| Mitochondrial Translocase TOMM22 Is Overexpressed in Pancreatic Cancer and Promotes Aggressive Growth by Modulating Mitochondrial Protein Import and Function. | Mitochondrial Translocase TOMM22 Is Overexpressed in Pancreatic Cancer and Promotes Aggressive Growth by Modulating Mitochondrial Protein Import and Function.
Haastrup MO, Vikramdeo KS, Anand S, Khan MA, Carter JE, Singh S, Singh AP, Dasgupta S. | 02/5/2024 |
| Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. | Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors.
Su J, Liu D, Yang F, Zuo MQ, Li C, Dong MQ, Sun S, Sui SF., Free PMC Article | 07/2/2022 |
| A directed proteomic approach discovered the novel interaction of BKCa with Tom22, a component of the mitochondrion outer membrane import system, and the adenine nucleotide translocator (ANT). | The mitochondrial BK(Ca) channel cardiac interactome reveals BK(Ca) association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator.
Zhang J, Li M, Zhang Z, Zhu R, Olcese R, Stefani E, Toro L., Free PMC Article | 05/13/2017 |
| Tom22 is essential for metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mouse Leydig MA-10 and human adrenal NCI cells. | An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.
Rajapaksha M, Kaur J, Prasad M, Pawlak KJ, Marshall B, Perry EW, Whittal RM, Bose HS., Free PMC Article | 07/30/2016 |
| Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery. | The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Bertolin G, Ferrando-Miguel R, Jacoupy M, Traver S, Grenier K, Greene AW, Dauphin A, Waharte F, Bayot A, Salamero J, Lombès A, Bulteau AL, Fon EA, Brice A, Corti O. | 06/21/2014 |
| Studies indicate that PUMA and TOMM22 as potential targets for miRNA-BART viral transcripts. | The role of miRNAs and EBV BARTs in NPC.
Marquitz AR, Raab-Traub N., Free PMC Article | 06/30/2012 |
| The interaction with the cytosolic domain of Tom22 helps Bax to acquire a conformation able to interact with the outer mitochondrial membrane. | The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast.
Renault TT, Grandier-Vazeille X, Arokium H, Velours G, Camougrand N, Priault M, Teijido O, Dejean LM, Manon S. | 03/10/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| We have identified TOM22, a component of the translocase of the outer mitochondrial membrane (TOM), as a mitochondrial receptor of Bax. | TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.
Bellot G, Cartron PF, Er E, Oliver L, Juin P, Armstrong LC, Bornstein P, Mihara K, Manon S, Vallette FM. | 01/21/2010 |
| the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface | Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity.
Yano M, Terada K, Mori M. | 01/21/2010 |
| Levels of Tom22 in mitochondria accelerate the rate of Tom7 assembly into the mature TOM complex. | Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane.
Johnston AJ, Hoogenraad J, Dougan DA, Truscott KN, Yano M, Mori M, Hoogenraad NJ, Ryan MT. | 01/21/2010 |