| Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling. | Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling.
Chai L, Wang Q, Wang Y, Li D, Zhang Q, Chen Y, Liu J, Chen H, Qiu Y, Shen N, Wang J, Xie X, Li M. | 09/21/2023 |
| Pdcd4 promotes lipid deposition by attenuating PPARalpha-mediated fatty acid oxidation in hepatocytes. | Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
Du X, Osoro EK, Chen Q, Yan X, Gao D, Wu L, Ren J, Feng L, Wu N, Lu K, Yang X, Zhong B, Han Y, Zhang F, Li D, Lan X, Lu S. | 04/16/2022 |
| Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5. | Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.
Osoro EK, Du X, Liang D, Lan X, Farooq R, Huang F, Zhu W, Ren J, Sadiq M, Tian L, Yang X, Li D, Lu S. | 01/8/2022 |
| Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury. | Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury.
Qi H, Zhang J, Shang Y, Yuan S, Meng C., Free PMC Article | 01/1/2022 |
| PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy. | PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy.
Zhang J, Zhang M, Yang Z, Huang S, Wu X, Cao L, Wang X, Li Q, Li N, Gao F., Free PMC Article | 08/28/2021 |
| LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21. | LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21.
Zhou XH, Chai HX, Bai M, Zhang Z., Free PMC Article | 08/28/2021 |
| Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway. | Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway.
Zhang Q, Cao Y, Liu Y, Huang W, Ren J, Wang P, Song C, Fan K, Ba L, Wang L, Sun H. | 07/3/2021 |
| MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4. | MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4.
Zheng Y, Zhao P, Lian Y, Li S, Chen Y, Li L. | 02/27/2021 |
| PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses. | PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Di Paolo A, Eastman G, Mesquita-Ribeiro R, Farias J, Macklin A, Kislinger T, Colburn N, Munroe D, Sotelo Sosa JR, Dajas-Bailador F, Sotelo-Silveira JR., Free PMC Article | 01/23/2021 |
| MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure. | MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure.
Zhou F, Fu WD, Chen L. | 09/26/2020 |
| Long noncoding RNA TALNEC2 regulates myocardial ischemic injury in H9c2 cells by regulating miR-21/PDCD4-medited activation of Wnt/beta-catenin pathway. | Long noncoding RNA TALNEC2 regulates myocardial ischemic injury in H9c2 cells by regulating miR-21/PDCD4-medited activation of Wnt/β-catenin pathway.
Hao L, Wang J, Liu N. | 08/15/2020 |
| PDCD4 gene silencing can activate the Akt signaling pathway and attenuate vascular endothelial cell injury caused by ischemia-reperfusion in the lower extremities in rats. | Role of Programmed Cell Death 4 (PDCD4)-Mediated Akt Signaling Pathway in Vascular Endothelial Cell Injury Caused by Lower-Extremity Ischemia-Reperfusion in Rats.
Chen H, Zhu H, Yang J, Zhu Y, Mei J, Shen H, Liang K, Zhang X., Free PMC Article | 02/1/2020 |
| The PDCD4-mediated regulation of autophagy was modulated by ATG5. | MiR-208a-3p aggravates autophagy through the PDCD4-ATG5 pathway in Ang II-induced H9c2 cardiomyoblasts.
Wang L, Ye N, Lian X, Peng F, Zhang H, Gong H. | 08/18/2018 |
| PDCD4 is upregulated at the onset of differentiation of L6 mytubes. Myoblasts lacking PDCD4 showed impaired myotube formation. | Depletion of the mRNA translation initiation inhibitor, programmed cell death protein 4 (PDCD4), impairs L6 myotube formation.
Maeda N, Abdullahi A, Beatty B, Dhanani Z, Adegoke OAJ., Free PMC Article | 05/12/2018 |
| miRNA21 overexpression in monolayercultured postnatal rat spinal cord neurons promoted neurite outgrowth and downregulated protein expression levels of PDCD4. | MicroRNA‑21 promotes neurite outgrowth by regulating PDCD4 in a rat model of spinal cord injury.
