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    ROCK1 Rho associated coiled-coil containing protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 6093, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.

    Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
    Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, Dai J, He D, Fan S, Wang Q.

    10/25/2024
    TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis.

    TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis.
    Hu F, Zhao L, Wang J, Li X, Xue Z, Ma Y, Zheng M, Chen C, Tong M, Guo X, Li H, Jin H, Xie Q, Zhang X, Huang C, Huang H.

    10/25/2024
    MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2/STAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells.

    MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2/STAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells.
    Wang J, Du A, Wang H, Li Y.

    07/26/2024
    ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.

    ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.
    Maas-Bauer K, Stell AV, Yan KL, de Vega E, Vinnakota JM, Unger S, Núñez N, Norona J, Talvard-Balland N, Koßmann S, Schwan C, Miething C, Martens US, Shoumariyeh K, Nestor RP, Duquesne S, Hanke K, Rackiewicz M, Hu Z, El Khawanky N, Taromi S, Andrlova H, Faraidun H, Walter S, Pfeifer D, Follo M, Waldschmidt J, Melchinger W, Rassner M, Wehr C, Schmitt-Graeff A, Halbach S, Liao J, Häcker G, Brummer T, Dengjel J, Andrieux G, Grosse R, Tugues S, Blazar BR, Becher B, Boerries M, Zeiser R., Free PMC Article

    06/24/2024
    LINC00645 inhibits renal cell carcinoma progression by interacting with HNRNPA2B1 to regulate the ROCK1 mRNA stability.

    LINC00645 inhibits renal cell carcinoma progression by interacting with HNRNPA2B1 to regulate the ROCK1 mRNA stability.
    Li H, Han X, Song L, Li X, Zhang L, Jin Z, Zhang Y, Wang T, Huang Z, Jia Z, Yang J.

    04/18/2024
    LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway.

    LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway.
    Qin X, Zeng B, Sooranna SR, Li M., Free PMC Article

    02/16/2024
    Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.

    Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
    Zhang Y, Li N, Kobayashi S., Free PMC Article

    02/12/2024
    Identification of ROCK1 as a novel biomarker for postmenopausal osteoporosis and pan-cancer analysis.

    Identification of ROCK1 as a novel biomarker for postmenopausal osteoporosis and pan-cancer analysis.
    Lai B, Jiang H, Gao Y, Zhou X., Free PMC Article

    09/25/2023
    lncRNA NEAT1 mediates LPS-induced pyroptosis of BEAS-2B cells via targeting miR-26a-5p/ROCK1 axis.

    lncRNA NEAT1 mediates LPS-induced pyroptosis of BEAS-2B cells via targeting miR-26a-5p/ROCK1 axis.
    Fan XY, Ma ZX, Tang LB, Shen HZ, Qi F, Xia JW.

    07/20/2023
    Negative pressure induces dedifferentiation of hepatocytes via RhoA/ROCK pathway.

    Negative pressure induces dedifferentiation of hepatocytes via RhoA/ROCK pathway.
    Khalifa MO, Moriwaki T, Zhang S, Zhou W, Ito K, Li TS.

    06/15/2023
    LINC00536 Promotes Breast Cancer Progression by Regulating ROCK1 via Sponging of miR-214-5p.

    LINC00536 Promotes Breast Cancer Progression by Regulating ROCK1 via Sponging of miR-214-5p.
    Hu C, Zhang X, Fang K, Guo Z, Li L.

    05/30/2023
    Tumor-suppressing effects of miR-381-3p in pediatric acute myeloid leukemia via ROCK1 downregulation.

    Tumor-suppressing effects of miR-381-3p in pediatric acute myeloid leukemia via ROCK1 downregulation.
    Ye Q, Ying Q, Dai Q, Liao C, Xiao G.

    01/28/2023
    LncRNA CCHE1 Participates in the Postoperative Distant Recurrence of Urothelial Bladder Cancer Possibly by Regulating ROCK1 Expression.

