| Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway. | Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway.
Li L, Chen Q, Qin Y, Yu G, Qi T, Sui H, Qi X, Huang L. | 11/13/2024 |
| A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage. | A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage.
Kitami M, Kaku M, Thant L, Maeda T., Free PMC Article | 10/30/2024 |
| The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors. | The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.
Tsukamoto T. | 10/18/2024 |
| Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice. | Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice.
Witucki Ł, Jakubowski H. | 10/3/2024 |
| Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction. | Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction.
Chen K, Huang B, Feng J, Hu Z, Fan S, Ren S, Tian H, Abdulkarem M M AM, Wang X, Tuo Y, Liang X, Xie H, He R, Li G., Free PMC Article | 09/13/2024 |
| mTOR aggravated CD4[+] T cell pyroptosis by regulating the PPARgamma-Nrf2 pathway in sepsis. | mTOR aggravated CD4(+) T cell pyroptosis by regulating the PPARγ-Nrf2 pathway in sepsis.
Zhao G, Xie Y, Lei X, Guo R, Cui N. | 09/9/2024 |
| ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR. | ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Li C, Cai Y, Chen Y, Tong J, Li Y, Liu D, Wang Y, Li Z, Wang Y, Li Q., Free PMC Article | 08/30/2024 |
| Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy. | Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.
Qi J, Wu Y, Guo Z, Zhu S, Xiong J, Hu F, Liang X, Ye X. | 07/13/2024 |
| The role of autophagy regulated by the PI3K/AKT/mTOR pathway and innate lymphoid cells in eosinophilic chronic sinusitis with nasal polyps. | The role of autophagy regulated by the PI3K/AKT/mTOR pathway and innate lymphoid cells in eosinophilic chronic sinusitis with nasal polyps.
Zhuo JJ, Wang C, Kai YL, Xu YY, Cheng KJ., Free PMC Article | 06/28/2024 |
| PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis. | PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis.
Xu X, Bok I, Jasani N, Wang K, Chadourne M, Mecozzi N, Deng O, Welsh EA, Kinose F, Rix U, Karreth FA., Free PMC Article | 06/27/2024 |
| Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration. | Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
Zhao R, Huang S, Li J, Gu A, Fu M, Hua W, Mao Y, Lei QY, Lu B, Wen W., | 06/25/2024 |
| Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways. | Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways.
Zheng D, Cui C, Ye C, Shao C, Zha X, Xu Y, Liu X, Wang C., Free PMC Article | 05/13/2024 |
| Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling. | Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling.
Liu H, Chen Y, Huang Y, Wei L, Ran J, Li Q, Tian Y, Luo Z, Yang L, Liu H, Yin G, Xie Q., Free PMC Article | 05/10/2024 |
| Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention. | Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention.
Fu Y, Xiang Y, Zha J, Chen G, Dong Z. | 03/29/2024 |
| Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation. | Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Huang N, Winans T, Wyman B, Oaks Z, Faludi T, Choudhary G, Lai ZW, Lewis J, Beckford M, Duarte M, Krakko D, Patel A, Park J, Caza T, Sadeghzadeh M, Morel L, Haas M, Middleton F, Banki K, Perl A., Free PMC Article | 03/28/2024 |
| Parasite-induced IFN-gamma regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death. | Parasite-induced IFN-γ regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death.
Martin AT, Giri S, Safronova A, Eliseeva SI, Kwok SF, Yarovinsky F., Free PMC Article | 03/7/2024 |
| PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway. | PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway.
Chen H, Li L, Liu H, Qin P, Chen R, Liu S, Xiong H, Li Y, Yang Z, Xie M, Yang H, Jiang Q. | 03/6/2024 |
| Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway. | Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway.
Kim SM, Kim DY, Park J, Moon YA, Han IO., Free PMC Article | 03/1/2024 |
| Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer. | Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer.
Chen M, Wang G, Xu Z, Sun J, Liu B, Chang L, Gu J, Ruan Y, Gao X, Song S. | 02/28/2024 |
| The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. | The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function.
Nguyen LH, Xu Y, Nair M, Bordey A., Free PMC Article | 02/28/2024 |
| mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms. | mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.
Ali Y, Gomez-Sanchez CE, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez EP., Free PMC Article | 02/27/2024 |
| CXCR5 + CD8 + T Cell-mediated Suppression of Humoral Alloimmunity and AMR in Mice Is Optimized With mTOR and Impaired With Calcineurin Inhibition. | CXCR5 + CD8 + T Cell-mediated Suppression of Humoral Alloimmunity and AMR in Mice Is Optimized With mTOR and Impaired With Calcineurin Inhibition.
Han JL, Zimmerer JM, Zeng Q, Chaudhari SR, Hart M, Satoskar AA, Abdel-Rasoul M, Breuer CK, Bumgardner GL., | 02/23/2024 |
| Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy. | Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.
Lee YY, Ha J, Kim YS, Ramani S, Sung S, Gil ES, Choo OS, Jang JH, Choung YH., Free PMC Article | 01/11/2024 |
| Branched-chain amino acid catabolic defect in vascular smooth muscle cells drives thoracic aortic dissection via mTOR hyperactivation. | Branched-chain amino acid catabolic defect in vascular smooth muscle cells drives thoracic aortic dissection via mTOR hyperactivation.
Yu L, Huang T, Zhao J, Zhou Z, Cao Z, Chi Y, Meng S, Huang Y, Xu Y, Xia L, Jiang H, Yin Z, Wang H. | 12/29/2023 |
| PA suppresses antitumor immunity of T cells by disturbing mitochondrial activity through Akt/mTOR-mediated Ca[2+] flux. | PA suppresses antitumor immunity of T cells by disturbing mitochondrial activity through Akt/mTOR-mediated Ca(2+) flux.
Sun S, Xu H, Zhao W, Li Q, Yuan Y, Zhang G, Li S, Wang B, Zhang W, Gao X, Zheng J, Zhang Q. | 12/21/2023 |