| Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1alpha pathway. | Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway.
Kang YJ, Song W, Lee SJ, Choi SA, Chae S, Yoon BR, Kim HY, Lee JH, Kim C, Cho JY, Kim HJ, Lee WW., Free PMC Article | 10/11/2024 |
| Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression. | Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression.
Wang W, Li Y, Tang L, Shi Y, Li W, Zou L, Zhang L, Cheng Y, Yuan Z, Zhu F, Duan Q. | 08/6/2024 |
| Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma. | Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma.
Zheng J, Liu Y, Wang J, Shi J, Li L, Jiang X, Tao L., Free PMC Article | 02/23/2024 |
| High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response. | High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response.
Pan J, Wang Y, Huang S, Mao S, Ling Q, Li C, Li F, Yu M, Huang X, Huang J, Lv Y, Li X, Ye W, Wang H, Wang J, Jin J. | 02/21/2024 |
| HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1. | HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
You H, Song G, Xu Z, Chen S, Shen W, Liu H, Deng B, Li J, Huang G., Free PMC Article | 02/21/2024 |
| Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression. | Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression.
Boskovic P, Wilke N, Man KH, Lichter P, Francois L, Radlwimmer B., Free PMC Article | 02/7/2024 |
| BCAT1, as a prognostic factor for HCC, can promote the development of liver cancer through activation of the AKT signaling pathway and EMT. | BCAT1, as a prognostic factor for HCC, can promote the development of liver cancer through activation of the AKT signaling pathway and EMT.
Ding Y, Wang X, Lu S, Lai A, Xie B, He X, Liu Q. | 02/14/2023 |
| BCAT1 redox function maintains mitotic fidelity. | BCAT1 redox function maintains mitotic fidelity.
Francois L, Boskovic P, Knerr J, He W, Sigismondo G, Schwan C, More TH, Schlotter M, Conway ME, Krijgsveld J, Hiller K, Grosse R, Lichter P, Radlwimmer B. | 10/29/2022 |
| Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer. | Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer.
Palanca-Ballester C, Hervas D, Villalba M, Valdes-Sanchez T, Garcia D, Alcoriza-Balaguer MI, Benet M, Martinez-Tomas R, Briones-Gomez A, Galbis-Caravajal J, Calvo A, Juan O, Lahoz A, Cases E, Sandoval J., Free PMC Article | 10/1/2022 |
| BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-kappaB pathway activation. | BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation.
Yu M, Zhao Q, Li J, Xu F, Zhang Z, Liu Y, Dai L, Zhang B, Zhang J, Zhang J., Free PMC Article | 09/24/2022 |
| Detection of recurrent colorectal cancer with high specificity using a reporting threshold for circulating tumor DNA methylated in BCAT1 and IKZF1. | Detection of recurrent colorectal cancer with high specificity using a reporting threshold for circulating tumor DNA methylated in BCAT1 and IKZF1.
Pedersen SK, Musher BL, LaPointe LC, Tuck MK, Symonds EL, Loayza N, Young GP. | 04/30/2022 |
| BCAT1: A risk factor in multiple cancers based on a pan-cancer analysis. | BCAT1: A risk factor in multiple cancers based on a pan-cancer analysis.
Li GS, Huang HQ, Liang Y, Pang QY, Sun HJ, Huang ZG, Dang YW, Yang LJ, Chen G., Free PMC Article | 04/23/2022 |
| A single nucleotide polymorphism in BCAT1 gene is associated with type 2 diabetes mellitus. | A single nucleotide polymorphism in BCAT1 gene is associated with type 2 diabetes mellitus.
Alfaqih MA, Abu-Khdair ZE, Khabour O, Kheirallah KA, Khanfar M. | 04/16/2022 |
| Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis. | Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis.
Mao L, Chen J, Lu X, Yang C, Ding Y, Wang M, Zhang Y, Tian Y, Li X, Fu Y, Yang Y, Gu Y, Gao F, Huang J, Liao L., Free PMC Article | 02/12/2022 |
| Variables Associated with Detection of Methylated BCAT1 or IKZF1 in Blood from Patients Without Colonoscopically Evident Colorectal Cancer. | Variables Associated with Detection of Methylated BCAT1 or IKZF1 in Blood from Patients Without Colonoscopically Evident Colorectal Cancer.
Saluja H, Young GP, Kholmurodova F, Symonds EL. | 01/15/2022 |
| Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC). | Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC).
Musher BL, Melson JE, Amato G, Chan D, Hill M, Khan I, Kochuparambil ST, Lyons SE, Orsini J Jr, Pedersen SK, Robb B, Saltzman J, Silinsky J, Gaur S, Tuck MK, LaPointe LC, Young GP. | 12/25/2021 |
| Differential expression of the BCAT isoforms between breast cancer subtypes. | Differential expression of the BCAT isoforms between breast cancer subtypes.
Shafei MA, Flemban A, Daly C, Kendrick P, White P, Dean S, Qualtrough D, Conway ME., Free PMC Article | 11/6/2021 |
| BCAT1 overexpression regulates proliferation and cMyc/GLUT1 signaling in head and neck squamous cell carcinoma. | BCAT1 overexpression regulates proliferation and c‑Myc/GLUT1 signaling in head and neck squamous cell carcinoma.
Wang H, Wang F, Ouyang W, Jiang X, Wang Y., Free PMC Article | 11/6/2021 |
| Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas. | Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas.
Yi L, Fan X, Li J, Yuan F, Zhao J, Nistér M, Yang X., Free PMC Article | 08/21/2021 |
| BCAT-induced autophagy regulates Abeta load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease. | BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease.
Harris M, El Hindy M, Usmari-Moraes M, Hudd F, Shafei M, Dong M, Hezwani M, Clark P, House M, Forshaw T, Kehoe P, Conway ME. | 08/7/2021 |
| BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages. | BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages.
Ko JH, Olona A, Papathanassiu AE, Buang N, Park KS, Costa ASH, Mauro C, Frezza C, Behmoaras J., Free PMC Article | 07/10/2021 |
| Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer. | Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer.
Song Y, Zhao B, Xu Y, Ren X, Lin Y, Zhou L, Sun Q., Free PMC Article | 02/27/2021 |
| Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours. | Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours.
Zhu Z, Achreja A, Meurs N, Animasahun O, Owen S, Mittal A, Parikh P, Lo TW, Franco-Barraza J, Shi J, Gunchick V, Sherman MH, Cukierman E, Pickering AM, Maitra A, Sahai V, Morgan MA, Nagrath S, Lawrence TS, Nagrath D., Free PMC Article | 01/2/2021 |
| Positive BCAT1 stain could be used to exclude diffuse gliomas with IDH1 codon 132 and IDH2 codon 172 mutations | Loss of BCAT1 Expression is a Sensitive Marker for IDH-Mutant Diffuse Glioma.
Chen YY, Ho HL, Lin SC, Hsu CY, Ho DM. | 03/28/2020 |
| Our study identifies BCAT1 as a novel methylome signature distinguishing spindle/desmoplastic melanoma from cutaneous malignant peripheral nerve sheath tumor. | BCAT1 and miR-2504: novel methylome signature distinguishes spindle/desmoplastic melanoma from superficial malignant peripheral nerve sheath tumor.
Jour G, Vasudevaraja V, Prieto VG, Snuderl M, Torres-Cabala CA, Al-Rohil R, Sulman EP, Ballester LY, Aung PP. | 12/28/2019 |