| Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease Therapy. | Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease Therapy.
Sukhanov I, Dorotenko A, Fesenko Z, Savchenko A, Efimova EV, Mor MS, Belozertseva IV, Sotnikova TD, Gainetdinov RR., Free PMC Article | 02/4/2023 |
| cAMP signaling pathway-related proteins, Pde10a and Gnal, may play important roles in the pathogenesis and recovery of mild traumatic brain injury. | Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury.
Song H, Fang S, Gao J, Wang J, Cao Z, Guo Z, Huang Q, Qu Y, Zhou H, Yu J. | 09/15/2018 |
| Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents | Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum.
Wilson JM, Ogden AM, Loomis S, Gilmour G, Baucum AJ 2nd, Belecky-Adams TL, Merchant KM. | 09/3/2016 |
| analysis of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia in the rat model | Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Yang SW, Smotryski J, McElroy WT, Tan Z, Ho G, Tulshian D, Greenlee WJ, Guzzi M, Zhang X, Mullins D, Xiao L, Hruza A, Chan TM, Rindgen D, Bleickardt C, Hodgson R. | 08/4/2012 |
| Dopamine loss inversely regulates PDE10A gene expression in the striatum and PDE10A post-transcription in the nucleus accumbens, therein differentially modulating PDE10A-dependent cyclic AMP catabolism. | PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology.
Giorgi M, Melchiorri G, Nuccetelli V, D'Angelo V, Martorana A, Sorge R, Castelli V, Bernardi G, Sancesario G. | 04/14/2012 |
| Data show that pyridinyl derivatives were less potent than their quinolinyl counterparts, but still exhibited significant PDE10A inhibition potency. | Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.
Andrés JI, De Angelis M, Alcázar J, Iturrino L, Langlois X, Dedeurwaerdere S, Lenaerts I, Vanhoof G, Celen S, Bormans G. | 12/10/2011 |
| The present study is the first to demonstrate a central role of PDE10A in progressive pulmonary vascular remodeling. | Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.
Tian X, Vroom C, Ghofrani HA, Weissmann N, Bieniek E, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS., Free PMC Article | 08/20/2011 |
| The findings presented suggest a role of PDE10A in the adaptation of cyclic nucleotide signaling to daily changes in light intensity in retinal neurons including photoreceptors | Phosphodiesterase10A: abundance and circadian regulation in the retina and photoreceptor of the rat.
Wolloscheck T, Spiwoks-Becker I, Rickes O, Holthues H, Spessert R. | 06/4/2011 |
| We here present, for the first time, the expression of PDE9A, PDE10A, and PDE11A in the trigeminovascular system; localisation indicates that they may have a role in pain pathways | PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system.
Kruse LS, Møller M, Tibaek M, Gammeltoft S, Olesen J, Kruuse C. | 01/21/2010 |
| The expression of Pde10a increases at night in the rat pineal gland >10-fold, where expression is controlled by an adrenergic/cyclic AMP mechanism. | Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC., Free PMC Article | 07/16/2009 |
| Inhibitors of this enzyme such as papaverine increase cortically evoked spike acivity in a dose-dependent manner. | Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation.
Threlfell S, Sammut S, Menniti FS, Schmidt CJ, West AR., Free PMC Article | 01/21/2010 |
| PDE10A is associated with post-synaptic membranes of the medium spiny neurons, suggesting that the specialized compartmentation of PDE10A enables the regulation of intracellular signaling from glutamatergic and dopaminergic inputs to these neurons. | Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase.
Xie Z, Adamowicz WO, Eldred WD, Jakowski AB, Kleiman RJ, Morton DG, Stephenson DT, Strick CA, Williams RD, Menniti FS., Free PMC Article | 01/21/2010 |
| High levels of mRNA are observed in most of the neuronal cell bodies of striatal complex.PDE10A-like immunoreactivity is dense throughout the striatal neuropil, as well as in the internal capsule, globus pallidus, and substantia nigra. | Immunohistochemical localization of PDE10A in the rat brain.
Seeger TF, Bartlett B, Coskran TM, Culp JS, James LC, Krull DL, Lanfear J, Ryan AM, Schmidt CJ, Strick CA, Varghese AH, Williams RD, Wylie PG, Menniti FS. | 01/21/2010 |
| a subset of Pde10A splice variants are up-regulated after long term potentiation induction | Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants.
O'Connor V, Genin A, Davis S, Karishma KK, Doyère V, De Zeeuw CI, Sanger G, Hunt SP, Richter-Levin G, Mallet J, Laroche S, Bliss TV, French PJ. | 01/21/2010 |
| PDE10A proteins, especially PDE10A2, are more abundant in membrane fractions than in cytosolic fractions of striatum | Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation.
Kotera J, Sasaki T, Kobayashi T, Fujishige K, Yamashita Y, Omori K. | 01/21/2010 |