| CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function. | CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function.
Li Y, Wu J., Free PMC Article | 09/23/2024 |
| The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype. | The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype.
Traum A, Jehle S, Waxmann Y, Litmeyer AS, Berghöfer H, Bein G, Dammann R, Perniss A, Burg-Roderfeld M, Sachs UJ, Bayat B., Free PMC Article | 03/20/2024 |
| Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer. | Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer.
Liao W, Li W, Li Y, Liu T, Wang Y, Feng D, Shen F. | 02/4/2023 |
| Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation. | Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.
Marino SF, Jerke U, Rolle S, Daumke O, Kettritz R., Free PMC Article | 04/30/2022 |
| The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology. | The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology.
Astarita JL, Keerthivasan S, Husain B, Şenbabaoğlu Y, Verschueren E, Gierke S, Pham VC, Peterson SM, Chalouni C, Pierce AA, Lill JR, Gonzalez LC, Martinez-Martin N, Turley SJ., Free PMC Article | 01/8/2022 |
| CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. | CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Kim MC, Borcherding N, Ahmed KK, Voigt AP, Vishwakarma A, Kolb R, Kluz PN, Pandey G, De U, Drashansky T, Helm EY, Zhang X, Gibson-Corley KN, Klesney-Tait J, Zhu Y, Lu J, Lu J, Huang X, Xiang H, Cheng J, Wang D, Wang Z, Tang J, Hu J, Wang Z, Liu H, Li M, Zhuang H, Avram D, Zhou D, Bacher R, Zheng SG, Wu X, Zakharia Y, Zhang W., Free PMC Article | 10/23/2021 |
| Characterization of CD177-reactive iso- and auto-antibodies. | Characterization of CD177-reactive iso- and auto-antibodies.
Traum A, Hofmann C, Haas S, Schmidt S, Bein G, Sachs UJ, Bayat B. | 07/24/2021 |
| Relationship between CD177 and the vasculogenic mimicry, clinicopathological parameters, and prognosis of epithelial ovarian cancer. | Relationship between CD177 and the vasculogenic mimicry, clinicopathological parameters, and prognosis of epithelial ovarian cancer.
Jiang J, Chen Y, Zhang M, Zhou H, Wu H. | 06/26/2021 |
| The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis. | The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis.
Dahlstrand Rudin A, Amirbeagi F, Davidsson L, Khamzeh A, Thorbert Mros S, Thulin P, Welin A, Björkman L, Christenson K, Bylund J. | 03/27/2021 |
| Cancer cell-intrinsic function of CD177 in attenuating beta-catenin signaling. | Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling.
Kluz PN, Kolb R, Xie Q, Borcherding N, Liu Q, Luo Y, Kim MC, Wang L, Zhang Y, Li W, Stipp C, Gibson-Corley KN, Zhao C, Qi HH, Bellizzi A, Tao AW, Sugg S, Weigel RJ, Zhou D, Shen X, Zhang W., Free PMC Article | 11/21/2020 |
| A novel nonsense mutation found in the CD177 gene of Thai individuals with the HNA-2 null phenotype. | A novel nonsense mutation found in the CD177 gene of Thai individuals with the HNA-2 null phenotype.
Siriphanthong K, Petvises S, Thanongsaksrikul J, Intharanut K, Nathalang O. | 11/21/2020 |
| Generation of pancreatic beta cells from CD177(+) anterior definitive endoderm. | Generation of pancreatic β cells from CD177(+) anterior definitive endoderm.
Mahaddalkar PU, Scheibner K, Pfluger S, Ansarullah, Sterr M, Beckenbauer J, Irmler M, Beckers J, Knöbel S, Lickert H. | 11/21/2020 |
| These results suggested that the increase of CD177(pos) neutrophils was associated with Kawasaki disease. | Genome-wide transcriptome analysis to further understand neutrophil activation and lncRNA transcript profiles in Kawasaki disease.
Ko TM, Chang JS, Chen SP, Liu YM, Chang CJ, Tsai FJ, Lee YC, Chen CH, Chen YT, Wu JY., Free PMC Article | 06/27/2020 |
| Our findings implicate CD177 as a biomarker for bevacizumab and suggest VEGF/Ang2 inhibition as a strategy to overcome neutrophil associated resistance to anti-angiogenic treatment. | Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer.
