| Bassoon inhibits proteasome activity via interaction with PSMB4. | Bassoon inhibits proteasome activity via interaction with PSMB4.
Montenegro-Venegas C, Fienko S, Anni D, Pina-Fernández E, Frischknecht R, Fejtova A., Free PMC Article | 03/6/2021 |
| FoxM1 transcriptionally activates the PSMB4 expression level in cervical cancer cells. | A novel FoxM1-PSMB4 axis contributes to proliferation and progression of cervical cancer.
Zhou DM, Liu J, Liu F, Luo GW, Li HT, Zhang R, Chen BL, Hua W. | 08/1/2020 |
| High PSMB4 expression is associated with breast cancer. | PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis.
Wang H, He Z, Xia L, Zhang W, Xu L, Yue X, Ru X, Xu Y. | 11/24/2018 |
| PSMB4 knockdown decreased the expression levels of MMP2, MMP9 and cathepsin B and decreased proliferation, migration and invasion abilities in human GBM cells. | Interference with PSMB4 Expression Exerts an Anti-Tumor Effect by Decreasing the Invasion and Proliferation of Human Glioblastoma Cells.
Cheng YC, Tsai WC, Sung YC, Chang HH, Chen Y. | 03/31/2018 |
| We further identified miR-148b as a negative regulator of proteasome beta-4 subunit. Enforced expression of miR-148b resulted in vitro growth inhibition of melanoma cells, whereas this inhibition was further abolished by enforced expression of proteasome beta-4 subunit | Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b.
Zhang X, Lin D, Lin Y, Chen H, Zou M, Zhong S, Yi X, Han S. | 07/15/2017 |
| Our findings implied that PSMB4 is involved in the progression of EOC (epithelial ovarian cancer) and could serve as potential therapeutical target of EOC. These data suggested that PSMB4 may promote cell proliferation via the NF-kappaB-target gene in EOC (epithelial ovarian cancer) | PSMB4 expression associates with epithelial ovarian cancer growth and poor prognosis.
Liu R, Lu S, Deng Y, Yang S, He S, Cai J, Qiang F, Chen C, Zhang W, Zhao S, Qian L, Mao G, Wang Y. | 07/1/2017 |
| Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-kappaB-miR-21 signaling, which may represent promising targets for novel specific therapies. | PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling.
Zheng P, Guo H, Li G, Han S, Luo F, Liu Y. | 05/2/2015 |
| Data indicate that recruitment of proteasomes into mutant huntingtin (mHTT) protein initiated inclusion bodies (IBs) was observed when the PSMB4-GFP was co-expressed with mHTT. | Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies.
Schipper-Krom S, Juenemann K, Jansen AH, Wiemhoefer A, van den Nieuwendijk R, Smith DL, Hink MA, Bates GP, Overkleeft H, Ovaa H, Reits E. | 03/1/2014 |
| proteasome subunit beta type 4 (PSMB4), the beta7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. | Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4.
Lee KM, Lee J, Park CS. | 03/23/2013 |
| While 26 proteasome dysfunction is observed in Parkinson's disease (PD), diverse mutations in the parkin gene are linked to early-onset autosomal-recessive forms of familial PD. | Parkin directly modulates 26S proteasome activity.
Um JW, Im E, Lee HJ, Min B, Yoo L, Yoo J, Lübbert H, Stichel-Gunkel C, Cho HS, Yoon JB, Chung KC., Free PMC Article | 09/27/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.
Wong ML, Dong C, Maestre-Mesa J, Licinio J. | 06/4/2008 |