| Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway. | Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway.
Meng X, Li D, Kan R, Xiang Y, Pan L, Guo Y, Yu P, Luo P, Zou H, Huang L, Zhu Y, Mao B, He Y, Xie L, Xu J, Liu X, Li W, Chen Y, Zhu S, Yang Y, Yu X., Free PMC Article | 09/12/2024 |
| ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation. | ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation.
Feng Y, Luo S, Fang C, Ma S, Fan D, Chen Y, Chen Z, Zheng X, Tang Y, Duan X, Liu X, Ruan X, Guo X., Free PMC Article | 09/6/2024 |
| Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling. | Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling.
Ghosh A, Leung YH, Yu J, Sladek R, Chénier I, Oppong AK, Peyot ML, Madiraju SRM, Al-Khairi I, Thanaraj TA, Abubaker J, Al-Mulla F, Prentki M, Abu-Farha M. | 03/14/2024 |
| Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner. | Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner.
Meng M, Cao Y, Qiu J, Shan G, Wang Y, Zheng Y, Guo M, Yu J, Ma Y, Xie C, Hu C, Xu L, Mueller E, Ma X. | 02/8/2024 |
| Investigation of the relationship between betatrophin and certain key enzymes involved in carbohydrate and lipid metabolism in insulin-resistant mice. | Investigation of the relationship between betatrophin and certain key enzymes involved in carbohydrate and lipid metabolism in insulin-resistant mice.
Arikan FB, Ulas M, Ustundag Y, Boyunaga H, Badem ND. | 11/1/2023 |
| ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE-/- mice. | ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE-/- mice.
Yu H, Jiao X, Yang Y, Lv Q, Du Z, Li L, Hu C, Du Y, Zhang J, Li F, Sun Q, Wang Y, Chen D, Zhang X, Qin Y., Free PMC Article | 08/10/2023 |
| LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis. | LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.
Li DP, Huang L, Kan RR, Meng XY, Wang SY, Zou HJ, Guo YM, Luo PQ, Pan LM, Xiang YX, Mao BB, Xie YY, Wang ZH, Yang M, He R, Yang Y, Liu ZL, Xie JH, Ma DL, Zhang BP, Shao SY, Chen X, Xu SM, He WT, Li WJ, Chen Y, Yu XF., Free PMC Article | 07/27/2023 |
| ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways. | ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways.
Zhang Z, Yuan Y, Hu L, Tang J, Meng Z, Dai L, Gao Y, Ma S, Wang X, Yuan Y, Zhang Q, Cai W, Ruan X, Guo X., Free PMC Article | 05/4/2023 |
| Angiopoietin-like protein 8 deficiency attenuates thoracic aortic aneurysm/dissection development in beta-aminopropionitrile monofumarate-induced model mice. | Angiopoietin-like protein 8 deficiency attenuates thoracic aortic aneurysm/dissection development in β-aminopropionitrile monofumarate-induced model mice.
Yang YY, Jiao XL, Yu HH, Li LY, Li J, Zhang XP, Qin YW. | 12/31/2022 |
| ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition. | ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition.
Tang J, Ma S, Gao Y, Zeng F, Feng Y, Guo C, Hu L, Yang L, Chen Y, Zhang Q, Yuan Y, Guo X., Free PMC Article | 09/3/2022 |
| ANGPTL8 is a negative regulator in pathological cardiac hypertrophy. | ANGPTL8 is a negative regulator in pathological cardiac hypertrophy.
Hu L, Wei J, Zhang Y, Wang Z, Tang J, Tang J, Gao Y, Zhang X, Li Y, Liu Y, Ma S, Guo X, Zhang Q., Free PMC Article | 07/30/2022 |
| Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8. | Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8.
Sylvers-Davie KL, Segura-Roman A, Salvi AM, Schache KJ, Davies BSJ., Free PMC Article | 03/26/2022 |
| Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment. | Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment.
Arefanian H, Al-Khairi I, Khalaf NA, Cherian P, Kavalakatt S, Madhu D, Mathur A, Qaddoumi MG, Al-Mulla F, Abubaker J, Abu-Farha M., Free PMC Article | 02/26/2022 |
| Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells. | Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells.
Bai Y, Du Q, Zhang L, Li L, Wang N, Wu B, Li P, Li L., Free PMC Article | 12/25/2021 |
| Angiopoietin-like protein 8 accelerates atherosclerosis in ApoE(-/)(-) mice. | Angiopoietin-like protein 8 accelerates atherosclerosis in ApoE(-/)(-) mice.
