| The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls. | The CB(1) receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.
Costas-Insua C, Hermoso-López A, Moreno E, Montero-Fernández C, Álvaro-Blázquez A, Maroto IB, Sánchez-Ruiz A, Diez-Alarcia R, Blázquez C, Morales P, Canela EI, Casadó V, Urigüen L, Perea G, Bellocchio L, Rodríguez-Crespo I, Guzmán M., Free PMC Article | 04/27/2024 |
| Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase alpha1. | Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1.
Kang HJ, Lee KJ, Woo J, Kim J, Kim YK, Lee CH, Yoo CG, Lee KH., Free PMC Article | 03/26/2022 |
| Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1. | Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1.
Akber U, Jo H, Jeon S, Yang SJ, Bong S, Lim S, Kim YK, Park ZY, Park CS., Free PMC Article | 11/27/2021 |
| Gluconeogenic signals regulate hepcidin gene expression via a CRBN-KLF15 axis. | Gluconeogenic signals regulate hepcidin gene expression via a CRBN-KLF15 axis.
Jo JR, Lee SE, An S, Nedumaran B, Ghosh S, Park KG, Kim YD., Free PMC Article | 10/30/2021 |
| Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout. | Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout.
Jeon SJ, Ham J, Park CS, Lee B., Free PMC Article | 07/3/2021 |
| Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes. | Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes.
Hesterberg RS, Beatty MS, Han Y, Fernandez MR, Akuffo AA, Goodheart WE, Yang C, Chang S, Colin CM, Alontaga AY, McDaniel JM, Mailloux AW, Billington JMR, Yue L, Russell S, Gillies RJ, Yun SY, Ayaz M, Lawrence NJ, Lawrence HR, Yu XZ, Fu J, Darville LN, Koomen JM, Ren X, Messina J, Jiang K, Garrett TJ, Rajadhyaksha AM, Cleveland JL, Epling-Burnette PK., Free PMC Article | 03/20/2021 |
| CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. | CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.
Fu SJ, Hu MC, Peng YJ, Fang HY, Hsiao CT, Chen TY, Jeng CJ, Tang CY., Free PMC Article | 03/6/2021 |
| Crbn modulates calcium influx by regulating Orai1 during efferocytosis. | Crbn modulates calcium influx by regulating Orai1 during efferocytosis.
Moon H, Min C, Kim G, Kim D, Kim K, Lee SA, Moon B, Yang S, Lee J, Yang SJ, Cho SK, Lee G, Lee CS, Park CS, Park D., Free PMC Article | 11/21/2020 |
| Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity. | Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity.
Yang SJ, Jeon SJ, Van Nguyen T, Deshaies RJ, Park CS, Lee KM. | 10/31/2020 |
| CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF-kappaB signaling. | CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF-κB signaling.
Yang H, Song Z, Hong D. | 10/24/2020 |
| CRBN could protect cells from DNA damage-induced apoptosis, which provides a novel understanding of physiological roles of CRBN in p53-mediated apoptosis. | Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53.
Zhou L, Xu G., Free PMC Article | 04/11/2020 |
| Crbn KO animals showed cognitive deficits caused by enhanced BK channel activity and reduced presynaptic glutamate release. | Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel.
Choi TY, Lee SH, Kim YJ, Bae JR, Lee KM, Jo Y, Kim SJ, Lee AR, Choi S, Choi LM, Bang S, Song MR, Chung J, Lee KJ, Kim SH, Park CS, Choi SY., Free PMC Article | 10/5/2019 |
| We show that Crbn is robustly expressed in the mouse hippocampus and Crbn(KO) mice exhibit hyperphosphorylated levels of AMPKalpha | Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.
Bavley CC, Rice RC, Fischer DK, Fakira AK, Byrne M, Kosovsky M, Rizzo BK, Del Prete D, Alaedini A, Morón JA, Higgins JJ, D'Adamio L, Rajadhyaksha AM., Free PMC Article | 07/6/2019 |
| dBET1 stimulates CRBN's E3 ubiquitin-conjugating function and degrades BRD4 in both mouse and human cells. | Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, Yoder JA, Rajadhyaksha AM, Schönbrunn E, Lawrence HR, Lawrence NJ, Epling-Burnette PK., Free PMC Article | 01/12/2019 |
| Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner. | Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner.
Zhou L, Hao Z, Wang G, Xu G. | 01/12/2019 |
| Collectively, our data suggested that CRBN is a potential treatment option against diabetes-induced osteolytic bone disease. | Cereblon (CRBN) deletion reverses streptozotocin induced diabetic osteoporosis in mice.
Yao C, Guo X, Yao WX, Zhang C. | 02/24/2018 |
| Data show that cereblon (CRBN) limits CD4(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Kv1.3) expression. | Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation.
Kang JA, Park SH, Jeong SP, Han MH, Lee CR, Lee KM, Kim N, Song MR, Choi M, Ye M, Jung G, Lee WW, Eom SH, Park CS, Park SG., Free PMC Article | 02/10/2018 |
| CRBN negatively regulates TLR4 signaling via attenuation of TRAF6 and TAB2 ubiquitination. | Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6.
Min Y, Wi SM, Kang JA, Yang T, Park CS, Park SG, Chung S, Shim JH, Chun E, Lee KY., Free PMC Article | 09/30/2017 |
| CRBN is involved in the activation of PERK and the Ire1 pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK. | Depletion of the cereblon gene activates the unfolded protein response and protects cells from ER stress-induced cell death.
Lee KM, Yang SJ, Park S, Choi YD, Shin HK, Pak JH, Park CS, Kim I. | 05/9/2015 |
| results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients | Functional effects of a pathogenic mutation in Cereblon (CRBN) on the regulation of protein synthesis via the AMPK-mTOR cascade.
Lee KM, Yang SJ, Choi JH, Park CS., Free PMC Article | 12/20/2014 |
| Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice. | Ablation of cereblon attenuates myocardial ischemia-reperfusion injury.
Kim J, Lee KM, Park CS, Park WJ. | 08/16/2014 |
| findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning. | Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.
Rajadhyaksha AM, Ra S, Kishinevsky S, Lee AS, Romanienko P, DuBoff M, Yang C, Zupan B, Byrne M, Daruwalla ZR, Mark W, Kosofsky BE, Toth M, Higgins JJ., Free PMC Article | 03/31/2012 |
| CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK alpha1) and inhibits the activation of AMPK activation. | Functional modulation of AMP-activated protein kinase by cereblon.
Lee KM, Jo S, Kim H, Lee J, Park CS. | 04/23/2011 |
| These results imply that Nrf2 stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells. | Induction of cereblon by NF-E2-related factor 2 in neuroblastoma cells exposed to hypoxia-reoxygenation.
Lee KJ, Lee KM, Jo S, Kang KW, Park CS. | 10/23/2010 |