| Association between functional genetic variants in retinoid X receptor-alpha/gamma and the risk of gestational diabetes mellitus in a southern Chinese population. | Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.
Yu XY, Song LP, Zheng HT, Wei SD, Wen XL, Huang B, Liu DB., Free PMC Article | 02/5/2022 |
| Association between Single-nucleotide Polymorphisms of RXRG and Genetic Susceptibility to Type 2 Diabetes in South China. | Association between Single-nucleotide Polymorphisms of RXRG and Genetic Susceptibility to Type 2 Diabetes in South China.
Yu H, Wang S, Hu W, Xu L, Ding Y, Kong D, Pan H. | 08/7/2021 |
| Using a progression model of epithelial ovarian cancer (EOC), a proteomics-based approach identified a specific loss of RXR-gamma driving the progression of EOC. | Proteomics to Predict Loss of RXR-γ During Progression of Epithelial Ovarian Cancer.
Kalra RS, Bapat SA. | 04/4/2020 |
| Findings indicate that Gc globulin (GC) rs16847024, retinoid X receptor gamma (RXRG) rs17429130 and retinoid X receptor alpha (RXRA) rs4917356 were candidate susceptibility markers for gestational diabetes mellitus (GDM) in Chinese females. | Genetic variants in vitamin D signaling pathways and risk of gestational diabetes mellitus.
Shi A, Wen J, Liu G, Liu H, Fu Z, Zhou J, Zhu Y, Liu Y, Guo X, Xu J., Free PMC Article | 02/17/2018 |
| genetic association studies in a population in Brazil: Data suggest that SNPs in RXRG (rs2134095) and GC (rs7041) are associated with low-density lipoprotein cholesterol levels and hypercholesterolemia in the population studied; there was no apparent association with an SNP in VDR (rs2228570). (RXRG = retinoid X receptor gamma; GC = vitamin D-binding protein; VDR = vitamin D receptor) | A vitamin D pathway gene-gene interaction affects low-density lipoprotein cholesterol levels.
Grave N, Tovo-Rodrigues L, da Silveira J, Rovaris DL, Dal Bosco SM, Contini V, Genro JP. | 11/25/2017 |
| Germline mutations in the RXRG gene are linked to Familial isolated pituitary adenoma in a Brazilian Family. | Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
Melo FM, Couto PP, Bale AE, Bastos-Rodrigues L, Passos FM, Lisboa RG, Ng JM, Curran T, Dias EP, Friedman E, De Marco L. | 02/18/2017 |
| Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively. | Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.
Koutsounas I, Giaginis C, Alexandrou P, Zizi-Serbetzoglou A, Patsouris E, Kouraklis G, Theocharis S. | 06/28/2016 |
| Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR. | Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors.
Giner XC, Cotnoir-White D, Mader S, Lévesque D., Free PMC Article | 01/16/2016 |
| Differences in RAR and RXR subtype mRNA expression patterns in various PTCs may contribute to the immunochemistry data available, and may thus find exploitation in clinical oncology, particularly in the differential diagnosis of thyroid neoplasms. | mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma.
Macejová D, Galbavý S, Podoba J, Bialešová L, Brtko J. | 04/12/2014 |
| loss of RXR-gamma levels appears to provide mechanistic benefits to transformed cells towards the acquisition of resistance to apoptosis hallmark of cancer | Expression proteomics predicts loss of RXR-γ during progression of epithelial ovarian cancer.
Kalra RS, Bapat SA., Free PMC Article | 04/5/2014 |
| Genetic variation in RXRgamma gene may contribute to the development of HIVLD in combination antiretroviral therapy treated HIV patients. | RXRγ gene variants are associated with HIV lipodystrophy.
Pushpakom SP, Owen A, Back DJ, Pirmohamed M. | 01/11/2014 |
| The RXR-gamma rs3818569 single nucleotide polymorphisms is associated with diabetic retinopathy development in the Taiwanese population. | Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy.
