| [Role of caspase-8 in stem cell transplantation alleviates rat cerebral cortex apoptosis after cardiopulmonary resuscitation]. | [Role of caspase-8 in stem cell transplantation alleviates rat cerebral cortex apoptosis after cardiopulmonary resuscitation].
Lu E, Zhuo Q, Chen F, Lin Q, Wang X. | 01/14/2023 |
| Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction. | Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction.
Martin S, Harrington DA, Ohlander S, Stupp SI, McVary KT, Podlasek CA., Free PMC Article | 02/12/2022 |
| Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma. | Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma.
Yang X, Zeng Q, Tezel G., Free PMC Article | 01/1/2022 |
| Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation. | Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation.
Wang H, Yu Q, Zhang ZL, Ma H, Li XQ., Free PMC Article | 09/11/2021 |
| Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models. | Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models.
Song Z, Tian X, Shi Q. | 08/21/2021 |
| Kupffer Cell-Derived TNF-alpha Triggers the Apoptosis of Hepatic Stellate Cells through TNF-R1/Caspase 8 due to ER Stress. | Kupffer Cell-Derived TNF-α Triggers the Apoptosis of Hepatic Stellate Cells through TNF-R1/Caspase 8 due to ER Stress.
Wang WM, Xu XS, Miao CM., Free PMC Article | 04/24/2021 |
| Upregulation of miR-133b-5p contributes to hypoxic preconditioning -mediated cardioprotection in cardiomyocytes, and the mechanism may be associated with inhibition of caspase-8 and caspase-3 apoptotic signaling. | miR‑133b‑5p contributes to hypoxic preconditioning‑mediated cardioprotection by inhibiting the activation of caspase‑8 and caspase-3 in cardiomyocytes.
Pan YL, Han ZY, He SF, Yang W, Cheng J, Zhang Y, Chen ZW., Free PMC Article | 09/29/2018 |
| The pattern of Notch2, Numb, and Casp8 gene expression in prefrontal cortex, hippocampus, and cerebellum of the rat brain during formation of spatial memory has been reported. | Pattern of Notch2, Numb, and Cas8 Gene Expression in Relevant Structures of the Rat Brain during Formation of Spatial Memory.
Gruden' MA, Storozheva ZI, Ratmirov AM, Sherstnev VV. | 06/16/2018 |
| results confirm a unique role for the caspase-8 and caspase-9 mediated signal cascade in the differentiation of PC12 cells | Activation of caspase-8 and caspase-9 are required for PC12 cells differentiation.
Mogi M, Kondo A. | 02/13/2016 |
| Co-culture with bone marrow stromal cells protects PC12 neurons from TNF-alpha-induced apoptosis by inhibiting the TNFR1/caspase 8 signaling pathway. | Co-culture with bone marrow stromal cells protects PC12 neuronal cells from tumor necrosis factor-α-induced apoptosis by inhibiting the tumor necrosis factor receptor/caspase signaling pathway.
Li L, Wang J, Tang L, Yu X, Sui Y, Zhang C. | 01/16/2016 |
| Hepatocyte apoptosis could promote NAFLD progression; Fas, FasL, and Caspase-8 mRNA activation were important contributing factors to NAFLD. The upregulation of Bax and Bcl-2 expression might be one important mechanism of the apoptosis in NAFLD. | Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis.
Li CP, Li JH, He SY, Li P, Zhong XL. | 02/14/2015 |
| Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1beta production in acute glaucoma. | Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma.
Chi W, Li F, Chen H, Wang Y, Zhu Y, Yang X, Zhu J, Wu F, Ouyang H, Ge J, Weinreb RN, Zhang K, Zhuo Y., Free PMC Article | 11/8/2014 |
| These results suggest that TRAIL inhibits VEGF-induced angiogenesis by increasing caspase-8 activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 activation and endothelial cell cytotoxicity. | TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions.
