| Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury. | Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury.
Guo Q, Liu Q, Zhou S, Lin Y, Lv A, Zhang L, Li L, Huang F. | 11/7/2024 |
| Effects of Apelin on the fibrosis of retinal tissues and Muller cells in diabetes retinopathy through the JAK2/STAT3 signalling pathway. | Effects of Apelin on the fibrosis of retinal tissues and Müller cells in diabetes retinopathy through the JAK2/STAT3 signalling pathway.
Li Y, Hu Q, Wang B. | 01/3/2024 |
| Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition. | Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition.
Cardoso Dos Santos LM, Azar P, Brun C, König S, Roatti A, Baertschi AJ, Chaabane C, Bochaton-Piallat ML., Free PMC Article | 11/3/2023 |
| Apelin signalling in the periaqueductal grey matter alleviates capsaicin-evoked pulpal nocifensive behaviour and capsaicin-induced spatial learning and memory impairments in rat. | Apelin signalling in the periaqueductal grey matter alleviates capsaicin-evoked pulpal nocifensive behaviour and capsaicin-induced spatial learning and memory impairments in rat.
Soleimani AH, Dehghani A, Abbasnejad M, Esmaeili-Mahani S, Raoof M, Lobbezoo F. | 07/13/2023 |
| The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats. | The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats.
Gemici B, Birsen İ, İzgüt-Uysal VN. | 07/12/2023 |
| Feedback Interaction Between Apelin and Endoplasmic Reticulum Stress in the Rat Myocardium. | Feedback Interaction Between Apelin and Endoplasmic Reticulum Stress in the Rat Myocardium.
Jin S, Wang Y, Ma L, Zhang J, Huang P, Zhang H, Liu X, Wu Y, Wang X, Teng X. | 01/28/2023 |
| Possible roles of exercise and apelin against pregnancy complications. | Possible roles of exercise and apelin against pregnancy complications.
Alizadeh Pahlavani H., Free PMC Article | 10/1/2022 |
| Elevated reactivity of Apelin inhibited renal fibrosis induced by chronic intermittent hypoxia. | Elevated reactivity of Apelin inhibited renal fibrosis induced by chronic intermittent hypoxia.
Wang Y, Wang Y, Xue K, Gao F, Li C, Fang H. | 11/13/2021 |
| Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. | Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats.
Zhou S, Chen S, Xie W, Guo X, Zhao J. | 02/13/2021 |
| The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue. | The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue.
Akkan SS, İzgüt-Uysal VN, Çakır T, Özbey Ö, Üstünel İ. | 11/21/2020 |
| Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM. | Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM.
Wang Y, Zhang R, Shen H, Kong J, Lv X., Free PMC Article | 10/24/2020 |
| The enhanced activity of endogenous apelin and APJ receptor in paraventricular nucleus contributes to sympathetic activation in hypertension. | Superoxide anions modulate the performance of apelin in the paraventricular nucleus on sympathetic activity and blood pressure in spontaneously hypertensive rats.
Zhao Y, Li Y, Li Z, Xu B, Chen P, Yang X. | 07/4/2020 |
| Apelin-13 protects PC12 cells against methamphetamine-induced oxidative stress, autophagy, and apoptosis. | Apelin-13 Protects PC12 Cells Against Methamphetamine-Induced Oxidative Stress, Autophagy and Apoptosis.
Foroughi K, Khaksari M, Rahmati M, Bitaraf FS, Shayannia A. | 01/25/2020 |
| Apelin-13 reverses memory impairment and depression-like behavior in chronic stressed rats. | Apelin-13 reverses memory impairment and depression-like behavior in chronic social defeat stressed rats.
Tian SW, Xu F, Gui SJ. | 06/29/2019 |
| apelin-36 had a positive inotropic effect on the isolated rat heart and can induce eNOS, Serca2a and beta2-AR genes activation that enhances contractility of the heart | The impact of apelin-36 on isolated rat hearts as a member of apelin family.