Schiffmann LM, Fritsch M, Gebauer F, Günther SD, Stair NR, Seeger JM, Thangarajah F, Dieplinger G, Bludau M, Alakus H, Göbel H, Quaas A, Zander T, Hilberg F, Bruns CJ, Kashkar H, Coutelle O., Free PMC Article | 09/21/2019 |
| High CD177 expression is associated with Biliary Atresia. | The Role of Neonatal Gr-1(+) Myeloid Cells in a Murine Model of Rhesus-Rotavirus-Induced Biliary Atresia.
Zhang R, Lin Z, Fu M, Guan X, Yu J, Zhong W, Zeng J, Lui VCH, Tam PKH, Lamb JR, Xia H, Chen Y. | 08/31/2019 |
| Higher expression of CD177 in Kawasaki disease patients with typical presentation was associated with intravenous immunoglobulin resistance. | Increase expression of CD177 in Kawasaki disease.
Huang YH, Lo MH, Cai XY, Liu SF, Kuo HC., Free PMC Article | 04/13/2019 |
| Characterization of the CD177 interaction with the ANCA antigen proteinase 3 responsible for autoimmune diseases has been reported. | Characterization of the CD177 interaction with the ANCA antigen proteinase 3.
Jerke U, Marino SF, Daumke O, Kettritz R., Free PMC Article | 11/3/2018 |
| our results have highlighted for the first time an up-regulated transcriptomics and phenotypic expression of neutrophil CD177 in septic shock patients compared to healthy volunteers. | Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients.
Demaret J, Venet F, Plassais J, Cazalis MA, Vallin H, Friggeri A, Lepape A, Rimmelé T, Textoris J, Monneret G. | 12/9/2017 |
| CD177 signals in a beta2 integrin-dependent manner to orchestrate a set of activation-mediated mechanisms that impair human neutrophil migration. | CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.
Bai M, Grieshaber-Bouyer R, Wang J, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA., Free PMC Article | 11/25/2017 |
| Data show that CD177 protein is monoallelically expressed in neutrophils and neutrophil-differentiated hematopoietic stem cells (HSCs). | Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.
Eulenberg-Gustavus C, Bähring S, Maass PG, Luft FC, Kettritz R., Free PMC Article | 10/7/2017 |
| Abundance of CD177hi neutrophils correlates with homozygosity for CD177 reference allele, while heterozygosity for ectopic CD177P1 gene conversion correlates with increased CD177neg neutrophils, in which both CD177P1 partially incorporated allele and paired intact CD177 allele are transcribed | Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion.
Wu Z, Liang R, Ohnesorg T, Cho V, Lam W, Abhayaratna WP, Gatenby PA, Perera C, Zhang Y, Whittle B, Sinclair A, Goodnow CC, Field M, Andrews TD, Cook MC., Free PMC Article | 04/29/2017 |
| Data indicate that high percentage of CD177 antigen-positive neutrophils undergo dynamic change during sepsis. | CD177/NB1 receptor expression is dynamically regulated in sepsis patients.
Schreiber A, Jannerjahn A, Kettritz R. | 04/16/2016 |
| the CD177 SNP is the primary genetic determinant for HNA-2 deficiency and expression variations. The mechanistic delineation of HNA-2 genetics will enable the development of genetic tests for diagnosis and prognosis of HNA-2-related human diseases. | Genetic mechanism of human neutrophil antigen 2 deficiency and expression variations.
Li Y, Mair DC, Schuller RM, Li L, Wu J., Free PMC Article | 04/9/2016 |
| This is the first report showing a prognostic correlation between CD177 expression and solid tumor behavior. | Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer.
Toyoda T, Tsukamoto T, Yamamoto M, Ban H, Saito N, Takasu S, Shi L, Saito A, Ito S, Yamamura Y, Nishikawa A, Ogawa K, Tanaka T, Tatematsu M., Free PMC Article | 01/3/2015 |
| Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders. | CD177 expression on neutrophils: in search of a clonal assay for myeloid neoplasia by flow cytometry.
Meyerson HJ, Osei E, Schweitzer K, Blidaru G, Edinger A, Balog A. | 12/7/2013 |