| Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of the RNASEL gene and risk factors in patients with prostate cancer in Burkina Faso. | Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of the RNASEL gene and risk factors in patients with prostate cancer in Burkina Faso.
Kadanga E, Zouré AA, Zohoncon TM, Traoré L, Ky BD, Yonli AT, Traoré DDA, Bazié BVJTE, Sombié HK, Sorgho PA, Tovo SFA, Traoré K, Ouedraogo TC, Djigma FW, Simpore J., Free PMC Article | 06/11/2022 |
| OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis. | OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
Boehmer DFR, Formisano S, de Oliveira Mann CC, Mueller SA, Kluge M, Metzger P, Rohlfs M, Hörth C, Kocheise L, Lichtenthaler SF, Hopfner KP, Endres S, Rothenfusser S, Friedel CC, Duewell P, Schnurr M, Koenig LM. | 03/12/2022 |
| Zika virus employs the host antiviral RNase L protein to support replication factory assembly. | Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Whelan JN, Parenti NA, Hatterschide J, Renner DM, Li Y, Reyes HM, Dong B, Perez ER, Silverman RH, Weiss SR., Free PMC Article | 12/11/2021 |
| ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections. | ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections.
Ramnani B, Manivannan P, Jaggernauth S, Malathi K., Free PMC Article | 08/14/2021 |
| Sunitinib inhibits RNase L by destabilizing its active dimer conformation. | Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Tang J, Wang Y, Zhou H, Ye Y, Talukdar M, Fu Z, Liu Z, Li J, Neculai D, Gao J, Huang H. | 02/27/2021 |
| RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules. | RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules.
Burke JM, Lester ET, Tauber D, Parker R., Free PMC Article | 10/24/2020 |
| Our data show that rs486907 was not associated with the risk of prostate cancer in any populations. Nevertheless, rs627928 was reported to promote the development of prostate cancer (T vs. G: OR=1.08, 95% CI=1.01-1.15; TT+TG vs. GG: OR=1.14, 95% CI=1.03-1.25) in allele and recessive models in overall populations. | Evidence from 40 Studies that 2 Common Single-Nucleotide Polymorphisms (SNPs) of RNASEL Gene Affect Prostate Cancer Susceptibility: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-Compliant Meta-Analysis.
Xia J, Sun R., Free PMC Article | 03/21/2020 |
| The dependence on expression of ZAP antiviral protein (ZAP), 2'-5'-oligoadenylate synthetase (OAS3) and 2-5A-dependent ribonuclease (RNAseL) for CpG/UpA-mediated attenuation and the variable and often low level expression of these pathway proteins in certain cell types. | The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides.
Odon V, Fros JJ, Goonawardane N, Dietrich I, Ibrahim A, Alshaikhahmed K, Nguyen D, Simmonds P., Free PMC Article | 12/14/2019 |
| Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. | Mitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production.
Yang Y, Xiong S, Cai B, Luo H, Dong E, Li Q, Ji G, Zhao C, Wen Y, Wei Y, Yang H., Free PMC Article | 11/10/2018 |
| Our study suggests that RNASEL:p.Glu265* may be a genetic modifier of risk for early-onset breast cancer predisposition in carriers of high-risk mutations. | Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?
Nguyen-Dumont T, Teo ZL, Hammet F, Roberge A, Mahmoodi M, Tsimiklis H, Park DJ, Pope BJ, Lonie A, Kapuscinski MK, Mahmood K, ABCFR, Goldgar DE, Giles GG, Winship I, Hopper JL, Southey MC., Free PMC Article | 08/25/2018 |
| Results reported in the present study suggest a sex-specific interaction between miR-146a and RNASEL genes in melanoma skin cancer susceptibility. | Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.
Sangalli A, Orlandi E, Poli A, Maurichi A, Santinami M, Nicolis M, Ferronato S, Malerba G, Rodolfo M, Gomez Lira M. | 04/28/2018 |
| These results demonstrate that ablation of RNase L activity promotes survival of ADAR1 deficient cells even in the presence of MDA5 and MAVS, suggesting that the RNase L system is the primary sensor pathway for endogenous dsRNA that leads to cell death. | Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line.
Li Y, Banerjee S, Goldstein SA, Dong B, Gaughan C, Rath S, Donovan J, Korennykh A, Silverman RH, Weiss SR., Free PMC Article | 01/13/2018 |
| Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. | Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.
