| Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer. | Let-7a inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer.
Li B, Chen P, Chang Y, Qi J, Fu H, Guo H. | 06/3/2017 |
| RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. | MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma.
Zhou J, Zhang Y, Qi Y, Yu D, Shao Q, Liang J. | 03/25/2017 |
| The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery. | Inhibition of rhotekin exhibits antitumor effects in lung cancer cells.
Zhang W, Liang Z, Li J., Free PMC Article | 12/31/2016 |
| RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2/3/5, CDK1/2 and PCNA | Effect of RTKN on progression and metastasis of colon cancer in vitro.
Qu GQ, Lu YM, Liu YF, Liu Y, Chen WX, Liao XH, Kong WM. | 06/11/2016 |
| suggest that interaction of S100A4 and Rhotekin permits S100A4 to complex with RhoA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea | Coupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells.
Chen M, Bresnick AR, O'Connor KL., Free PMC Article | 10/26/2013 |
| Protein kinase D regulates RhoA activity via phosphorylation rhotekin at Ser-435. | Protein kinase D regulates RhoA activity via rhotekin phosphorylation.
Pusapati GV, Eiseler T, Rykx A, Vandoninck S, Derua R, Waelkens E, Van Lint J, von Wichert G, Seufferlein T., Free PMC Article | 06/16/2012 |
| Loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN. | miR-145 inhibits breast cancer cell growth through RTKN.
Wang S, Bian C, Yang Z, Bo Y, Li J, Zeng L, Zhou H, Zhao RC. | 01/21/2010 |
| Rhotekin forms a complex with vinexin and may play a role at focal adhesions. | Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin.
Nagata K, Ito H, Iwamoto I, Morishita R, Asano T. | 01/21/2010 |
| SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling | SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K. | 01/21/2010 |
| overexpression may play a key role in gastric tumorigenesis by conferring cells resistance to apoptosis | Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis.
Liu CA, Wang MJ, Chi CW, Wu CW, Chen JY. | 01/21/2010 |
| These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy. | Association between clinical characteristics and expression abundance of RTKN gene in human bladder carcinoma tissues from Chinese patients.
Fan J, Ma LJ, Xia SJ, Yu L, Fu Q, Wu CQ, Huang XH, Jiang JM, Tang XD. | 01/21/2010 |
| Lin-7B is a binding partner for Rhotekin in the human brain cDNA library | Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.
Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K. | 01/21/2010 |
| Rho/RTKN-mediated NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis. | Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma.
Liu CA, Wang MJ, Chi CW, Wu CW, Chen JY. | 01/21/2010 |