissociation between adipose tissue expression and circulating levels.
Savu MK, Phillips SA, Oh DK, Park K, Gerlan C, Ciaraldi TP, Henry RR. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesThe variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.
Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN. | 04/23/2008 |
| analysis of Ero1beta tissue distribution and dimerization | Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta.
Dias-Gunasekara S, Gubbens J, van Lith M, Dunne C, Williams JA, Kataky R, Scoones D, Lapthorn A, Bulleid NJ, Benham AM. | 01/21/2010 |
| glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum | Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.
Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R. | 01/21/2010 |
| the Ero FAD binding domain is critical for conformational stability, allowing Ero proteins to withstand stress conditions that cause client proteins to misfold | Mutations in the FAD binding domain cause stress-induced misoxidation of the endoplasmic reticulum oxidoreductase Ero1beta.
Dias-Gunasekara S, van Lith M, Williams JA, Kataky R, Benham AM. | 01/21/2010 |
| Ero1alpha and Ero1beta are retained in the endoplasmic reticulum by interactions with PDI and ERp44 | Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.
Otsu M, Bertoli G, Fagioli C, Guerini-Rocco E, Nerini-Molteni S, Ruffato E, Sitia R. | 01/21/2010 |