Jiang Y, Zhao S, Ding Y, Nong L, Li H, Gao G, Zhou D, Xu N., Free PMC Article | 05/5/2018 |
| Overexpression of miR-21 in Mesenchymal stem cells promoted efficacy against chemotherapy-induced premature ovarian failure and its improvement of the repair effect was related to the inhibition of granulosa cell apoptosis by targeting PTEN and PDCD4. | Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis.
Fu X, He Y, Wang X, Peng D, Chen X, Li X, Wang Q., Free PMC Article | 05/5/2018 |
| Findings revealed the role of miR-499-5p in protecting the cardiomyocytes against apoptosis induced by acute myocardial infarction (AMI) via its direct target PDCD4, which providing evidence for the miR-499-5p/PDCD4 pathway as a potential therapeutic target for patients with AMI. | MiR-499-5p protects cardiomyocytes against ischaemic injury via anti-apoptosis by targeting PDCD4.
Li Y, Lu J, Bao X, Wang X, Wu J, Li X, Hong W., Free PMC Article | 01/6/2018 |
| -induced expression of PDCD4 is associated with increased beta cell death. | The role of tumour suppressor PDCD4 in beta cell death in hypoxia.
Kumar S, Marriott CE, Alhasawi NF, Bone AJ, Macfarlane WM., Free PMC Article | 09/30/2017 |
| cardiac progenitor cell-derived exosomal miR-21 had an inhibiting role in the apoptosis pathway through downregulating PDCD4. | Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4.
Xiao J, Pan Y, Li XH, Yang XY, Feng YL, Tan HH, Jiang L, Feng J, Yu XY., Free PMC Article | 09/23/2017 |
| Ischemic postconditioning (IPC)-regulated miR-499 plays an important role in IPC-mediated cardiac protection against myocardial ischemia/reperfusion injury by targeting PDCD4. | Ischemic Postconditioning-Regulated miR-499 Protects the Rat Heart Against Ischemia/Reperfusion Injury by Inhibiting Apoptosis through PDCD4.
Zhu J, Yao K, Wang Q, Guo J, Shi H, Ma L, Liu H, Gao W, Zou Y, Ge J. | 02/18/2017 |
| The apoptosis process enhanced by overexpression of SOX6 or PDCD4, was rescued by the cardiac-abundant miR-499 in rat cardiomyocytes. | SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition.
Jia Z, Wang J, Shi Q, Liu S, Wang W, Tian Y, Lu Q, Chen P, Ma K, Zhou C., Free PMC Article | 10/22/2016 |
| modulation of the NF-kappaB/miR-21/PDCD4 pro-apoptotic pathway by DCA was also shown to occur in the rat liver in vivo. | Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis.
Rodrigues PM, Afonso MB, Simão AL, Borralho PM, Rodrigues CMP, Castro RE., Free PMC Article | 10/1/2016 |
| miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2. | miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2.
Wang J, Jia Z, Zhang C, Sun M, Wang W, Chen P, Ma K, Zhang Y, Li X, Zhou C., Free PMC Article | 01/31/2015 |
| Pdcd4 was up-regulated in lung, spleen, and blood cells from rats with antigen-induced pulmonary inflammation. Pdcd4 expression influenced markers of macrophage alternative activation. RNAi suppressed this and lessened airway remodeling. | Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation.
Zhong B, Yang X, Sun Q, Liu L, Lan X, Tian J, He Q, Hou W, Liu H, Jiang C, Gao N, Lu S. | 01/31/2015 |
| PDCD4 depletion by RNA interference had no significant effect on phenylalanine incorporation into myotube mixed proteins in control cells but further suppressed (30%) this measure in nutrient-deprived cells. | Differential effects of PDCD4 depletion on protein synthesis in myoblast and myotubes.
Kakade D, Islam N, Maeda N, Adegoke OA., Free PMC Article | 07/19/2014 |