Hsieh CH, Pei D, Hung YJ, Hsiao FC. | 09/8/2012 |
| results indicate that RXR-gamma is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination. | Retinoid X receptor gamma signaling accelerates CNS remyelination.
Huang JK, Jarjour AA, Nait Oumesmar B, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Baron-Van Evercooren A, Chambon P, Ffrench-Constant C, Franklin RJM., Free PMC Article | 02/5/2011 |
| RXRgamma and PPARgamma ligands acted synergistically to inhibit proliferation and invasiveness in colon cancer cells. | RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells.
Papi A, Rocchi P, Ferreri AM, Orlandi M. | 10/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| methylation-associated downregulation of the RXRG gene may play a differential role in the carcinogenesis of non-small cell lung cancer (NSCLC) according to smoking status. | Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features.
Lee SM, Lee JY, Choi JE, Lee SY, Park JY, Kim DS. | 02/22/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).
Le Clerc S, Limou S, Coulonges C, Carpentier W, Dina C, Taing L, Delaneau O, Labib T, Sladek R, ANRS Genomic Group, Deveau C, Guillemain H, Ratsimandresy R, Montes M, Spadoni JL, Therwath A, Schächter F, Matsuda F, Gut I, Lelièvre JD, Lévy Y, Froguel P, Delfraissy JF, Hercberg S, Zagury JF. | 12/2/2009 |
| These data indicate that the RAR/RXR heterodimer is a critical regulator of human hematopoietic stem cell (HSC) differentiation, and pharmacological modulation of RXR signaling prevents the loss of human HSCs that otherwise occurs in short-term culture. | Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.
Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Type 2 diabetes susceptibility genes on chromosome 1q21-24.
Hasstedt SJ, Chu WS, Das SK, Wang H, Elbein SC. | 04/3/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (9) articlesCommon genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.
Peloso GM, Demissie S, Collins D, Mirel DB, Gabriel SB, Cupples LA, Robins SJ, Schaefer EJ, Brousseau ME. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.
Cheung CL, Chan BY, Chan V, Ikegawa S, Kou I, Ngai H, Smith D, Luk KD, Huang QY, Mori S, Sham PC, Kung AW. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers.
Doecke JD, Zhao ZZ, Stark MS, Green AC, Hayward NK, Montgomery GW, Webb PM, Whiteman DC, Australian Cancer Study. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases.
Feng J, Chen J, Yan J, Jones IR, Craddock N, Cook EH Jr, Goldman D, Heston LL, Sommer SS. | 03/13/2008 |
| Single nucleotide polymorphism not a factor in resistance to thyroid hormone. | Search for genetic variants in the retinoid X receptor-gamma-gene by polymerase chain reaction-single-strand conformation polymorphism in patients with resistance to thyroid hormone without mutations in thyroid hormone receptor beta gene.
Romeo S, Menzaghi C, Bruno R, Sentinelli F, Fallarino M, Fioretti F, Filetti S, Balsamo A, Di Mario U, Baroni MG. | 01/21/2010 |
| These results show that the stimulation of ASCT2 expression in response to glutamine in part involves binding of FXR/RXR to the ASCT2 promoter. | Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers.
Bungard CI, McGivan JD. | 01/21/2010 |
| RXRalpha and RXRgamma immunodetected in all normal, nodular, and basal cell hyperplasia, as well as carcinomatous prostates. In atrophic glands, the expression of both receptors was found in 22.5% of samples. | Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.
Alfaro JM, Fraile B, Lobo MV, Royuela M, Paniagua R, Arenas MI. | 01/21/2010 |
| Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression may have roles in apoptosis of thyroid carcinoma | Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment.
Klopper JP, Hays WR, Sharma V, Baumbusch MA, Hershman JM, Haugen BR. | 01/21/2010 |
| RXRgamma contributes to the genetic background of familial combined hyperlipidemia. | High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
Nohara A, Kawashiri MA, Claudel T, Mizuno M, Tsuchida M, Takata M, Katsuda S, Miwa K, Inazu A, Kuipers F, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H. | 01/21/2010 |