| Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery. | Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery.
Liu Z, Wang J, Shi Y, Yee BA, Terrey M, Zhang Q, Lee JC, Lin KI, Wang AH, Ackerman SL, Yeo GW, Cui H, Yang XL., Free PMC Article | 11/2/2023 |
| WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly. | WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly.
Bögershausen N, Krawczyk HE, Jamra RA, Lin SJ, Yigit G, Hüning I, Polo AM, Vona B, Huang K, Schmidt J, Altmüller J, Luppe J, Platzer K, Dörgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, Bültmann E, Nürnberg P, Spielmann M, Lemke JR, Li Y, Zenker M, Varshney GK, Hillen HS, Kratz CP, Wollnik B. | 09/17/2022 |
| Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer. | Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer.
Zhao J, Bai H, Li X, Yan J, Zou G, Wang L, Li X, Liu Z, Xiang R, Yang XL, Shi Y., Free PMC Article | 03/5/2022 |
| Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription. | Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y., Free PMC Article | 05/22/2021 |
| Here, we report on mutations in two aminoacyl-tRNA synthetases that are associated with Intellectual disability (ID) in two unrelated Iranian families. In the first family, we identified a homozygous missense mutation (c.514G>A, p.Asp172Asn) in the cytoplasmic seryl-tRNA synthetase (SARS) gene | Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability.
Musante L, Püttmann L, Kahrizi K, Garshasbi M, Hu H, Stehr H, Lipkowitz B, Otto S, Jensen LR, Tzschach A, Jamali P, Wienker T, Najmabadi H, Ropers HH, Kuss AW. | 02/24/2018 |
| Analyzed the ability of cytosolic SerRS to bind and act on tRNA(Ser), tRNA(Sec), and 10 mutant and chimeric constructs in which elements of tRNA(Ser) were transposed onto tRNA(Sec). We show that SerRS only subtly prefers tRNA(Ser) to tRNA(Sec), and that discrimination occurs at the level of the serylation reaction. | Insights into substrate promiscuity of human seryl-tRNA synthetase.
Holman KM, Puppala AK, Lee JW, Lee H, Simonović M., Free PMC Article | 10/28/2017 |
| Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS) to form a SerRS/YY1 complex which functions as a negative effector to regulate vegfa transcription through binding a distal segment of the vegfa promoter, while NFKB1 serves as a positive effector through outcompeting SerRS/YY1 for binding at the same distal segment. | Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis.
Fu CY, Wang PC, Tsai HJ., Free PMC Article | 08/12/2017 |
| tRNA recognition mode of SerRS. | SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.
Wang C, Guo Y, Tian Q, Jia Q, Gao Y, Zhang Q, Zhou C, Xie W., Free PMC Article | 04/30/2016 |
| Several data support that p.R402H mutation in SARS2 is a new cause of HUPRA syndrome. | A new mutation in the gene encoding mitochondrial seryl-tRNA synthetase as a cause of HUPRA syndrome.
Rivera H, Martín-Hernández E, Delmiro A, García-Silva MT, Quijada-Fraile P, Muley R, Arenas J, Martín MA, Martínez-Azorín F., Free PMC Article | 07/26/2014 |
| A long-range conformational and functional communication specific to higher eukaryotes is found in human SerRS. | Crystal structure of human Seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes.
Xu X, Shi Y, Yang XL., Free PMC Article | 06/28/2014 |
| study identified a nuclear localization signal sequence embedded in UNE-S domain and showed that the essential role of SerRS in vascular development is dependent on UNE-S and its role to mobilize SerRS from the cytoplasm to the nucleus | Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.
Xu X, Shi Y, Zhang HM, Swindell EC, Marshall AG, Guo M, Kishi S, Yang XL., Free PMC Article | 08/4/2012 |
| Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. | Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome.
Belostotsky R, Ben-Shalom E, Rinat C, Becker-Cohen R, Feinstein S, Zeligson S, Segel R, Elpeleg O, Nassar S, Frishberg Y., Free PMC Article | 04/2/2011 |
| Recombinant human cytosolic seryl-tRNA synthetase protein was purified to homogeneity and crystallized. Diffraction data were collected to 3.13 A resolution. | Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase.
Artero JB, Teixeira SC, Mitchell EP, Kron MA, Forsyth VT, Haertlein M., Free PMC Article | 03/26/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
Fontaine-Bisson B, Renström F, Rolandsson O, MAGIC, Payne F, Hallmans G, Barroso I, Franks PW., Free PMC Article | 09/15/2010 |
| SARS regulates endothelial sprouting. These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development. | Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development.
Herzog W, Müller K, Huisken J, Stainier DY., Free PMC Article | 01/21/2010 |