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    RCVRN recoverin [ Homo sapiens (human) ]

    Gene ID: 5957, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Serum anti-recoverin antibodies is found in elderly patients with retinitis pigmentosa and cancer.

    Serum anti-recoverin antibodies is found in elderly patients with retinitis pigmentosa and cancer.
    Sato T, Nishiguchi KM, Fujita K, Miya F, Inoue T, Sasaki E, Asano T, Tsuda S, Shiga Y, Kunikata H, Nakazawa M, Nakazawa T.

    06/5/2021
    Recoverin (Rec) is a prototypical calcium sensor protein primarily expressed in the vertebrate retina. The binding of two Ca(2+) ions to the functional EF-hand motifs induces the extrusion of a myristoyl group that increases the affinity of Rec for the membrane and leads to the formation of a complex with rhodopsin kinase (GRK1).

    Effects of Membrane and Biological Target on the Structural and Allosteric Properties of Recoverin: A Computational Approach.
    Borsatto A, Marino V, Abrusci G, Lattanzi G, Dell'Orco D., Free PMC Article

    04/4/2020
    these data confirm the scaffolding function of several cluster-forming residues and point to their critical role in supporting physiological activity of recoverin

    Experimental Insight into the Structural and Functional Roles of the 'Black' and 'Gray' Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs.
    Permyakov SE, Vologzhannikova AS, Nemashkalova EL, Kazakov AS, Denesyuk AI, Denessiouk K, Baksheeva VE, Zamyatnin AA Jr, Zernii EY, Uversky VN, Permyakov EA., Free PMC Article

    09/14/2019
    High RCVRN expression is associated with renal tumors.

    The cancer-retina antigen recoverin as a potential biomarker for renal tumors.
    Golovastova MO, Tsoy LV, Bocharnikova AV, Korolev DO, Gancharova OS, Alekseeva EA, Kuznetsova EB, Savvateeva LV, Skorikova EE, Strelnikov VV, Varshavsky VA, Vinarov AZ, Nikolenko VN, Glybochko PV, Zernii EY, Zamyatnin AA Jr, Bazhin AV, Philippov PP.

    03/4/2017
    Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.

    Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.
    Kumar RP, Ranaghan MJ, Ganjei AY, Oprian DD., Free PMC Article

    04/16/2016
    C39D substitution reduces alpha-helical content, decreases thermal stability and suppresses membrane association.

    Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association.
    Permyakov SE, Zernii EY, Knyazeva EL, Denesyuk AI, Nazipova AA, Kolpakova TV, Zinchenko DV, Philippov PP, Permyakov EA, Senin II.

    06/30/2012
    Aberrant hypomethylation of the recoverin gene region, overlapping the promoter up-stream of the first exon and the first exon itself, is involved in the aberrant expression of recoverin in tumor cells.

    Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells.
    Bazhin AV, De Smet C, Golovastova MO, Schmidt J, Philippov PP.

    04/30/2011
    A GRK1 region close to its C-terminus also seemed to be the binding site for S-modulin/recoverin.

    Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.
    Torisawa A, Arinobu D, Tachibanaki S, Kawamura S.

    01/21/2010
    Human recoverin is expressed in SCLC cells cultured from an anti-recoverin antibody-negative patient with CAR. KK0206 might be important for further research on SCLC related retinopathy.

    Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy.
    Kobayashi M, Ikezoe T, Uemura Y, Takeuchi T, Ueno H, Ohtsuki Y, Taguchi H.

    01/21/2010
    recoverin has a pathological role in cancer-associated retinopathy

    Pathological roles of recoverin in cancer-associated retinopathy.
    Ohguro H, Nakazawa M.

    01/21/2010
    There are cis-acting elements in the 5' non-coding region of the recoverin gene that are involved in the activation and suppression of gene expression.

    Functional analysis of the human recoverin gene promoter.
    Wiechmann A, Howard E.

    01/21/2010
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