| Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B. | Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B.
Ghate A, Uhlig HH. | 10/10/2023 |
| Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. | Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M, International IBD Genetics Consortium, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS., Free PMC Article | 10/10/2023 |
| Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection. | Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection.
Tsiftsoglou SA, Gavriilaki E, Touloumenidou T, Koravou EE, Koutra M, Papayanni PG, Karali V, Papalexandri A, Varelas C, Chatzopoulou F, Chatzidimitriou M, Chatzidimitriou D, Veleni A, Rapti E, Kioumis I, Kaimakamis E, Bitzani M, Boumpas DT, Tsantes A, Sotiropoulos D, Papadopoulou A, Sakellari I, Kokoris S, Anagnostopoulos A., Free PMC Article | 03/8/2023 |
| Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese. | Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese.
Shi DC, Feng SZ, Zhong Z, Cai L, Wang M, Fu DY, Yu XQ, Li M., Free PMC Article | 11/5/2022 |
| Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy. | Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy.
Ji FP, Wen L, Zhang YP, Liu EP, Wen JG. | 05/14/2022 |
| The prognostic value of plasma complement factor B (CFB) in thyroid carcinoma. | The prognostic value of plasma complement factor B (CFB) in thyroid carcinoma.
Wu P, Shi J, Sun W, Zhang H., Free PMC Article | 02/19/2022 |
| A small fragment of factor B as a potential inhibitor of complement alternative pathway activity. | A small fragment of factor B as a potential inhibitor of complement alternative pathway activity.
Sultan EY, Rizk DE, Kenawy HI, Hassan R. | 01/29/2022 |
| Inherited Kidney Complement Diseases. | Inherited Kidney Complement Diseases.
Lemaire M, Noone D, Lapeyraque AL, Licht C, Frémeaux-Bacchi V., Free PMC Article | 01/22/2022 |
| Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer. | Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer.
Shimazaki R, Takano S, Satoh M, Takada M, Miyahara Y, Sasaki K, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Sogawa K, Motohashi S, Nomura F, Miyazaki M, Ohtsuka M., Free PMC Article | 01/15/2022 |
| Association of genetic variants rs641153 (CFB), rs2230199 (C3), and rs1410996 (CFH) with age-related macular degeneration in a Brazilian population. | Association of genetic variants rs641153 (CFB), rs2230199 (C3), and rs1410996 (CFH) with age-related macular degeneration in a Brazilian population.
Neto JM, Viturino MG, Ananina G, Bajano FF, Costa SMDS, Roque AB, Borges GF, Franchi R, Rim PH, Medina FM, Costa FF, Melo MB, de Vasconcellos JP., Free PMC Article | 12/18/2021 |
| Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. | Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
Xu X, Zhang C, Denton DT, O'Connell D, Drolet DW, Geisbrecht BV., Free PMC Article | 07/24/2021 |
| Complement component factor B has thrombin-like activity. | Complement component factor B has thrombin-like activity.
Takahashi K, Banda NK, Holers VM, Van Cott EM., Free PMC Article | 07/3/2021 |
| Detection of C3 Nephritic Factor by Hemolytic Assay. | Detection of C3 Nephritic Factor by Hemolytic Assay.
Chabannes M, Frémeaux-Bacchi V, Chauvet S. | 06/26/2021 |
| Detection of Complement Factor B Autoantibodies by ELISA. | Detection of Complement Factor B Autoantibodies by ELISA.
Józsi M, Uzonyi B. | 06/26/2021 |
| Role of complement factor B rs4151667 (L9H) polymorphisms and its interactional role with CFH Y402H and C3 rs2230199 (R102G) risk variants in age-related macular degeneration: a case control study. | Role of complement factor B rs4151667 (L9H) polymorphisms and its interactional role with CFH Y402H and C3 rs2230199 (R102G) risk variants in age-related macular degeneration: a case control study.
Roshanipour N, Laleh MG, Bonyadi M, Bonyadi MHJ, Soheilian M, Javadzadeh A, Yaseri M., Free PMC Article | 06/19/2021 |
| A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population. | A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population.
Seo JY, Shin JG, Youn BJ, Namgoong S, Cheong HS, Kim LH, Kim JO, Shin HD, Kim YJ., Free PMC Article | 01/9/2021 |
| we demonstrated that the complement factor B genes rs641153 and rs4151667, but not rs1048709, rs2072633, rs12614, were associated with the susceptibility of age-related macular degeneration and might play predictive roles in future age-related macular degeneration diagnosis. | Complement factor B gene polymorphisms and risk of age-related macular degeneration: A meta-analysis.
Su Y, Hu Z, Pan T, Chen L, Xie P, Liu Q. | 08/1/2020 |
| Serum levels of C1q, Bb, and H should be studied further as potential diagnostic markers for severe pre-eclampsia. | Serum Levels of Complement Factors C1q, Bb, and H in Normal Pregnancy and Severe Pre-Eclampsia.
Jia K, Ma L, Wu S, Yang W., Free PMC Article | 02/8/2020 |
| Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays. | Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays.
Urban A, Borowska A, Felberg A, van den Heuvel L, Stasiłojć G, Volokhina E, Okrój M. | 08/17/2019 |
| Preoperative plasma CFB can be used to predict the prognosis of resectable pancreatic cancers; it outperforms both CA 19-9 and CEA. | Prognostic potential of the preoperative plasma complement factor B in resected pancreatic cancer: A pilot study.
Kim SH, Lee MJ, Hwang HK, Lee SH, Kim H, Paik YK, Kang CM. | 08/10/2019 |
| The pooled ORs for rs551397, rs2274700, rs4151667, rs641153, rs1047286, rs9332739, and rs547154 in the heterozygote model were 0.53, 0.53 , 0.54, 0.48, 1.42, 0.50, and 0.52, respectively. We confirmed the protective role of C2/CFB/CFH polymorphisms in the development of Age-Related Macular Degeneration (AMD), and showed single nucleotide polymorphism in C3 was a high-risk factor for AMD | Association Between Complement Factor C2/C3/CFB/CFH Polymorphisms and Age-Related Macular Degeneration: A Meta-Analysis.
Lu F, Liu S, Hao Q, Liu L, Zhang J, Chen X, Hu W, Huang P. | 01/5/2019 |
| Study demonstrated that a novel complotype composed of CFB (rs4151667) in combination with CFB (rs641153) and CFH(rs800292) is strongly associated with complement activation and age-related macular degeneration status. | A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.
Paun CC, Lechanteur YTE, Groenewoud JMM, Altay L, Schick T, Daha MR, Fauser S, Hoyng CB, den Hollander AI, de Jong EK., Free PMC Article | 05/19/2018 |
| target sequencing of age-related macular degeneration (AMD) susceptibility genes identified enrichment of low-frequency coding variants in CETP, C2 and CFB are associated with AMD susceptibility in the Japanese population | Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.
Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, Oshima Y, Mori R, Tanaka K, Mori K, Inoue S, Terasaki H, Yasuma T, Honda S, Miki A, Inoue M, Fujisawa K, Takahashi K, Yasukawa T, Yanagi Y, Kadonosono K, Sonoda KH, Ishibashi T, Takahashi A, Kubo M. | 03/24/2018 |
| Heterozygous variants in the CFB gene can be pathogenic and associated with immune-complex diffuse membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome | Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab.
Alfakeeh K, Azar M, Alfadhel M, Abdullah AM, Aloudah N, Alsaad KO. | 03/10/2018 |
| The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control. | Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia.
He Y, Xu B, Song D, Yu F, Chen Q, Zhao M. | 12/16/2017 |