| Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning. | Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning.
Mao X, Li Y, Zhong Y, Chen R, Wang K, Huang D, Luo X. | 12/21/2023 |
| Downregulation of Kruppel-like factor 14 accelerated cellular senescence and aging. | Downregulation of Krüppel-like factor 14 accelerated cellular senescence and aging.
Hou Y, Song Q, Wang Y, Liu J, Cui Y, Zhang X, Zhang J, Fu J, Cao M, Zhang C, Liu C, Wang X, Duan H, Wang P., Free PMC Article | 10/28/2023 |
| Hepatic Kruppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice. | Hepatic Krüppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice.
Chen X, Shi W, Xie Y, Wang Y, Yao Q, Ke H, Xu X, Liu H, Liu P, Zhou X. | 07/5/2023 |
| Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARalpha-mediated fatty acid oxidation. | Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation.
Chen L, Sha ML, Chen FT, Jiang CY, Li D, Xu CL, Pan DS, Xu ZJ, Tang QL, Xia SJ, Sun LH, Fan GJ, Shao Y. | 01/21/2023 |
| The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice. | The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
Liu L, Yuan Y, Zhou Y, Yao L, Li J, Chen F. | 12/3/2022 |
| The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis. | The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis.
Yuan Y, Fan G, Liu Y, Liu L, Zhang T, Liu P, Tu Q, Zhang X, Luo S, Yao L, Chen F, Li J., Free PMC Article | 04/16/2022 |
| Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism. | Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism.
Yang Q, Hinkle J, Reed JN, Aherrahrou R, Xu Z, Harris TE, Stephenson EJ, Musunuru K, Keller SR, Civelek M., Free PMC Article | 04/9/2022 |
| Kruppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development. | Krüppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development.
Wang H, Guo Y, Lu H, Luo Y, Hu W, Liang W, Garcia-Barrio MT, Chang L, Schwendeman A, Zhang J, Chen YE., Free PMC Article | 03/5/2022 |
| Klf14 is an imprinted transcription factor that regulates placental growth. | Klf14 is an imprinted transcription factor that regulates placental growth.
Koppes E, Shaffer B, Sadovsky E, Himes K, Barak Y, Sadovsky Y, Chaillet JR., Free PMC Article | 08/29/2020 |
| Kruppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo. | Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.
Xie W, Li L, Gong D, Zhang M, Lv YC, Guo DM, Zhao ZW, Zheng XL, Zhang DW, Dai XY, Yin WD, Tang CK. | 08/15/2020 |
| KLF14 inhibits the inflammatory response in endothelial cells; its protective effects are mediated by transcriptional inhibition of NF-kappaB p65 | Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-κB signaling pathway.
Hu W, Lu H, Zhang J, Fan Y, Chang Z, Liang W, Wang H, Zhu T, Garcia-Barrio MT, Peng D, Chen YE, Guo Y., Free PMC Article | 11/23/2019 |
| overexpression protective of immune-mediated liver damage | Overexpression of KLF14 protects against immune-mediated hepatic injury in mice.
Chen X, Tan Q, Wang Y, Lv H, Wang Z, Lin Z, Du Z, Xiong S, Han J, Tian D, Wang B. | 07/20/2019 |
| these data provide proof of concept that deregulation of KLF14/PLK1 cascade plays a key role in thrombin-induced endothelial dysfunction in type 2 diabetes mellitus | Stimulation of KLF14/PLK1 pathway by thrombin signaling potentiates endothelial dysfunction in Type 2 diabetes mellitus.
Hao JS, Zhu CJ, Yan BY, Yan CY, Ling R. | 09/22/2018 |
| DNA methylation at Klf14 regulated mRNA expressions, which were downstream and inflammation genes in the adipose tissue. The methylation level of KLF14 supposed to predict inflammatory change in the adipose tissue as epigenetic biomarker in the whole blood. | DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue.
Iwaya C, Kitajima H, Yamamoto K, Maeda Y, Sonoda N, Shibata H, Inoguchi T. | 03/31/2018 |
| Klf14 is not expressed in adult liver and its deletion does not affect plasma HDL-cholesterol concentration and other diet-induced obesity phenotypes in male mice. Klf14 is highly expressed in mouse adenohypophysis and KLF14 loss of function impacts on the pituitary transcriptome. | Germline deletion of Krüppel-like factor 14 does not increase risk of diet induced metabolic syndrome in male C57BL/6 mice.
Argmann CA, Violante S, Dodatko T, Amaro MP, Hagen J, Gillespie VL, Buettner C, Schadt EE, Houten SM., Free PMC Article | 10/10/2017 |
| These data demonstrate an important role for KLF14 expression in atherosclerotic lesion formation. | A novel role for the Krüppel-like factor 14 on macrophage inflammatory response and atherosclerosis development.
Wei X, Yang R, Wang C, Jian X, Li L, Liu H, Yang G, Li Z. | 03/25/2017 |
| KLF14 reduction serves as a mechanism leading to centrosome amplification and tumorigenesis. On the other hand, forced expression of KLF14 leads to mitotic catastrophe. | Loss of KLF14 triggers centrosome amplification and tumorigenesis.
Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Hou Z, Cui Y, Cao L, Li X, Zhang S, Wang C., Free PMC Article | 05/7/2016 |
| KLF14 is dysregulated in the liver of 2 dyslipidemia mouse models. KLF14 regulates plasma HDL-C levels and cholesterol efflux capacity by modulating hepatic ApoA-I production. Hepatic-specific Klf14 deletion in mice decreased circulating HDL-C levels. | Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.
Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE., Free PMC Article | 01/16/2016 |
| This is the first description of the activity and mechanisms underlying the function of KLF14 as an activator protein and novel regulator of lipid signaling. | New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids.
de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH., Free PMC Article | 10/11/2014 |
| The presence of progesterone induced the gene expression of egr-1 and also KLF14, indicating that this steroid channels the signaling pathway into a non-canonical mechanism. | Involvement of KLF14 and egr-1 in the TGF-beta1 action on Leydig cell proliferation.
Gonzalez CR, Vallcaneras SS, Calandra RS, Gonzalez Calvar SI. | 07/27/2013 |
| KLF14 gene is intronless, and is monoallelically expressed from the maternal allele in both human and mouse. | Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.
Parker-Katiraee L, Carson AR, Yamada T, Arnaud P, Feil R, Abu-Amero SN, Moore GE, Kaneda M, Perry GH, Stone AC, Lee C, Meguro-Horike M, Sasaki H, Kobayashi K, Nakabayashi K, Scherer SW., Free PMC Article | 12/7/2010 |