| Hypermethylation of the sodium channel beta subunit gene promoter is associated with colorectal cancer. | Hypermethylation of the sodium channel beta subunit gene promoter is associated with colorectal cancer.
Liu Y, Duan Y, Bai T, Kong D., Free PMC Article | 10/17/2024 |
| SCNN1B regulates the proliferation, migration, and collagen deposition of human lung fibroblasts. | SCNN1B regulates the proliferation, migration, and collagen deposition of human lung fibroblasts.
Yan Y, Zhang Y, Zhang J, Ying L. | 09/28/2023 |
| Genetic variation in salt taste receptors impact salt intake and blood pressure. | Genetic variation in salt taste receptors impact salt intake and blood pressure.
Mohammadifard N, Moazeni F, Azizian-Farsani F, Gharipour M, Khosravi E, Sadeghian L, Mansouri A, Shirani S, Sarrafzadegan N., Free PMC Article | 03/22/2023 |
| Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome. | Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome.
Qu Y, Lu Y, Zhang D, Liu X, Fan P, Chen J, Zhang H, Yang K, Tian T, Zhou Y, Zhang Q, Zhang Y, Wang L, Huang Z, Liu Y, Hu A, Zhou X. | 03/10/2023 |
| The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade. | The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade.
Qian Y, Zhou L, Luk STY, Xu J, Li W, Gou H, Chen H, Kang W, Yu J, Wong CC., Free PMC Article | 02/27/2023 |
| Rare Variants in Genes Encoding Subunits of the Epithelial Na[+] Channel Are Associated With Blood Pressure and Kidney Function. | Rare Variants in Genes Encoding Subunits of the Epithelial Na(+) Channel Are Associated With Blood Pressure and Kidney Function.
Blobner BM, Kirabo A, Kashlan OB, Sheng S, Arnett DK, Becker LC, Boerwinkle E, Carlson JC, Gao Y, Gibbs RA, He J, Irvin MR, Kardia SLR, Kelly TN, Kooperberg C, McGarvey ST, Menon VK, Montasser ME, Naseri T, Redline S, Reiner AP, Reupena MS, Smith JA, Sun X, Vaidya D, Viaud-Martinez KA, Weeks DE, Yanek LR, Zhu X, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium*, Minster RL, Kleyman TR., Free PMC Article | 01/28/2023 |
| Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting. | Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting.
Blaconà G, Raso R, Castellani S, Pierandrei S, Del Porto P, Ferraguti G, Ascenzioni F, Conese M, Lucarelli M., Free PMC Article | 05/14/2022 |
| Consistent Assignment of Risk and Benign Allele at rs2303153 in the CF Modifier Gene SCNN1B in Three Independent F508del-CFTR Homozygous Patient Populations. | Consistent Assignment of Risk and Benign Allele at rs2303153 in the CF Modifier Gene SCNN1B in Three Independent F508del-CFTR Homozygous Patient Populations.
Stanke F, Becker T, Ismer HS, Dunsche I, Hedtfeld S, Kontsendorn J, Dittrich AM, Tümmler B., Free PMC Article | 02/12/2022 |
| A novel nonsense mutation in the beta-subunit of the epithelial sodium channel causing Liddle syndrome. | A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome.
Mareš Š, Filipovský J, Vlková K, Pešta M, Černá V, Hrabák J, Mlíková Seidlerová J, Mayer O. | 11/22/2021 |
| Integrative analyses identified ion channel genes GJB2 and SCNN1B as prognostic biomarkers and therapeutic targets for lung adenocarcinoma. | Integrative analyses identified ion channel genes GJB2 and SCNN1B as prognostic biomarkers and therapeutic targets for lung adenocarcinoma.
Lu A, Shi Y, Liu Y, Lin J, Zhang H, Guo Y, Li L, Lin Z, Wu J, Ji D, Wang C. | 08/7/2021 |
| The SPLUNC1-betaENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia. | The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.
Ahmad S, Kim CSK, Tarran R., Free PMC Article | 06/12/2021 |
| DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes. | DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes.
Pierandrei S, Truglio G, Ceci F, Del Porto P, Bruno SM, Castellani S, Conese M, Ascenzioni F, Lucarelli M., Free PMC Article | 05/15/2021 |
| Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B. | Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B.
