| Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring. | Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring.
Rouzer SK, Diaz MR., Free PMC Article | 10/22/2022 |
| CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia. | CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia.
Wang TY, Xia FY, Gong JW, Xu XK, Lv MC, Chatoo M, Shamsi BH, Zhang MC, Liu QR, Liu TX, Zhang DD, Lu XJ, Zhao Y, Du JZ, Chen XQ., Free PMC Article | 10/1/2022 |
| Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief. | Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief.
Mousa SA, Shaqura M, Khalefa BI, Li L, Al-Madol M, Treskatsch S, Schäfer M., Free PMC Article | 03/26/2022 |
| Activation of CRF1 receptors expressed in brainstem autonomic nuclei stimulates colonic enteric neurons and secreto-motor function in male rats. | Activation of CRF(1) receptors expressed in brainstem autonomic nuclei stimulates colonic enteric neurons and secreto-motor function in male rats.
Yuan PQ, Wu SV, Stengel A, Sato K, Taché Y. | 03/5/2022 |
| Ventromedial prefrontal cortex CRF1 receptors modulate the tachycardic activity of baroreflex. | Ventromedial prefrontal cortex CRF1 receptors modulate the tachycardic activity of baroreflex.
Brufatto JPT, Lagatta DC, Uliana DL, Firmino EMS, Borges-Assis AB, Resstel LBM. | 01/8/2022 |
| Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats. | Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats.
Zheng Y, Zhang YM, Tang ZS, Du JK, Guo DW, Xu YJ, Sheng H, Lu JQ, Ni X., Free PMC Article | 11/22/2021 |
| Social isolation of adolescent male rats increases anxiety and K(+) -induced dopamine release in the nucleus accumbens: Role of CRF-R1. | Social isolation of adolescent male rats increases anxiety and K(+) -induced dopamine release in the nucleus accumbens: Role of CRF-R1.
Novoa J, Rivero CJ, Pérez-Cardona EU, Freire-Arvelo JA, Zegers J, Yarur HE, Santiago-Marerro IG, Agosto-Rivera JL, González-Pérez JL, Gysling K, Segarra AC., Free PMC Article | 09/25/2021 |
| Sex differences in corticotropin releasing factor peptide regulation of inhibitory control and excitability in central amygdala corticotropin releasing factor receptor 1-neurons. | Sex differences in corticotropin releasing factor peptide regulation of inhibitory control and excitability in central amygdala corticotropin releasing factor receptor 1-neurons.
Agoglia AE, Tella J, Herman MA., Free PMC Article | 08/28/2021 |
| Results demonstrate that corticotropin-releasing factor excites the lateral vestibular nuclear (LVN) neurons by co-activation of both CRF receptors 1 and CRF receptors 2, suggesting that via the direct modulation on the LVN. | Corticotropin-releasing factor depolarizes rat lateral vestibular nuclear neurons through activation of CRF receptors 1 and 2.
Wang Y, Chen ZP, Yang ZQ, Zhang XY, Li JM, Wang JJ, Zhu JN. | 01/25/2020 |
| Stress-induced reinstatement, in a model of cocaine seeking relapse, is mediated by CRFR1-regulated dopaminergic projection from the ventral tegmental area to the prefrontal cortex. | Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking.
Vranjkovic O, Van Newenhizen EC, Nordness ME, Blacktop JM, Urbanik LA, Mathy JC, McReynolds JR, Miller AM, Doncheck EM, Kloehn TM, Stinnett GS, Gerndt CH, Ketchesin KD, Baker DA, Seasholtz AF, Mantsch JR., Free PMC Article | 10/12/2019 |
| Expression of OXTR became reduced following SPS in mPFC and amygdala, the latter exhibited higher therapeutic specificity to OXT. Expression of CRHR1 appeared more sensitive than CRHR2 to SPS, higher CRHR1 protein levels were found in mPFC and amygdala. | Effects of oxytocin on prosocial behavior and the associated profiles of oxytocinergic and corticotropin-releasing hormone receptors in a rodent model of posttraumatic stress disorder.
Wang SC, Lin CC, Tzeng NS, Tung CS, Liu YP., Free PMC Article | 08/3/2019 |
| Overexpression of Crhr1 in the central nucleus of the amygdala, results in increased responding to a stress-induced reinstatement task. | Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior.
Broccoli L, Uhrig S, von Jonquieres G, Schönig K, Bartsch D, Justice NJ, Spanagel R, Sommer WH, Klugmann M, Hansson AC., Free PMC Article | 02/23/2019 |
| Prenatal sGC exposure could program Crh and Crhr1 gene expression. | CRH/CRHR1 mediates prenatal synthetic glucocorticoid programming of depression-like behavior across 2 generations.
