| PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts. | PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts.
Zhang C, Mok J, Seong Y, Lau HC, Kim D, Yoon J, Oh SW, Park TS, Park J. | 02/12/2022 |
| Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2. | Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
Casella I, Ambrosio C. | 01/22/2022 |
| Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle. | Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
Mok J, Park TS, Kim S, Kim D, Choi CS, Park J. | 06/26/2021 |
| Upon high fat diet exposure, PKR1 (tcf-/-) mice displayed excessive fat deposition in the atrioventricular groove, perivascular area, and pericardium, which was accompanied by an impaired vascular network and cardiac dysfunction. | Prokineticin receptor-1-dependent paracrine and autocrine pathways control cardiac tcf21(+) fibroblast progenitor cell transformation into adipocytes and vascular cells.
Qureshi R, Kindo M, Arora H, Boulberdaa M, Steenman M, Nebigil CG., Free PMC Article | 07/6/2019 |
| The study shows that PK2beta ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through prokineticin receptor 1. | PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor.
Lattanzi R, Maftei D, Negri L, Fusco I, Miele R. | 11/17/2018 |
| The authors discovered that PKR1 regulates epicardial-mesenchymal transition (EMT) for epicardial-derived progenitor cell (EPDC), formation. This event affects at least three consequential steps during heart development: (i) EPDC and cardiomyocyte proliferation involved in thickening of an outer compact ventricular chamber wall, (ii) rhythmicity, (iii) formation of coronary circulation. | Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.
Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, Dolle P, Nebigil CG., Free PMC Article | 02/10/2018 |
| These results establish PKR1 via NFATc3 as a crucial modifier of mesenchymal-epithelial transition processing to the development of nephron. | Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development.
Arora H, Boulberdaa M, Qureshi R, Bitirim V, Messadeq N, Dolle P, Nebigil CG. | 08/26/2017 |
| show that MRAP2 significantly and specifically inhibits PKR1 signaling. | The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.
Chaly AL, Srisai D, Gardner EE, Sebag JA., Free PMC Article | 12/17/2016 |
| Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease. | Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.
Castelli M, Amodeo G, Negri L, Lattanzi R, Maftei D, Gotti C, Pistillo F, Onnis V, Congu C, Panerai AE, Sacerdote P, Franchi S., Free PMC Article | 08/13/2016 |
| These results suggest PKR1 to be a crucial player in the preadipocyte proliferation and differentiation. | Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity.
Szatkowski C, Vallet J, Dormishian M, Messaddeq N, Valet P, Boulberdaa M, Metzger D, Chambon P, Nebigil CG., Free PMC Article | 09/13/2014 |
| Loss of PKR1 causes renal and cardiac structural and functional changes because of deficits in survival signaling, mitochondrial, and progenitor cell functions in found both organs. | Genetic inactivation of prokineticin receptor-1 leads to heart and kidney disorders.
Boulberdaa M, Turkeri G, Urayama K, Dormishian M, Szatkowski C, Zimmer L, Messaddeq N, Laugel V, Dollé P, Nebigil CG. | 05/21/2011 |
| The functional characteristics of coronary endothelial cells depend on the expression of PKR1 and PKR2 levels and the divergent signaling pathways used by these receptors. | Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.
Guilini C, Urayama K, Turkeri G, Dedeoglu DB, Kurose H, Messaddeq N, Nebigil CG. | 04/12/2010 |
| Data show that the inflammation-induced up-regulation of PK2 was significantly less in pkr1 null mice than in WT and pkr2 null mice, demonstrating a role of PKR1 in setting PK2 levels during inflammation. | The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.
Giannini E, Lattanzi R, Nicotra A, Campese AF, Grazioli P, Screpanti I, Balboni G, Salvadori S, Sacerdote P, Negri L., Free PMC Article | 01/21/2010 |
| Cardiomyocyte-PKR1 signaling upregulates its own ligand prokineticin-2 that acts as a paracrine factor, triggering epicardial-derived progenitor cell proliferation/differentiation. | Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation.
Urayama K, Guilini C, Turkeri G, Takir S, Kurose H, Messaddeq N, Dierich A, Nebigil CG. | 01/21/2010 |
| PKR1 protein was localised to the labyrinth layer and showed the same pattern of expression as EG-VEGF in mouse placenta. | Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.
Hoffmann P, Feige JJ, Alfaidy N. | 01/21/2010 |
| Identification and molecular characterization of two closely related G protein-coupled receptors (prokineticin receptor) | Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.
Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY. | 01/21/2010 |