| Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4. | Structural and dynamic changes in P-Rex1 upon activation by PIP(3) and inhibition by IP(4).
Ravala SK, Adame-Garcia SR, Li S, Chen CL, Cianfrocco MA, Silvio Gutkind J, Cash JN, Tesmer JJG., Free PMC Article | 08/14/2024 |
| PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age. | PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age.
Zhang H, Okuyama H, Jain A, Jadhav RR, Wu B, Sturmlechner I, Morales J, Ohtsuki S, Weyand CM, Goronzy JJ., Free PMC Article | 03/13/2024 |
| Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-beta1. | Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1.
Gao X, Lin X, Lin M, Lan Y, Wang Y, Wu R, Li J, Huang C, Zhong D., Free PMC Article | 09/12/2023 |
| Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM., Free PMC Article | 08/20/2022 |
| Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. | Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.
Lavictoire SJ, Jomaa D, Gont A, Jardine K, Cook DP, Lorimer IAJ., Free PMC Article | 12/18/2021 |
| Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis. | Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis.
Wan SC, Wu H, Li H, Deng WW, Xiao Y, Wu CC, Yang LL, Zhang WF, Sun ZJ. | 06/5/2021 |
| Gbetagamma recruits and activates P-Rex1 via two independent binding interfaces. | Gβγ recruits and activates P-Rex1 via two independent binding interfaces.
Cervantes-Villagrana RD, Beltrán-Navarro YM, García-Jiménez I, Adame-García SR, Olguín-Olguín A, Reyes-Cruz G, Vázquez-Prado J. | 05/29/2021 |
| The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. | The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.
Ravala SK, Hopkins JB, Plescia CB, Allgood SR, Kane MA, Cash JN, Stahelin RV, Tesmer JJG., Free PMC Article | 02/2/2021 |
| PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells. | PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells.
Clements ME, Johnson RW., Free PMC Article | 11/28/2020 |
| A multidomain assembly is key to the regulation of P-Rex1. | Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold.
Cash JN, Urata S, Li S, Ravala SK, Avramova LV, Shost MD, Gutkind JS, Tesmer JJG, Cianfrocco MA., Free PMC Article | 05/23/2020 |
| PREX1 is a favorable variable of prognosis for breast cancer patients. | Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (PREX1) is a Novel Predictor of Prognosis for Breast Cancer Patients: A Retrospective Case Series.
Zhong Y, Zhang J, Zhou Y, Mao F, Lin Y, Xu Y, Guan J, Shen S, Pan B, Wang C, Peng L, Huang X, Li Y, Cao X, Sun Q., Free PMC Article | 01/25/2020 |
| GTPase-deficient G-ALPHA-qQL and Galpha13QL variants formed stable complexes with G protein beta gamma, impairing its interaction with P-REX1. | Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gα(q) and Gα(13) proteins.
Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J., Free PMC Article | 05/4/2019 |
| type I PKA regulatory subunits (RIalpha) interact with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-REX1), a chemotactic Rac guanine exchange factor (RacGEF). RIalpha CNB-B domain is critical for the interaction with P-REX1, which was increased in RIalpha mutants, such as the acrodysostosis-associated mutant, that activate P-REX1 at basal cAMP levels. | cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.
Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J., Free PMC Article | 05/4/2019 |
| a novel role for GRK2 as a target of TCR signaling that is responsible for TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that signals via PI3Kgamma/PREX1 to mediate cytokine production. | GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion.
Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE., Free PMC Article | 03/2/2019 |
| Authors suggest that control of P-Rex1 activity depends on a highly dynamic interplay among distinct signalling routes and its multisite phosphorylation is controlled by the action of different kinases. | Multisite phosphorylation of P-Rex1 by protein kinase C.
Montero JC, Seoane S, García-Alonso S, Pandiella A., Free PMC Article | 03/24/2018 |
| PREX1 integrates dopamine receptor and phosphoinositide 3-kinase signaling to promote glioblastoma tumor cell invasion. | PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion.
Gont A, Daneshmand M, Woulfe J, Lavictoire SJ, Lorimer IA., Free PMC Article | 03/3/2018 |
| There is a significant association in the expression of P-Rex1 and MMP10 in human luminal breast cancer, and their co-expression is indicative of poor prognosis. | Characterization of a P-Rex1 gene signature in breast cancer cells.
Barrio-Real L, Wertheimer E, Garg R, Abba MC, Kazanietz MG., Free PMC Article | 02/10/2018 |
| Data suggest that PREX1 and PREX2 share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 is altered in many cancers. [REVIEW] | P-Rex1 and P-Rex2 RacGEFs and cancer.
Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA. | 12/30/2017 |
| upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 via phosphorylation of S339-CXCR4 in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2), IL-4, and IL-10 messenger RNA (mRNA) transcripts. | TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL.
Kremer KN, Dinkel BA, Sterner RM, Osborne DG, Jevremovic D, Hedin KE., Free PMC Article | 09/30/2017 |
| data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kinase and GPCR-stimulated signaling pathways | PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).
Barrows D, He JZ, Parsons R., Free PMC Article | 05/13/2017 |
| PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen. | PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.
Liu HJ, Ooms LM, Srijakotre N, Man J, Vieusseux J, Waters JE, Feng Y, Bailey CG, Rasko JE, Price JT, Mitchell CA., Free PMC Article | 05/7/2017 |
| An unexpected role for P-Rex1 and Rac1 activation in the genesis of prostate cancer stem cells and resistance to bevacizumab and sunitinib. | P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM., Free PMC Article | 01/14/2017 |
| P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism. | Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.
Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J., Free PMC Article | 08/13/2016 |
| findings suggest a vital role of P-Rex1 signaling in CA1 LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs | Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior.
Li J, Chai A, Wang L, Ma Y, Wu Z, Yu H, Mei L, Lu L, Zhang C, Yue W, Xu L, Rao Y, Zhang D., Free PMC Article | 06/4/2016 |
| The P-Rex1-Rac1 interface is critical for Rac1 activation in breast cancer cells. | The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM., Free PMC Article | 11/28/2015 |