Na HJ, Hwang JY, Lee KS, Choi YK, Choe J, Kim JY, Moon HE, Kim KW, Koh GY, Lee H, Jeoung D, Won MH, Ha KS, Kwon YG, Kim YM. | 08/23/2014 |
| Dietary Chlorella was found to decrease caspase-8 mediated DNA fragmentation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in colon tissues. | Dietary Chlorella protects against heterocyclic amine-induced aberrant gene expression in the rat colon by increasing fecal excretion of unmetabolized PhIP.
Lee YJ, Hong YJ, Kim JY, Lee KW, Kwon O. | 01/11/2014 |
| activation of caspase-8 in inflamed microglia prevents their death by necroptosis involving RIPK1 | Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia.
Fricker M, Vilalta A, Tolkovsky AM, Brown GC., Free PMC Article | 06/1/2013 |
| Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation. | Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.
Liu L, Qiu W, Wang H, Li Y, Zhou J, Xia M, Shan K, Pang R, Zhou Y, Zhao D, Wang Y., Free PMC Article | 07/14/2012 |
| data suggest that caspase-8 does not become activated through an extrinsic but an "intrinsic/intracellular" apoptotic pathway unleashed by the down-regulation of c-FLIP by c-Myc | Caspase-8, c-FLIP, and caspase-9 in c-Myc-induced apoptosis of fibroblasts.
Järvinen K, Hotti A, Santos L, Nummela P, Hölttä E. | 01/14/2012 |
| TNF-alpha-induced caspase-8 activation leads to leaky RyR2 channels that contribute to myocardial remodeling after ischemia/reperfusion. | Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion.
Fauconnier J, Meli AC, Thireau J, Roberge S, Shan J, Sassi Y, Reiken SR, Rauzier JM, Marchand A, Chauvier D, Cassan C, Crozier C, Bideaux P, Lompré AM, Jacotot E, Marks AR, Lacampagne A., Free PMC Article | 10/22/2011 |
| Compared with the control group, the expression of Fas mRNA and its protein and caspase-8 mRNA and the activity of caspase-8 and caspase-3 of ovary tissues in the rats treated with formaldehyde significantly increased with dose. | [Effect of formaldehyde on expressions of Fas apoptosis pathway-related genes of ovary tissues in female rats].
Peng G, Zhong C, Zhang Q, Xie Y, Gong F. | 06/4/2011 |
| The role of N-acetylcysteine (NAC) in coun oxidative stress & apoptosis inhibition induced by stim with hCG in rat Leydig cells was studied. Caspase-8 expression levels were investigated. | N-acetylcysteine counteracts oxidative stress and prevents hCG-induced apoptosis in rat Leydig cells through down regulation of caspase-8 and JNK.
Aggarwal A, Misro MM, Maheshwari A, Sehgal N, Nandan D. | 02/26/2011 |
| The expression of caspase-8 in injured brain could be detected in 30 min after injury, increased significantly in 3h, reached its apex in 1d after injury, and remained 4d before decreasing. | [Expression of caspase-8 after brain injury from fluid percussion in rats].
Yang J, Wang Y, Chen XG, Peng QY, Li LB, Liu M. | 04/12/2010 |
| mRNA level, protein level and activity of caspase-8 were increased in a dose-dependent manner in livers and lungs of rats after SO(2) inhalation. | Expression of caspase and apoptotic signal pathway induced by sulfur dioxide.
Bai J, Meng Z. | 03/8/2010 |
| Based on the current data, it could be concluded that high glucose-induced apoptosis in PC12 cells is mediated, in part, by activation of caspase-8, -9, and -3 dependent pathways. | Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells.
Sharifi AM, Eslami H, Larijani B, Davoodi J. | 01/21/2010 |
| Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells. | Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells.
Cai CF, Feng L, Wang L, Kong QZ, Zhao YF. | 01/21/2010 |
| CD95L initiates a rapid caspase 8-dependent endosomal acidification | Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.
Reinehr R, Sommerfeld A, Keitel V, Grether-Beck S, Haüssinger D. | 01/21/2010 |