| The oncogenic role of LGR6 overexpression induced by aberrant Wnt/beta-catenin signaling in lung cancer. | The oncogenic role of LGR6 overexpression induced by aberrant Wnt/β-catenin signaling in lung cancer.
Sunaga N, Kaira K, Shimizu K, Tanaka I, Miura Y, Nakazawa S, Ohtaki Y, Kawabata-Iwakawa R, Sato M, Girard L, Minna JD, Hisada T., Free PMC Article | 01/16/2024 |
| DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study. | DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study.
Deng Y, Xu W, Ni M, Sun X, Wang X, Zhang T, Pan F. | 12/6/2023 |
| WNT enhancing signals in pancreatic cancer are transmitted by LGR6. | WNT enhancing signals in pancreatic cancer are transmitted by LGR6.
Wang J, Koch DT, Hofmann FO, Härtwig D, Beirith I, Janssen KP, Bazhin AV, Niess H, Werner J, Renz BW, Ilmer M., Free PMC Article | 11/7/2023 |
| Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases. | Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases.
Cortesi EE, Meeusen B, Vanstapel A, Verleden SE, Vanaudenaerde BM, Wuyts WA, Janssens W, Janssens V, Roskams T, Ventura JJ., Free PMC Article | 01/22/2022 |
| LGR6 activates the Wnt/beta-catenin signaling pathway and forms a beta-catenin/TCF7L2/LGR6 feedback loop in LGR6(high) cervical cancer stem cells. | LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6(high) cervical cancer stem cells.
Feng Q, Li S, Ma HM, Yang WT, Zheng PS., Free PMC Article | 01/1/2022 |
| [Expression and Significance of Leucine-rich Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with Acute Lymphoblastic Leukemia]. | [Expression and Significance of Leucine-rich Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with Acute Lymphoblastic Leukemia].
Li X, Wang WP, Zhou M, Xu XR, Gao JZ. | 09/25/2021 |
| LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma. | LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.
Chai T, Shen Z, Zhang Z, Chen S, Gao L, Zhang P, Lin W, Kang M, Lin J., Free PMC Article | 02/27/2021 |
| Epithelial stem cell marker LGR6 expression identifies a low-risk subgroup in human papillomavirus positive oropharyngeal squamous cell carcinoma. | Epithelial stem cell marker LGR6 expression identifies a low-risk subgroup in human papillomavirus positive oropharyngeal squamous cell carcinoma.
Jank BJ, Kadletz L, Dunkler D, Haas M, Schnoell J, Kenner L, Heiduschka G. | 02/20/2021 |
| WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer. | WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer.
Lee S, Jun J, Kim WJ, Tamayo P, Howell SB., Free PMC Article | 11/21/2020 |
| LGR6 has a role in stimulating maresin 1's key proresolving functions of phagocytes | Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.
Chiang N, Libreros S, Norris PC, de la Rosa X, Serhan CN., Free PMC Article | 06/27/2020 |
| The expression levels of LGR6 in colon adenoma and adenocarcinoma were significantly higher than those in normal colon epithelial tissues. Low LGR6 expression predicted a short overall survival in patients with colon adenocarcinoma. | G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma.
Wang W, Ding S, Zhang H, Li J, Zhan J, Zhang H. | 02/1/2020 |
| Inhibition of LGR6 promoted the osteogenic differentiation of bone marrow stromal cells in vitro. | Down-regulation of LGR6 promotes bone fracture recovery using bone marrow stromal cells.
Cui Y, Huang R, Wang Y, Zhu L, Zhang X. | 10/20/2018 |
| Lgr6 has a tumorpromoting role in the development of colorectal cancer. | Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer.
Wang F, Dai CQ, Zhang LR, Bing C, Qin J, Liu YF. | 09/29/2018 |
| Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance. | Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
Blaas L, Pucci F, Messal HA, Andersson AB, Josue Ruiz E, Gerling M, Douagi I, Spencer-Dene B, Musch A, Mitter R, Bhaw L, Stone R, Bornhorst D, Sesay AK, Jonkers J, Stamp G, Malanchi I, Toftgård R, Behrens A., Free PMC Article | 06/3/2017 |
| Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1, which is known to be the ligand for LGR6. | Generation and characterization of monoclonal antibodies against human LGR6.
Funahashi SI, Suzuki Y, Nakano K, Kawai S, Suzuki M. | 06/3/2017 |
| LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing | Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. | 03/22/2017 |
| Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration. | LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Gong X, Carmon KS, Lin Q, Thomas A, Yi J, Liu Q., Free PMC Article | 01/12/2013 |