Becker T, Pich A, Tamm S, Hedtfeld S, Ibrahim M, Altmüller J, Dalibor N, Toliat MR, Janciauskiene S, Tümmler B, Stanke F., Free PMC Article | 05/15/2021 |
| Premature Stroke Secondary to Severe Hypertension Results from Liddle Syndrome Caused by a Novel SCNN1B Mutation. | Premature Stroke Secondary to Severe Hypertension Results from Liddle Syndrome Caused by a Novel SCNN1B Mutation.
Fan P, Zhang D, Pan XC, Yang KQ, Zhang QY, Lu YT, Zhang Y, Liu XY, Ma WJ, Zhang HM, Song L, Cai J, Liu YX, Zhou XL. | 05/8/2021 |
| Phosphatidylinositol 4,5-bisphosphate directly interacts with the beta and gamma subunits of the sodium channel ENaC. | Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC.
Archer CR, Enslow BT, Carver CM, Stockand JD., Free PMC Article | 01/2/2021 |
| Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption. | Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption.
Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD., Free PMC Article | 10/3/2020 |
| SCNN1B and CA12 play vital roles in occurrence of congenital bilateral absence of vas deferens (CBAVD). | SCNN1B and CA12 play vital roles in occurrence of congenital bilateral absence of vas deferens (CBAVD).
Shen Y, Yue HX, Li FP, Hu FY, Li XL, Wan Q, Zhao WR, Jing JG, Cai DM, Jiang XH., Free PMC Article | 08/13/2020 |
| Four previously unreported beta-ENaC mutations were recorded: E632V and E636V, respectively, among two HT subjects, D638Y in another HT and L628Q in one NT subject. We showed the presence of beta-ENaC polymorphisms among our populace. | Epithelial sodium channel blockade and new β-ENaC polymorphisms among normotensive and hypertensive adult Nigerians.
Elias SO, Sofola OA, Jaja SI. | 06/27/2020 |
| Overexpression of beta-ENaC, in the absence of CFTR dysfunction, increased NLRP3-mediated inflammation, indicating that dysregulated, ENaC-dependent signalling may drive exaggerated inflammatory responses in cystic fibrosis. These data support a role for sodium in modulating NLRP3 inflammasome activation. | ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis.
Scambler T, Jarosz-Griffiths HH, Lara-Reyna S, Pathak S, Wong C, Holbrook J, Martinon F, Savic S, Peckham D, McDermott MF., Free PMC Article | 02/1/2020 |
| Systemic Pseudohypoaldosteronism Type 1 due to 3 Novel Mutations in SCNN1Aand SCNN1BGenes. | Systemic Pseudohypoaldosteronism Type 1 due to 3 Novel Mutations in SCNN1Aand SCNN1BGenes.
Cayir A, Demirelli Y, Yildiz D, Kahveci H, Yarali O, Kurnaz E, Vuralli D, Demirbilek H. | 12/21/2019 |
| SCNN1B was not associated with Salt Sensitivity of Blood Pressure in rare variant analyses. | Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.
Gu X, Gu D, He J, Rao DC, Hixson JE, Chen J, Li J, Huang J, Wu X, Rice TK, Shimmin LC, Kelly TN., Free PMC Article | 11/9/2019 |
| Proteolytic cleavage activates epithelial sodium channel (SCNN) by removal of specific segments in finger domains of alpha and gamma subunits. Data suggest that the lower "palm" domain of SCNN1A is essential for allosteric activation of the SCNN heterotetramer [SCNN1A(1)-SCNN1B-SCNN1A(2)-SCNN1G]. | Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel.
Shobair M, Popov KI, Dang YL, He H, Stutts MJ, Dokholyan NV., Free PMC Article | 01/16/2019 |
| In the present study, the SCNN1G gene was associated with 24-h urinary sodium excretion but was not related to blood pressure. The SCNN1A and SCNN1B genes were not associated with blood pressure either. | Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure.
Yang YJ, Kim J, Kwock CK., Free PMC Article | 11/3/2018 |
| No association was found between single nucleotide polymorphism rs12447134 of sodium channel, nonvoltage-gated 1, beta protein (SCNN1B) gene with the onset of disease hypertension. | [Association of sodium ion transporter gene polymorphisms with essential hypertension among ethnic Koreans from Mudanjiang].
Shi J, Zhang C, Bu X, Han Y, Deng D, Song J. | 06/9/2018 |
| The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations | The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.
Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C., Free PMC Article | 12/9/2017 |