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    BCL2 BCL2 apoptosis regulator [ Homo sapiens (human) ]

    Gene ID: 596, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity.

    BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity.
    Westaby D, Jiménez-Vacas JM, Figueiredo I, Rekowski J, Pettinger C, Gurel B, Lundberg A, Bogdan D, Buroni L, Neeb A, Padilha A, Taylor J, Zeng W, Das S, Hobern E, Riisnaes R, Crespo M, Miranda S, Ferreira A, Hanratty BP, Nava Rodrigues D, Bertan C, Seed G, Fenor de La Maza MLD, Guo C, Carmichael J, Grochot R, Chandran K, Stavridi A, Varkaris A, Stylianou N, Hollier BG, Tunariu N, Balk SP, Carreira S, Yuan W, Nelson PS, Corey E, Haffner M, de Bono J, Sharp A., Free PMC Article

    11/12/2024
    ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway.

    ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway.
    Lin CY, Liang WC, Yu YC, Chang SC, Lai MC, Jong YJ., Free PMC Article

    10/31/2024
    Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.

    Toll-like receptor signaling in multiple myeloma cells promotes the expression of pro-survival genes B-cell lymphoma 2 and MYC and modulates the expression of B-cell maturation antigen.
    Tryggestad SS, Roseth IA, Aass KR, Ørning NEH, Mjelle R, Hella H, Standal T., Free PMC Article

    10/30/2024
    BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains.

    BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains.
    Beigl TB, Paul A, Fellmeth TP, Nguyen D, Barber L, Weller S, Schäfer B, Gillissen BF, Aulitzky WE, Kopp HG, Rehm M, Andrews DW, Pluhackova K, Essmann F., Free PMC Article

    09/18/2024
    Two recurrent types of IGH::5' BCL2 breakpoints representing cytogenetic ins(14;18)(q32;q21q21) and t(14;18)(q32;q21), mediated by the VDJ and class switch recombination processes, respectively.

    Two recurrent types of IGH::5' BCL2 breakpoints representing cytogenetic ins(14;18)(q32;q21q21) and t(14;18)(q32;q21), mediated by the VDJ and class switch recombination processes, respectively.
    Maekawa F, Hayashida M, Takeoka K, Fukutsuka K, Nakagawa M, Akasaka T, Sakamoto S, Sumiyoshi S, Kobashi Y, Ohno H.

    08/22/2024
    miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway.

    miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway.
    Li J, Feng R, Zhang X, Hou W, Zhang Y, Li J, Li X, Jian F, Zhang L, Zhang S, Wang R.

    08/19/2024
    Bcl-2 dependent modulation of Hippo pathway in cancer cells.

    Bcl-2 dependent modulation of Hippo pathway in cancer cells.
    D'Aguanno S, Brignone M, Scalera S, Chiacchiarini M, Di Martile M, Valentini E, De Nicola F, Ricci A, Pelle F, Botti C, Maugeri-Saccà M, Del Bufalo D., Free PMC Article

    08/15/2024
    Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.

    Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.
    Wise AR, Maloney S, Hering A, Zabala S, Richmond GE, VanKlompenberg MK, Nair MT, Prosperi JR., Free PMC Article

    07/5/2024
    Combinatorial Inhibition of Complement Factor D and BCL2 for Early-Onset Colorectal Cancer.

    Combinatorial Inhibition of Complement Factor D and BCL2 for Early-Onset Colorectal Cancer.
    Rahman S, Affleck AG 4th, Ruhl RA, Patel RK, Gao L, Brinkerhoff BT, Tsikitis VL, Anand S.

    06/27/2024
    HPV infection and its correlation with p53 and Bcl-2 among pregnant mothers and their infants.

    HPV infection and its correlation with p53 and Bcl-2 among pregnant mothers and their infants.
    Sen S.

    06/7/2024
    GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis.

    GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis.
    Dang T, Yu J, Yu Y, Jiang J, Shi Y, Yu S, Peng C, Min X, Xiong Y, Long P, Zhou W, Dai D., Free PMC Article

    06/6/2024
    Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in patients with Behcet's disease.

    Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in patients with Behçet's disease.
    Baskol G, Yetkin MÖ, Sevim DG, Guclu K, Arda H, Saracoglu H, Gahramanov K, Evereklioglu C., Free PMC Article

    05/7/2024
    Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder cancer recurrence.

    Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder cancer recurrence.
    Varchulova Novakova Z, Harsanyi S, Bevizova K, Kuniakova M, Schwarzova L, Trebaticky B, Danisovic L, Ziaran S.

    04/22/2024
    miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2.

    miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2.
    Wang S, Xie Y, Liu F, Wang J, Yang Y, Wang J, Wang Y, Hang X.

    04/5/2024
    Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement.

    Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement.
    Liphaus BL, Silva SC, Palmeira P, Silva CA, Goldenstein-Schainberg C, Carneiro-Sampaio M., Free PMC Article

    04/5/2024
    Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax.

    Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax.
    Li D, Yuan Y, Meng C, Lin Z, Zhao M, Shi L, Li M, Ye D, Cai Y, He X, Ye H, Zhou S, Zhou H, Gao S., Free PMC Article

    04/5/2024
    Impact of MYC and BCL2 double expression on outcomes in primary CNS lymphoma: a UK multicenter analysis.

    Impact of MYC and BCL2 double expression on outcomes in primary CNS lymphoma: a UK multicenter analysis.
    Poynton E, Chernucha E, Day J, Prodger C, Hopkins D, Rakesh P, O'Neill T, Thakrar N, Akarca A, Jamal E, Ali A, Kirkwood AA, Pomplun S, Marafioti T, Calaminici M, Greaves P, Chaganti S, McKay P, Smith J, Eyre TA, Martinez-Calle N, Cwynarski K, Fox CP, Okosun J., Free PMC Article

    04/2/2024
    Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.

    Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.
    Huang J, Jin S, Guo R, Wu W, Yang C, Qin Y, Chen Q, He X, Qu J, Yang Z.,

    03/20/2024
    Impact of BCL-2 Expression on Course of Disease in Neuroblastoma.

    Impact of BCL-2 Expression on Course of Disease in Neuroblastoma.
    Muehling J, Fröba-Pohl A, Muensterer OJ, von Schweinitz D, Kappler R.

    02/27/2024
    14-3-3-eta interacts with BCL-2 to protect human endothelial progenitor cells from ox-LDL-triggered damage.

    14-3-3-η interacts with BCL-2 to protect human endothelial progenitor cells from ox-LDL-triggered damage.
    Zhou H, Sun X, Dai Y, Wang X, Dai Z, Li X.

    02/16/2024
    Bcl-2 supports survival and metabolic fitness of quiescent tissue-resident ILC3.

    Bcl-2 supports survival and metabolic fitness of quiescent tissue-resident ILC3.
    King JI, Melo-Gonzalez F, Malengier-Devlies B, Tachó-Piñot R, Magalhaes MS, Hodge SH, Romero Ros X, Gentek R, Hepworth MR., Free PMC Article

    02/16/2024
    m6A-related lncRNAs as potential biomarkers and the lncRNA ELFN1-AS1/miR-182-5p/BCL-2 regulatory axis in diffuse large B-cell lymphoma.

    m6A-related lncRNAs as potential biomarkers and the lncRNA ELFN1-AS1/miR-182-5p/BCL-2 regulatory axis in diffuse large B-cell lymphoma.
    Yang Q, Lu Y, Du A., Free PMC Article

    02/8/2024
    Genetic variants in BCL-2 family genes influence the risk of non-syndromic cleft lip with or without cleft palate.

    Genetic variants in BCL-2 family genes influence the risk of non-syndromic cleft lip with or without cleft palate.
    Cui X, Zhu G, Han M, Li X, Lou S, Xing C, Xu S, Pan Y, Wang L.

    02/6/2024
    Value of Bax and Bcl2 expression in peripheral blood mononuclear cells for clinical prognosis of patients with chronic heart failure.

    Value of Bax and Bcl2 expression in peripheral blood mononuclear cells for clinical prognosis of patients with chronic heart failure.
    Chen Y, Li S, Yang Z, Wang T, Yin F, Zhao X, Zhang Y., Free PMC Article

    02/1/2024
    Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma.

    Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma.
    Auni Kamal D, Fisal Shakir Agha N, Housein Z., Free PMC Article

    01/31/2024
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