Singaraja RR, Tietjen I, Hovingh GK, Franchini PL, Radomski C, Wong K, vanHeek M, Stylianou IM, Lin L, Wang L, Mitnaul L, Hubbard B, Winther M, Mattice M, Legendre A, Sherrington R, Kastelein JJ, Akinsanya K, Plump A, Hayden MR., Free PMC Article | 01/13/2018 |
| findings suggest that beside the RLR pathway, RNase L cleavage products can also activate the NLRP3-inflammasome pathway, which requires DHX33 (DExD/H-box helicase) and the mitochondrial adaptor protein MAVS. | RNase L and the NLRP3-inflammasome: An old merchant in a new trade.
Banerjee S. | 01/13/2018 |
| This study provides the evidence that germline variations in RNASEL are associated with fatal PCa in men (Gleason score >7 for rs486907 and RNASEL underexpressed [P = 0.007] in patients with PCa). | Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk.
Alvarez-Cubero MJ, Pascual-Geler M, Martinez-Gonzalez LJ, Expósito Ruiz M, Saiz M, Cozar JM, Lorente JA. | 01/6/2018 |
| By sequencing abundant RNA fragments generated by RNase L in cell lines, we identify site-specific cleavage of two groups of noncoding RNAs: Y-RNAs, whose function is poorly understood, and cytosolic tRNAs, which are essential for translation. | Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery.
Donovan J, Rath S, Kolet-Mandrikov D, Korennykh A., Free PMC Article | 10/28/2017 |
| RNASEL rs3738579 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients. | Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.
López-Rodríguez R, Hernández-Bartolomé Á, Borque MJ, Rodríguez-Muñoz Y, Martín-Vílchez S, García-Buey L, González-Moreno L, Real-Martínez Y, Muñoz de Rueda P, Salmerón J, Vidal-Castiñeira JR, López-Larrea C, Rodrigo L, Moreno-Otero R, Sanz-Cameno P., Free PMC Article | 10/7/2017 |
| Serum RNase-L levels were inversely associated with metabolic syndrome and age. | Human serum RNase-L level is inversely associated with metabolic syndrome and age.
Wang YT, Tseng PH, Chen CL, Han DS, Chi YC, Tseng FY, Yang WS., Free PMC Article | 10/7/2017 |
| We show that mutations in RNase L found in HPC patients may promote prostate cancer by increasing expression of AR-responsive genes and cell motility and identify novel roles of RNase L as a prostate cancer susceptibility gene. | RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.
Dayal S, Zhou J, Manivannan P, Siddiqui MA, Ahmad OF, Clark M, Awadia S, Garcia-Mata R, Shemshedini L, Malathi K., Free PMC Article | 04/22/2017 |
| Suggest that naturally occurring mutations in the RNase L gene might promote enhanced prostate cancer cell migration and metastasis. | RNase L is a negative regulator of cell migration.
Banerjee S, Li G, Li Y, Gaughan C, Baskar D, Parker Y, Lindner DJ, Weiss SR, Silverman RH., Free PMC Article | 11/5/2016 |
| This review outlines the role of RNase-L in antimicrobial immunity and the cytoskeleton-associated innate response. [review] | The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response.
Ezelle HJ, Malathi K, Hassel BA., Free PMC Article | 10/22/2016 |
| Data show that RNA decay by ribonuclease L (RNase L) has an important role in homeostasis and serves as a suppressor of cell adhesion. | Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.
Rath S, Donovan J, Whitney G, Chitrakar A, Wang W, Korennykh A., Free PMC Article | 08/20/2016 |
| Single Nucleotide Polymorphisms in RNASEL involved in the immune response are generally not associated with intraprostatic inflammation in men without a Prostate cancer diagnosis. | Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial.
Winchester DA, Gurel B, Till C, Goodman PJ, Tangen CM, Santella RM, Johnson-Pais TL, Leach RJ, Thompson IM, Xu J, Zheng SL, Lucia MS, Lippman SM, Parnes HL, Isaacs WB, Drake CG, De Marzo AM, Platz EA., Free PMC Article | 08/6/2016 |
| OAS3 displayed a higher affinity for dsRNA in intact cells than either OAS1 or OAS2, consistent with its dominant role in RNase L activation. | Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, Weiss SR., Free PMC Article | 07/30/2016 |
| Tanslation of vaccinia virus A27L and B5R genes is independent of PKR activation, but their expression is dependent on the RNase L activity. | Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity.
Fernández-Escobar M, Nájera JL, Baldanta S, Rodriguez D, Way M, Esteban M, Guerra S., Free PMC Article | 06/11/2016 |