    LncRNA CCHE1 Participates in the Postoperative Distant Recurrence of Urothelial Bladder Cancer Possibly by Regulating ROCK1 Expression.
    Xie R, Chen X, Zhou J, Huang L, Jiang W.

    09/3/2022
    Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.

    Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.
    Wang J, Zhou L, Chen B, Yu Z, Zhang J, Zhang Z, Hu C, Bai Y, Ruan X, Wang S, Ouyang J, Wu A, Zhao X., Free PMC Article

    07/2/2022
    Evaluation of the rs35996865 polymorphism of the ROCK1 gene in sepsis.

    Evaluation of the rs35996865 polymorphism of the ROCK1 gene in sepsis.
    Kale A, Şener EF, Günay NE, Tahtasakal R, Demiryürek S, Günay N, Demiryürek AT.

    05/28/2022
    ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners.

    ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners.
    Ida Y, Umetsu A, Furuhashi M, Watanabe M, Tsugeno Y, Suzuki S, Hikage F, Ohguro H., Free PMC Article

    05/14/2022
    Rosuvastatin reduces expression of tissue factor through inhibiting RhoA/ROCK pathway to ameliorate atherosclerosis.

    Rosuvastatin reduces expression of tissue factor through inhibiting RhoA/ROCK pathway to ameliorate atherosclerosis.
    Zhou J, Yin G, Yu T, Zhang Y, Tian X, Xia D, Shi L.

    03/26/2022
    RhoA, ROCK-1, and ROCK-2 Gene Expression and Polymorphisms in Cholesteatoma Patients.

    RhoA, ROCK-1, and ROCK-2 Gene Expression and Polymorphisms in Cholesteatoma Patients.
    Görür K, Büyükafşar K, Akbaş E, İsmi O, Yolal Ertural D, Çetinkaya A., Free PMC Article

    02/26/2022
    ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.

    ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.
    Esposito D, Pant I, Shen Y, Qiao RF, Yang X, Bai Y, Jin J, Poulikakos PI, Aaronson SA., Free PMC Article

    02/26/2022
    R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

    R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
    Weber SM, Brossier NM, Prechtl A, Barnes S, Wilson LS, Brosius SN, Longo JF, Carroll SL., Free PMC Article

    02/26/2022
    Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.

    Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.
    Feng N, Guo Z, Wu X, Tian Y, Li Y, Geng Y, Yu Y., Free PMC Article

    02/12/2022
    MiR196a-5p in extracellular vesicles released from human nasopharyngeal carcinoma enhance the phagocytosis and secretion of microglia by targeting ROCK1.

    MiR196a-5p in extracellular vesicles released from human nasopharyngeal carcinoma enhance the phagocytosis and secretion of microglia by targeting ROCK1.
    Chen P, Liu R, Yu Z, Cui G, Zong W, Wang M, Xie M, Qu W, Wang W, Luo X.

    02/12/2022
    LncRNA RP11-390F4.3 inhibits invasion and migration of glioblastoma cells by downregulating ROCK1.

    LncRNA RP11-390F4.3 inhibits invasion and migration of glioblastoma cells by downregulating ROCK1.
    Fang Z, Weng Y, Xiao F, Yu J.

    01/29/2022
    Activation of TMEM16A Ca(2+)-activated Cl(-) channels by ROCK1/moesin promotes breast cancer metastasis.

    Activation of TMEM16A Ca(2+)-activated Cl(-) channels by ROCK1/moesin promotes breast cancer metastasis.
    Luo S, Wang H, Bai L, Chen Y, Chen S, Gao K, Wang H, Wu S, Song H, Ma K, Liu M, Yao F, Fang Y, Xiao Q., Free PMC Article

    01/22/2022
    MicroRNA5023p promotes Mycobacterium tuberculosis survival in macrophages by modulating the inflammatory response by targeting ROCK1.

    MicroRNA‑502‑3p promotes Mycobacterium tuberculosis survival in macrophages by modulating the inflammatory response by targeting ROCK1.
    Liu F, Dong Z, Lin Y, Yang H, Wang P, Zhang Y., Free PMC Article

    01/22/2022
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