| Myeloid GSK3alpha Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression. | Myeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.
Patel S, Shah N, D'Mello B, Lee A, Werstuck GH., Free PMC Article | 11/5/2024 |
| Differential role of bovine serum albumin and HCO3- in the regulation of GSK3 alpha during mouse sperm capacitation. | Differential role of bovine serum albumin and HCO3- in the regulation of GSK3 alpha during mouse sperm capacitation.
Mohanty G, Sanchez-Cardenas C, Paudel B, Tourzani DA, Salicioni AM, Santi CM, Gervasi MG, Pilsner JR, Darszon A, Visconti PE., | 03/13/2024 |
| Inhibition of mitochondrial cyclophilin D, a downstream target of glycogen synthase kinase 3alpha, improves sperm motility. | Inhibition of mitochondrial cyclophilin D, a downstream target of glycogen synthase kinase 3α, improves sperm motility.
Park SH, Gye MC., Free PMC Article | 02/12/2024 |
| GSK-3alpha aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion. | GSK-3α aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion.
Ahmad F, Marzook H, Gupta A, Aref A, Patil K, Khan AA, Saleh MA, Koch WJ, Woodgett JR, Qaisar R. | 11/22/2023 |
| Investigating the Role of Endothelial Glycogen Synthase Kinase3alpha/beta in Atherogenesis in Low Density Lipoprotein Receptor Knockout Mice. | Investigating the Role of Endothelial Glycogen Synthase Kinase3α/β in Atherogenesis in Low Density Lipoprotein Receptor Knockout Mice.
Mastrogiacomo L, Werstuck GH., Free PMC Article | 12/31/2022 |
| GSK3alpha phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells. | GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.
Laiman J, Hsu YJ, Loh J, Tang WC, Chuang MC, Liu HK, Yang WS, Chen BC, Chuang LM, Chang YC, Liu YW., Free PMC Article | 12/3/2022 |
| Fibroblast GSK-3alpha Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart. | Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart.
Umbarkar P, Tousif S, Singh AP, Anderson JC, Zhang Q, Tallquist MD, Woodgett J, Lal H., Free PMC Article | 10/1/2022 |
| Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3alpha Promotes Atherosclerotic Regression in Ldlr(-/-) Mice. | Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in Ldlr(-/-) Mice.
Patel S, Mastrogiacomo L, Fulmer M, Shi Y, Werstuck GH., Free PMC Article | 09/3/2022 |
| GSK3beta Exacerbates Myocardial Ischemia/Reperfusion Injury by Inhibiting Myc. | GSK3β Exacerbates Myocardial Ischemia/Reperfusion Injury by Inhibiting Myc.
Wen C, Lan M, Tan X, Wang X, Zheng Z, Lv M, Zhao X, Luo H, Liu Y, Wei P, Yue R, Hu H, Guo L., Free PMC Article | 05/14/2022 |
| Opposing Roles of GSK3alpha and GSK3beta Phosphorylation in Platelet Function and Thrombosis. | Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.
Moore SF, Agbani EO, Wersäll A, Poole AW, Williams CM, Zhao X, Li Y, Hutchinson JL, Hunter RW, Hers I., Free PMC Article | 11/13/2021 |
| Characterizing the Role of Glycogen Synthase Kinase-3alpha/beta in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways in Cultured Ldlr(-/-) Macrophages. | Characterizing the Role of Glycogen Synthase Kinase-3α/β in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways in Cultured Ldlr(-/-) Macrophages.
Patel S, Werstuck G., Free PMC Article | 10/30/2021 |
| Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced Retinal Ganglion Cells3. | Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced Retinal Ganglion Cells3.
Kisseleff E, Vigouroux RJ, Hottin C, Lourdel S, Thomas L, Shah P, Chédotal A, Perron M, Swaroop A, Roger JE., Free PMC Article | 10/23/2021 |
| GSK3beta inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia. | GSK3β inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia.
Nakao K, Singh M, Sapkota K, Hagler BC, Hunter RN, Raman C, Hablitz JJ, Nakazawa K., Free PMC Article | 08/7/2021 |
| Phosphoproteomics and Bioinformatics Analyses Reveal Key Roles of GSK-3 and AKAP4 in Mouse Sperm Capacitation. | Phosphoproteomics and Bioinformatics Analyses Reveal Key Roles of GSK-3 and AKAP4 in Mouse Sperm Capacitation.
