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    RBP2 retinol binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 5948, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands.

    Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands.
    Silvaroli JA, Plau J, Adams CH, Banerjee S, Widjaja-Adhi MAK, Blaner WS, Golczak M., Free PMC Article

    08/7/2024
    [Effect of RBP2 gene silencing on proliferation, migration and invasion of ovarian epithelial cancer SKOV3/DDP cells and its mechanism].

    [Effect of RBP2 gene silencing on proliferation, migration and invasion of ovarian epithelial cancer SKOV3/DDP cells and its mechanism].
    Feng TF, Yao DM, Zheng R, Jiang DS, Zhang LL, Xing Q, Li L.

    02/26/2022
    molecular dynamics simulations for the uptake of retinol by CRBP 1 and 2

    Deciphering protein dynamics changes along the pathway of retinol uptake by cellular retinol-binding proteins 1 and 2.
    Menozzi I, Polverini E, Berni R.

    02/9/2019
    study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses

    Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation.
    Yu X, Chen H, Zuo C, Jin X, Yin Y, Wang H, Jin M, Ozato K, Xu S., Free PMC Article

    10/27/2018
    Domain-swapped dimers of RBP2 provides evidence for ordered folding intermediates.

    Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates.
    Assar Z, Nossoni Z, Wang W, Santos EM, Kramer K, McCornack C, Vasileiou C, Borhan B, Geiger JH., Free PMC Article

    10/7/2017
    The structure of retinal-bound human CRBPII and the structure of retinol-bound CRBPII with retinol fully occupying the binding pocket are reported.

    Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal.
    Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J., Free PMC Article

    08/15/2015
    With only nine point mutations, the hCRBPII mutants induced a systematic shift in the absorption profile of all-trans-retinal of more than 200 nanometers across the visible spectrum.

    Tuning the electronic absorption of protein-embedded all-trans-retinal.
    Wang W, Nossoni Z, Berbasova T, Watson CT, Yapici I, Lee KS, Vasileiou C, Geiger JH, Borhan B., Free PMC Article

    12/22/2012
    Data show that CRBPI and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal.

    Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.
    Kane MA, Bright FV, Napoli JL., Free PMC Article

    07/2/2011
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
    Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB.

    06/30/2010
    HNF-4alpha is an important transcriptional factor that regulates human CRBPII gene expression; possibility for a novel function of HNF-4alpha in the regulation of human intestinal vitamin A absorption and metabolism

    Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells.
    Yamaguchi N, Miyamoto S, Ogura Y, Goda T, Suruga K.

    01/21/2010
    We report here the X-ray structures of human apo and holo CRBP II solved at 1.2 A resolution and compare the two structures between them and with the structures of zebrafish and rat CRBP II.

    Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution.
    Tarter M, Capaldi S, Carrizo ME, Ambrosi E, Perduca M, Monaco HL.

    01/21/2010
    retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation.

    Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation.
    Zhang L, E X, Luker KE, Shao JS, Levin MS, Suh E, Li E.

    01/21/2010
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