| Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions. | Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.
Xian G, Huang R, Xu M, Zhao H, Xu X, Chen Y, Ren H, Xu D, Zeng Q., Free PMC Article | 08/7/2024 |
| Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Osteoporosis via MicroRNA-27a-Induced Inhibition of DKK2-Mediated Wnt/beta-Catenin Pathway. | Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Osteoporosis via MicroRNA-27a-Induced Inhibition of DKK2-Mediated Wnt/β-Catenin Pathway.
Wang Y, Zhou X, Wang D. | 04/9/2022 |
| Dickkopf-2 knockdown protects against classic macrophage polarization and lipid loading by activation of Wnt/beta-catenin signaling. | Dickkopf-2 knockdown protects against classic macrophage polarization and lipid loading by activation of Wnt/β-catenin signaling.
Zhang Y, Wu H, He R, Ye C, Chen H, Wang J, Li Z. | 12/11/2021 |
| Dickkopf (Dkk)-2 is a beige fat-enriched adipokine to regulate adipogenesis. | Dickkopf (Dkk)-2 is a beige fat-enriched adipokine to regulate adipogenesis.
Yang J, Shi BY. | 09/11/2021 |
| In the absence of Dkk2, Wnt/beta-catenin signaling activity is initially broadly elevated in embryonic plantar skin and gradually becomes patterned, mimicking follicular development in normally haired areas. | Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.
Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, Wu D, Li Y, Xu M, Millar SE., Free PMC Article | 12/7/2019 |
| Reprogramming of damaged erectile tissue toward neurovascular repair by use of a DKK2 therapeutic protein may represent viable treatment option for this condition. | Dickkopf2 rescues erectile function by enhancing penile neurovascular regeneration in a mouse model of cavernous nerve injury.
Ghatak K, Yin GN, Choi MJ, Limanjaya A, Minh NN, Ock J, Song KM, Kang DH, Kwon YG, Kim HM, Ryu JK, Suh JK., Free PMC Article | 07/20/2019 |
| Data (including data from studies in transgenic mice) suggest that Dkk2 secreted from pericytes promotes angiogenesis and neurogenesis/neural regeneration via Angpt1/Tie2/Wnt signaling; here, overexpression of Dkk2 in diabetic mice enhances penile angiogenesis/neural regeneration and restores erectile function. (Dkk2 = dickkopf-2; Angpt1= angiopoietin-1; Tie2 = endothelial-specific receptor tyrosine kinase Tie2) | Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway.
Yin GN, Jin HR, Choi MJ, Limanjaya A, Ghatak K, Minh NN, Ock J, Kwon MH, Song KM, Park HJ, Kim HM, Kwon YG, Ryu JK, Suh JK. | 06/30/2018 |
| Dkk2 deletion results in alterations of liver morphology leading to an increased frequency of liver cancer | Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice.
Maass T, Marquardt J, Lee JS, Krupp M, Scholz-Kreisel P, Mogler C, Schirmacher P, Müller M, Westphal H, Galle PR, Teufel A., Free PMC Article | 01/13/2018 |
| Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development. | Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3.
Wang Y, Fang R, Yuan Y, Pan M, Hu M, Zhou Y, Shen B, Zhao J. | 07/22/2017 |
| these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists. | Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.
Jia S, Kwon HE, Lan Y, Zhou J, Liu H, Jiang R., Free PMC Article | 06/10/2017 |
| These findings demonstrate that DKK1 and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis. | Distinct roles of DKK1 and DKK2 in tumor angiogenesis.
Park H, Jung HY, Choi HJ, Kim DY, Yoo JY, Yun CO, Min JK, Kim YM, Kwon YG., Free PMC Article | 08/23/2014 |
| Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation | Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.
Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R., Free PMC Article | 02/23/2013 |
| Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism | Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Li X, Shan J, Chang W, Kim I, Bao J, Lee HJ, Zhang X, Samuel VT, Shulman GI, Liu D, Zheng JJ, Wu D., Free PMC Article | 10/6/2012 |
| Both Dkk1 and Dkk2 inhibit Wnt signaling that regulates early myocardial proliferation; each compensates for loss of the other in that role. | Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
Phillips MD, Mukhopadhyay M, Poscablo C, Westphal H., Free PMC Article | 08/11/2012 |
| there are distinct functions of DKK1 and DKK2 in controlling angiogenesis | The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.
Min JK, Park H, Choi HJ, Kim Y, Pyun BJ, Agrawal V, Song BW, Jeon J, Maeng YS, Rho SS, Shim S, Chai JH, Koo BK, Hong HJ, Yun CO, Choi C, Kim YM, Hwang KC, Kwon YG., Free PMC Article | 07/16/2011 |
| Dkk2 expression is associated with uterine receptivity changes as well as the process of decidualization and that it might play important roles through inhibition of canonical Wnt signaling in the periimplantation uterus. | Expression and regulation of Dickkopf2 during periimplantation in mice.
Zhang Y, Peng S, Kuang H, Chen Q, Liu S, Zhang L, Duan E. | 01/21/2010 |
| Study identified novel expression domains for the Wnt antagonists Sfrp1, Sfrp3, Sfrp5 as well as Dkk2 and Dkk3. | Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.
Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S. | 01/21/2010 |
| analysis of the structural basis of the interaction between Dkk and low density lipoprotein receptor-related protein (LRP) 5/6 | Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.
Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ., Free PMC Article | 01/21/2010 |
| These data suggest that activation of Dkk2 by PITX2 provides a mechanism to locally suppress canonical Wnt signaling activity during eye development | The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.
Gage PJ, Qian M, Wu D, Rosenberg KI., Free PMC Article | 01/21/2010 |
| WNT signaling attenuation by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF | Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF.
Fujita K, Janz S., Free PMC Article | 01/21/2010 |
| Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium | Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium.
Mukhopadhyay M, Gorivodsky M, Shtrom S, Grinberg A, Niehrs C, Morasso MI, Westphal H. | 01/21/2010 |
| Dkks were involved in craniofacial developmental processes, including facial outgrowth, myogenesis, osteogenesis, palatogenesis, olfactory epithelium and tooth development; and the expression persisted to postnatal stage in the muscles and bones. | Dkk1, -2, and -3 expression in mouse craniofacial development.
Nie X. | 01/21/2010 |
| Dkk2 was localized in the perichondral mesenchyme outlining the anterior cranial base in embryogenesis. | Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice.
Nie X, Luukko K, Fjeld K, Kvinnsland IH, Kettunen P. | 01/21/2010 |