Xu YJ, Sheng H, Wu TW, Bao QY, Zheng Y, Zhang YM, Gong YX, Lu JQ, You ZD, Xia Y, Ni X. | 02/16/2019 |
| Irritability-like behavior following abstinence from ethanol exposure is partially mediated by activation of the CRF1 receptor. | CRF(1) Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure.
Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O., Free PMC Article | 06/16/2018 |
| CRHR1 blockade using Antalarmin (ANT) improved behavioral impairments, while conferring neuroprotection and blunting neuroinflammation in all hippocampal sub-regions post ischemia. Also observed reduced BDNF and TrkB mRNA and protein levels at the hippocampus, and increased expression at the hypothalamus and amygdala post ischemia, site-specific alterations which were regularized by pre-ischemic CRHR1 blockade. | CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery.
de la Tremblaye PB, Benoit SM, Schock S, Plamondon H. | 06/16/2018 |
| These results indicate that the central CRF signal, rather than the peripheral CRF signal would be related to anxiety and other behavioral changes, and CRF1 receptor antagonism in the central nervous system may be critical for identifying drug candidates for anxiety and mood disorders | Characterization of CRF(1) receptor antagonists with differential peripheral vs central actions in CRF challenge in rats.
Tanaka M, Tomimatsu Y, Sakimura K, Ootani Y, Sako Y, Kojima T, Aso K, Yano T, Hirai K. | 04/28/2018 |
| Study found that bilateral microinjection of selective CRF1 receptor antagonist CP376395 into the bed nucleus of stria terminalis (BNST) decreased the bradycardiac response to arterial pressure increase without affecting the baroreflex tachycardiac response; CRF2 receptor antagonist antisauvagine-30 microinjection reduced the tachycardiac response to arterial pressure decrease without affecting the reflex bradycardia. | CRF(1) and CRF(2) receptors in the bed nucleus of stria terminalis differently modulate the baroreflex function in unanesthetized rats.
Oliveira LA, Almeida J, Gomes-de-Souza L, Benini R, Crestani CC. | 04/14/2018 |
| the involvement of the HPA axis in traumainduced anxiety was demonstrated, and trauma-induced anxiety was attenuated by decreasing the hyperactivity of the HPA axis via miR34b by targeting CRHR1. | miR-34b attenuates trauma-induced anxiety-like behavior by targeting CRHR1.
Zhu J, Chen Z, Tian J, Meng Z, Ju M, Wu G, Tian Z., Free PMC Article | 03/17/2018 |
| Results suggest that corticotrophin-releasing factor type 1 receptor (CRF1) is involved in the modulation of the functions of the pituitary; moreover, protein expression and the distribution patterns of CRF1 are regulated by glucocorticoids in the rat anterior pituitary. | Distribution of Corticotrophin-Releasing Factor Type 1 Receptor-Like Immunoreactivity in the Rat Pituitary.
Mano-Otagiri A, Nemoto T, Yamauchi N, Kakinuma Y, Shibasaki T. | 01/6/2018 |
| These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation. | Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.
Ayyadurai S, Gibson AJ, D'Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ., Free PMC Article | 12/16/2017 |
| age-related alterations in acute central anorexigenic and hypermetabolic effects of CRF show different non-parallel patterns in males and females. Our findings underline the importance of gender differences. They also call the attention to the differential age-related changes in the CRF1 and CRF2 receptor systems | Acute central effects of corticotropin-releasing factor (CRF) on energy balance: Effects of age and gender.
Tenk J, Rostás I, Füredi N, Mikó A, Soós S, Solymár M, Gaszner B, Székely M, Pétervári E, Balaskó M. | 12/2/2017 |
| switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains | A switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains.
Narla C, Scidmore T, Jeong J, Everest M, Chidiac P, Poulter MO. | 11/26/2017 |
| Study identified the activation of CRFR1 in the basolateral amygdala as a key mechanism interfering with the effectiveness of immediate fear extinction training. | Involvement of CRFR(1) in the Basolateral Amygdala in the Immediate Fear Extinction Deficit.
Hollis F, Sevelinges Y, Grosse J, Zanoletti O, Sandi C., Free PMC Article | 11/4/2017 |
| The findings demonstrate that the long-term effect of acute stress on the expression of cocaine locomotor sensitization is partially mediated by CRFR1 in the ventromedial caudate putamen. | CRFR1 in the ventromedial caudate putamen modulates acute stress-enhanced expression of cocaine locomotor sensitization.
Liu S, Wang Z, Li Y, Sun X, Ge F, Yang M, Wang X, Wang N, Wang J, Cui C. | 09/9/2017 |
| Chronic noise significantly accelerated the progressive overproduction of corticosterone and upregulated CRF and CRFR1 mRNA and protein, both of which persisted 7-14days after noise exposure. | Effects of chronic noise on mRNA and protein expression of CRF family molecules and its relationship with p-tau in the rat prefrontal cortex.
Gai Z, Li K, Sun H, She X, Cui B, Wang R. | 04/22/2017 |