| Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer. | Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer.
Liu T, Guo W, Luo K, Li L, Dong J, Liu M, Shi X, Wang Z, Zhang J, Yin J, Qiu N, Lu M, Chen D, Jia X, Liu H, Gu Y, Xiong Y, Zheng G, Xu G, He Z, Zhang Z., Free PMC Article | 07/30/2022 |
| ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m(6)A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype. | ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m(6)A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype.
Yu T, Yao L, Yin H, Teng Y, Hong M, Wu Q., Free PMC Article | 04/23/2022 |
| Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites. | Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites.
Paul A, Annunziato S, Lu B, Sun T, Evrova O, Planas-Paz L, Orsini V, Terracciano LM, Charlat O, Loureiro ZY, Ji L, Zamponi R, Sigoillot F, Lei H, Lindeman A, Russ C, Reece-Hoyes JS, Nicholson TB, Tchorz JS, Cong F., Free PMC Article | 03/5/2022 |
| RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. | RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.
Yang H, Hu J, Chen J, Chen Z, Jiao F, Cui J, Quan M, Wang L. | 12/12/2020 |
| BCL-2 is a new regulator of MST pathway. First, protein levels of MST2 and SAV1 were reduced significantly by co-expression of BCL-2. Physical interaction of BCL-2 with SAV1 was correlated with proteasomal degradation of SAV1 and MST2 proteins. | Mammalian Hippo kinase pathway is downregulated by BCL-2 via protein degradation.
Won GW, Park SH, Park J, Lee Y, Lee YH. | 02/15/2020 |
| Authors report that SAV1, a Hippo signaling component, inhibits Akt, a function independent of its role in Hippo signaling. Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt's movement to plasma membrane. Authors further identify cancer-associated SAV1 mutations with impaired ability to bind Akt, leading to Akt hyperactivation. | MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, Kim WY, Earp HS, Liu P., Free PMC Article | 05/4/2019 |
| SAV1 suppresses tumor growth in colorectal cancer and is regulated by miR-21. | SAV1, regulated by microRNA-21, suppresses tumor growth in colorectal cancer.
Jiang J, Chang W, Fu Y, Gao Y, Zhao C, Zhang X, Zhang S. | 04/20/2019 |
| These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points in the Hippo pathway. | Salvador has an extended SARAH domain that mediates binding to Hippo kinase.
Cairns L, Tran T, Fowl BH, Patterson A, Kim YJ, Bothner B, Kavran JM., Free PMC Article | 12/22/2018 |
| Here, the authors discover SAV1-mediated inhibition of the PP2A complex STRIPAK(SLMAP) as a key mechanism of MST1/2 activation. | SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Bae SJ, Ni L, Osinski A, Tomchick DR, Brautigam CA, Luo X., Free PMC Article | 06/23/2018 |
| WW45 has suppressive roles in lung cancer through a pathway involving Hedgehog/Gli1 signaling. | WW45, a Gli1 binding protein, negatively regulated Hedgehog signaling in lung cancer.
Li X, Zhou X, Fan Y, Zhang Y, Zu L, Yao F, Zhou Q., Free PMC Article | 03/24/2018 |
| SAV1 represses the activation of the Akt-mTOR signalling, and rapamycin treatment blunts the effects of SAV1 on in vitro and in vivo growth of colorectal cancer cells. | SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner.
Jiang J, Chang W, Fu Y, Gao Y, Zhao C, Zhang X, Zhang S., Free PMC Article | 09/2/2017 |
| using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 refolded under acidic pH. | Low pH-driven folding of WW45-SARAH domain leads to stabilization of the WW45-Mst2 complex.
Song J, Hong HR, Yamashita E, Park IY, Lee SJ. | 06/28/2016 |
| MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes. | The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis.
Kim M, Kim M, Lee MS, Kim CH, Lim DS. | 01/16/2016 |
| Mst2 and the Ser-3 residue of human WW45 function independently of each other in the regulation of the stability of human WW45. | A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation.
Wu D, Wu S. | 06/15/2013 |
| We also confirmed the interaction of HAX-1 and hSav1 in mammalian cells. | Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system.
Li X, Luo X, Li Z, Wang G, Xiao H, Tao D, Gong J, Hu J. | 11/17/2012 |
| downregulation of SAV1 and the consequent YAP1 activation are involved in the pathogenesis of high-grade clear cell renal cell carcinoma. | Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.
Matsuura K, Nakada C, Mashio M, Narimatsu T, Yoshimoto T, Tanigawa M, Tsukamoto Y, Hijiya N, Takeuchi I, Nomura T, Sato F, Mimata H, Seto M, Moriyama M., Free PMC Article | 04/21/2012 |
| MST and hSAV act as novel co-regulators of ERalpha and may play an important role in breast cancer pathogenesis. | Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand.
Park Y, Park J, Lee Y, Lim W, Oh BC, Shin C, Kim W, Lee Y. | 12/17/2011 |
| hSav1 interacts with HAX1 and attenuates its protective role against apoptosis in MCF-7 breast cancer cells. | hSav1 interacts with HAX1 and attenuates its anti-apoptotic effects in MCF-7 breast cancer cells.
Luo X, Li Z, Li X, Wang G, Liu W, Dong S, Cai S, Tao D, Yan Q, Wang J, Leng Y, Gong J, Hu J. | 11/5/2011 |
| a role for Salvador as a human tumor suppressor and RASSF1A effector and show that Salvador allows RASSF1A to modulate p73 independently of the hippo pathway. | Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions.
Donninger H, Allen N, Henson A, Pogue J, Williams A, Gordon L, Kassler S, Dunwell T, Latif F, Clark GJ., Free PMC Article | 07/30/2011 |
| Study reports that two Hippo pathway components, Mst2 and the scaffold protein hSav1, directly interact with Nek2A and regulate its ability to localize to centrosomes, and phosphorylate C-Nap1 and rootletin. | Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.
Mardin BR, Lange C, Baxter JE, Hardy T, Scholz SR, Fry AM, Schiebel E., Free PMC Article | 01/8/2011 |
| hSav1 is a newly identified protein that interacts with Mst1 and augments Mst1-mediated apoptosis. | [Overexpression of hSav1 promotes Mst1-induced apoptosis in HeLa cells].
Li ZM, Liu WC, Dong S, Luo XL, Li XL, Tao DD, Gong JP, Hu JB. | 10/23/2010 |
| hWW45 is required to enhance MST1-mediated apoptosis in vivo and thus is a critical player in an MST1-driven cell death signaling pathway. | The human WW45 protein enhances MST1-mediated apoptosis in vivo.
Luo X, Li Z, Yan Q, Li X, Tao D, Wang J, Leng Y, Gardner K, Judge SI, Li QQ, Hu J, Gong J., Free PMC Article | 01/21/2010 |
| Together these results show that hSav can bind to, and be phosphorylated by, Mst, and that the stabilizing effect of Mst on hSav requires its interaction with hSav but is probably not due to phosphorylation of hSav by Mst. | Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
Callus BA, Verhagen AM, Vaux DL. | 01/21/2010 |
| Salvador gene is not frequently mutated in human carcinoma tissues. | Mutational analysis of salvador gene in human carcinomas.
Yoo NJ, Soung YH, Lee JW, Park WS, Kim SY, Nam SW, Han JH, Kim SH, Lee JY, Lee SH. | 01/21/2010 |