Jiao X, Yang Y, Li L, Yu H, Yang Y, Li J, Du Y, Zhang J, Hu C, Qin Y. | 08/7/2021 |
| Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea. | Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea.
Yang YY, Yu HH, Jiao XL, Li LY, Du YH, Li J, Lv QW, Zhang HN, Zhang J, Hu CW, Zhang XP, Wei YX, Qin YW. | 07/3/2021 |
| Betatrophin knockdown induces beiging and mitochondria biogenesis of white adipocytes. | Betatrophin knockdown induces beiging and mitochondria biogenesis of white adipocytes.
Liao ZZ, Qi XY, Wang YD, Li JY, Gu QQ, Hu C, Hu Y, Sun H, Ran L, Yang J, Liu JH, Xiao XH. | 10/24/2020 |
| These data show that ANGPTL8 plays important metabolic roles in mice that extend beyond triglyceride metabolism. The finding that insulin, glucose, and AMPK signaling regulate Angptl8 expression may provide important clues about the distinct function of ANGPTL8 in these tissues. | Regulation of ANGPTL8 in liver and adipose tissue by nutritional and hormonal signals and its effect on glucose homeostasis in mice.
Zhang L, Shannon CE, Bakewell TM, Abdul-Ghani MA, Fourcaudot M, Norton L. | 08/1/2020 |
| Results suggest that glycine N-methyltransferase (GNMT) might be involved in insulin-induced angiopoietin-like protein 8 (Angptl8) expression in high fat diet (HFD)-mediated metabolic syndrome. | Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice.
Huang JW, Chen CJ, Yen CH, Chen YA, Liu YP., Free PMC Article | 02/8/2020 |
| Study identify Angptl8 as a key regulator hepatokine that resets diurnal rhythms of hepatic clock and metabolic genes in mice. Mechanistically, the resetting function of Angptl8 is dependent on the signal relay of the membrane receptor PirB, phosphorylation of kinases and transcriptional factors, and consequently transient activation of the central clock gene Per1. | Angptl8 mediates food-driven resetting of hepatic circadian clock in mice.
Chen S, Feng M, Zhang S, Dong Z, Wang Y, Zhang W, Liu C., Free PMC Article | 12/14/2019 |
| ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3 | ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.
Haller JF, Mintah IJ, Shihanian LM, Stevis P, Buckler D, Alexa-Braun CA, Kleiner S, Banfi S, Cohen JC, Hobbs HH, Yancopoulos GD, Murphy AJ, Gusarova V, Gromada J., Free PMC Article | 01/20/2018 |
| knock-down of Angptl8 in adipocytes suggests that the protein acts to inhibit intracellular lipolysis, analogous to its activity in the circulation. Depletion of Angptl8 results in an altered cellular phospholipid composition. The findings identify Angptl8 as a central insulin-regulated controller of adipocyte lipid metabolism. | Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition.
Mysore R, Liebisch G, Zhou Y, Olkkonen VM, Nidhina Haridas PA. | 11/4/2017 |
| The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition. | Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth.
Martinez-Perez B, Ejarque M, Gutierrez C, Nuñez-Roa C, Roche K, Vila-Bedmar R, Ballesteros M, Redondo-Angulo I, Planavila A, Villarroya F, Vendrell J, Fernández-Veledo S, Megía A. | 07/1/2017 |
| Obesity is associated with increased betatrophin suppression after an oral glucose load; this response appears to be driven by hyperglycemia. Data suggest that insulin or low glucose (as in hypoglycemia) increases betatrophin expression/secretion in adipocytes (3T3-L1 cells here); elevation of glucose levels blunts this effect. | Weight Loss Partially Restores Glucose-Driven Betatrophin Response in Humans.
Maurer L, Brachs S, Decker AM, Brachs M, Leupelt V, Jumpertz von Schwartzenberg R, Ernert A, Bobbert T, Krude H, Spranger J, Mai K. | 06/3/2017 |
| circulating betatrophin is increased in mice and humans with NAFLD and its expression was induced by endoplasmic reticulum stress in hepatocytes | Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies.
Lee YH, Lee SG, Lee CJ, Kim SH, Song YM, Yoon MR, Jeon BH, Lee JH, Lee BW, Kang ES, Lee HC, Cha BS., Free PMC Article | 04/1/2017 |