Kutlay O. | 05/11/2019 |
| Results suggest that apelin-13 upregulates BDNF against chronic stress-induced depression-like phenotypes by ameliorating hypothalamus-pituitary-adrenal axis and hippocampal glucocorticoid receptor dysfunctions. | Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions.
Dai TT, Wang B, Xiao ZY, You Y, Tian SW. | 03/23/2019 |
| both apelin and arginine vasopressin reacted to osmotic stimuli in T2DM but with less sensitivity than in control rats; in spite of its abnormal increased levels in diabetic rats, apelin maintained its role through counteracting AVP action | Cross-talk between apelin and vasopressin in response to different osmotic stimuli in type 2 diabetic rats.
Dawood AF, Sabry MM, Estaphan SA, Mohamed EA, Younes SF, Rashed LA, Elzainy AW. | 03/16/2019 |
| Appropriate concentration of apelin may reduce retinal microglial cells in a rat model of oxygen-induced retinopathy of prematurity. | Effects of apelin on retinal microglial cells in a rat model of oxygen-induced retinopathy of prematurity.
Zhang W, Zhang DG, Liang X, Zhang WL, Ma JX. | 10/13/2018 |
| Study shows that apelin-13 significantly attenuates cognitive impairments in 6-OHDA-treated animals. The data support the pro-cognitive property of apelin-13 in 6-OHDA-induced cognitive deficit and provided a new pharmacological aspect of the neuropeptide apelin. | Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats.
Haghparast E, Esmaeili-Mahani S, Abbasnejad M, Sheibani V. | 09/8/2018 |
| apelin effects on dynamic mechanical characteristics of single ventricular cardiomyocytes | Load-dependent effects of apelin on murine cardiomyocytes.
Peyronnet R, Bollensdorff C, Capel RA, Rog-Zielinska EA, Woods CE, Charo DN, Lookin O, Fajardo G, Ho M, Quertermous T, Ashley EA, Kohl P., Free PMC Article | 04/14/2018 |
| The present study describes the role of spinal apelin in the processing of neuropathic pain induced by chronic constriction of the sciatic nerve, and elucidates receptor and intracellular mechanisms underlying apelin-mediated pain modulation. | Effect of the spinal apelin‑APJ system on the pathogenesis of chronic constriction injury‑induced neuropathic pain in rats.
Xiong Q, He W, Wang H, Zhou J, Zhang Y, He J, Yang C, Zhang B., Free PMC Article | 04/7/2018 |
| Apelin is an important regulator of aortic remodeling and adventitial fibrosis and a promising target for vasoprotective therapies. | Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling.
Xu R, Zhang ZZ, Chen LJ, Yu HM, Guo SJ, Xu YL, Oudit GY, Zhang Y, Chang Q, Song B, Chen DR, Zhu DL, Zhong JC. | 12/23/2017 |
| Apelin in 40 and 60mug/kg doses increased cardiac contractility, and reduced mean arterial pressure. | Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC.
Rostamzadeh F, Najafipour H, Yeganeh-Hajahmadi M, Esmaeili-Mahani S, Joukar S, Iranpour M. | 12/2/2017 |
| In type 2 diabetic rats, exercise improved body composition, skeletal muscle capillarization and increased plasma apelin levels. | Effects of exercise-induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats.
Son JS, Kim HJ, Son Y, Lee H, Chae SA, Seong JK, Song W. | 12/2/2017 |
| High fat diet causes significant increases in the expression of apelin and apelin receptor mRNA in the left ventricle. | The role of apelin in central cardiovascular regulation in rats with post-infarct heart failure maintained on a normal fat or high fat diet.
Czarzasta K, Cudnoch-Jedrzejewska A, Szczepanska-Sadowska E, Fus L, Puchalska L, Gondek A, Dobruch J, Gomolka R, Wrzesien R, Zera T, Gornicka B, Kuch M. | 09/16/2017 |