Syifa N, Yang JT, Wu CS, Lin MH, Wu WL, Lai CW, Ku SH, Liang SY, Hung YC, Chou CT, Wang CS, Ishihama Y, Liao JH, Wu SH, Wu TH., Free PMC Article | 02/27/2021 |
| These results suggest that GSK-3alpha acts as a fatty acids sensor in cardiomyocytes, stimulating lipid uptake and promoting its accumulation in cardiomyocytes through biased activation of PPARalpha, and that this process underlies the development of lipotoxic cardiomyopathy in obesity and diabetes. | Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy.
Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J., Free PMC Article | 07/18/2020 |
| Interrelated functions of GSK3alpha and sperm PP2B are essential during epididymal sperm maturation and during fertilization. | Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs.
Dey S, Eisa A, Kline D, Wagner FF, Abeysirigunawardena S, Vijayaraghavan S., Free PMC Article | 07/11/2020 |
| Cardiomyocyte-GSK-3alpha promotes mPTP opening and heart failure in mice with chronic pressure overload. | Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload.
Ahmad F, Singh AP, Tomar D, Rahmani M, Zhang Q, Woodgett JR, Tilley DG, Lal H, Force T., Free PMC Article | 06/20/2020 |
| Lentiviral shRNA knockdown of GSK3b, but not GSK3b, in the medial prefrontal cortex (mPFC) of WT mice also impaired Novel object recognition. CONCLUSION: These findings suggest that D3R acts via GSK3b signaling in the mPFC to play a functional role in Novel object recognition memory | Dopamine D(3) receptor and GSK3β signaling mediate deficits in novel object recognition memory within dopamine transporter knockdown mice.
Chang PK, Chu J, Tsai YT, Lai YH, Chen JC., Free PMC Article | 06/6/2020 |
| cAMP, PKA, and GSK3 are interrelated in regulation of sperm function. | Cyclic AMP and glycogen synthase kinase 3 form a regulatory loop in spermatozoa.
Dey S, Goswami S, Eisa A, Bhattacharjee R, Brothag C, Kline D, Vijayaraghavan S., Free PMC Article | 10/5/2019 |
| Testis and sperm are unique in their specific requirement of GSK3alpha for normal function and male fertility. | Isoform-specific requirement for GSK3α in sperm for male fertility.
Bhattacharjee R, Goswami S, Dey S, Gangoda M, Brothag C, Eisa A, Woodgett J, Phiel C, Kline D, Vijayaraghavan S., Free PMC Article | 10/5/2019 |
| our data describe GSK3 as a novel negative regulator of beta-adrenergic signaling in brown adipocytes. | GSK3 is a negative regulator of the thermogenic program in brown adipocytes.
Markussen LK, Winther S, Wicksteed B, Hansen JB., Free PMC Article | 09/14/2019 |
| Findings using a mouse model with genetic deletion of Akt3 demonstrate that the specific isoform Akt3 throughout the Akt3/GSK-3 pathway is involved during motor learning. | Motor learning deficits and striatal GSK-3 hyperactivity in Akt3 knockout mice.
Ouimet B, Pépin É, Bergeron Y, Chagniel L, Beaulieu JM, Massicotte G, Cyr M. | 03/23/2019 |
| GSK-3 plays a significant role in astrocyte development and behavioral control in mice. | Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice.
Jung EM, Ka M, Kim WY., Free PMC Article | 12/23/2017 |
| Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a phosphorylate splicing factors (Rbm8a, Srsf9, and Psf) and nucleolar proteins (Npm1 and Phf6); Gsk3b/Gsk3a are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3; Rbm8a = RNA binding motif protein 8a; Srsf9 = splicing factor, arginine-serine-rich 9; Psf = replication protein Psf; Npm1 = nucleophosmin 1; Phf6 = PHD finger protein 6) | Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.
Shinde MY, Sidoli S, Kulej K, Mallory MJ, Radens CM, Reicherter AL, Myers RL, Barash Y, Lynch KW, Garcia BA, Klein PS., Free PMC Article | 11/25/2017 |
| GSK3 is regulated through mechanisms independent of N-terminal serine phosphorylation in order for beta-catenin to be stabilized. | Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine.
Hey F, Giblett S, Forrest S, Herbert C, Pritchard C., Free PMC Article | 07/22/2017 |