| SEMG1/2 augment energy metabolism of tumor cells. | SEMG1/2 augment energy metabolism of tumor cells.
Shuvalov O, Kizenko A, Petukhov A, Fedorova O, Daks A, Bottrill A, Snezhkina AV, Kudryavtseva AV, Barlev N., Free PMC Article | 04/13/2021 |
| Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract. | Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract.
Sakaguchi D, Miyado K, Iwamoto T, Okada H, Yoshida K, Kang W, Suzuki M, Yoshida M, Kawano N., Free PMC Article | 04/3/2021 |
| The findings demonstrated that the presence of SEMG SNPs increased the frequency of idiopathic male infertility in Chinese-Han population. | Association of semenogelin (SEMG) gene variants in idiopathic male infertility in Chinese-Han population.
Wu J, Dong X, Liu K, Xia Y, Wang X, Shen O, Ding X, Zhang J. | 06/20/2020 |
| The elevated expression of SEMG1 and reduced expression of miR-525-3p are associated with AZS and male infertility | Expressions of miR-525-3p and its target gene SEMG1 in the spermatozoa of patients with asthenozoospermia.
Zhou QZ, Guo XB, Zhang WS, Zhou JH, Yang C, Bian J, Chen MK, Guo WB, Wang P, Qi T, Wang CY, Yang JK, Liu CD., Free PMC Article | 04/4/2020 |
| Data indicate that semenogelin I (Sg I) expression has potential value in predicting renal cell carcinoma (RCC) progression and prognosis, suggesting the use of Sg I as a biomarker for RCC. | Seminal plasma protein in renal cell carcinoma: expression of semenogelin I is a predictor for cancer progression and prognosis.
Zhang S, Fang J, Zhang X, Qin C, Su S, Deng Y, Song Z, Zhang Y, Wang H, Yin C, Wang Z. | 01/3/2015 |
| Peptides from the antimicrobial protein semenogelin I have antibacterial activity. | Identification of novel semenogelin I-derived antimicrobial peptide from liquefied human seminal plasma.
Zhao H, Lee WH, Shen JH, Li H, Zhang Y. | 11/21/2014 |
| EPPIN and SEMG1 rapidly co-evolved in primates | Interacting proteins on human spermatozoa: adaptive evolution of the binding of semenogelin I to EPPIN.
Silva EJ, Hamil KG, O'Rand MG., Free PMC Article | 10/4/2014 |
| SEMG1 was significantly changed in asthenozoosperm, which could be the candidate gene for the development of diagnostic marker and provided the opportunity to further illustrate the biological mechanisms of asthenozoospermia. | SEMG1 may be the candidate gene for idiopathic asthenozoospermia.
Yu Q, Zhou Q, Wei Q, Li J, Feng C, Mao X. | 10/4/2014 |
| Three regions of SEM1(86-107) comprise the amyloid fibril core that enhances HIV-1 infection. | Structural characterization of semen coagulum-derived SEM1(86-107) amyloid fibrils that enhance HIV-1 infection.
French KC, Roan NR, Makhatadze GI., Free PMC Article | 08/9/2014 |
| Interaction analysis identifies semenogelin I fragments as new binding partners of PIP in human seminal plasma | Interaction analysis identifies semenogelin I fragments as new binding partners of PIP in human seminal plasma.
Tomar AK, Sooch BS, Raj I, Singh S, Yadav S. | 05/25/2013 |
| EPPIN's semenogelin I binding site: a contraceptive drug target. | Characterization of EPPIN's semenogelin I binding site: a contraceptive drug target.
Silva EJ, Hamil KG, Richardson RT, O'Rand MG., Free PMC Article | 03/9/2013 |
| Nuclear semenogelin I expression could be a reliable prognosticator in men who undergo radical prostatectomy. | Seminal plasma proteins in prostatic carcinoma: increased nuclear semenogelin I expression is a predictor of biochemical recurrence after radical prostatectomy.
Izumi K, Li Y, Zheng Y, Gordetsky J, Yao JL, Miyamoto H. | 01/26/2013 |
| The proteomes of the type-1 diabetic, type-2 diabetic, and non-diabetic obese patients presented elevated amounts of the same set of one molecular form of semenogelin-1, one form of clusterin, and two forms of lactotransferrin. | Identification of increased amounts of eppin protein complex components in sperm cells of diabetic and obese individuals by difference gel electrophoresis.
Paasch U, Heidenreich F, Pursche T, Kuhlisch E, Kettner K, Grunewald S, Kratzsch J, Dittmar G, Glander HJ, Hoflack B, Kriegel TM., Free PMC Article | 06/2/2012 |
| Peptides released by physiological cleavage of Semg1 and Semg2 form amyloids that enhance HIV infection. | Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.
Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC., Free PMC Article | 05/26/2012 |
| These results suggest the involvement of semenogelins in prostate cancer and their prognostic values in predicting cancer progression after radical prostatectomy. | Expression of semenogelins I and II and its prognostic significance in human prostate cancer.
Canacci AM, Izumi K, Zheng Y, Gordetsky J, Yao JL, Miyamoto H. | 07/30/2011 |
| Spermatozoa interact with semenogelin I in solution in a non-Zn2+-dependent manner, but associate with immobilized semenogelin I only in the presence of Zn2+. | Binding of semenogelin I to intact human spermatozoa studied by flow cytometry and surface plasmon resonance.
Jonsson M, Frohm B, Malm J. | 03/12/2011 |
| Cysteine 239 of rSEMG1 appears to be the critical amino acid for both binding to eppin and inhibiting sperm motility. | Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.
Mitra A, Richardson RT, O'Rand MG., Free PMC Article | 06/14/2010 |
| expressed in 46% of patients with early stage chronic lymphocytic leukemia; potential target for cancer vaccines | SEMG-1 expression in early stage chronic lymphocytic leukemia.
Ahmed SU, Meklat F, Shahriar M, Zhang J, Mastulov S, Giannakouros T, Jewell A, Zhang Y, Lim SH. | 01/21/2010 |
| Semenogelins (Sgs) modifies the membrane structure, indirectly inhibiting motility, and provides suggestions for a therapy for male infertility through selection of a functional sperm population using Sgs. | Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans.
Yoshida K, Krasznai ZT, Krasznai Z, Yoshiike M, Kawano N, Yoshida M, Morisawa M, Tóth Z, Bazsáné ZK, Márián T, Iwamoto T. | 01/21/2010 |
| SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6. | Semenogelin I expression in myeloma cells can be upregulated pharmacologically.
Zhang Y, Wang Z, Zhang J, Farmer B, Lim SH., Free PMC Article | 01/21/2010 |
| antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH | The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
Edström AM, Malm J, Frohm B, Martellini JA, Giwercman A, Mörgelin M, Cole AM, Sørensen OE., Free PMC Article | 01/21/2010 |
| semenogelins I and II were directly cleaved by KLK14. Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity. | Major role of human KLK14 in seminal clot liquefaction.
Emami N, Deperthes D, Malm J, Diamandis EP. | 01/21/2010 |
| The semenogelin-CD52 soluble form is a direct consequence of the liquefaction process in human semen. | The GPI-anchored CD52 antigen of the sperm surface interacts with semenogelin and participates in clot formation and liquefaction of human semen.
Flori F, Ermini L, La Sala GB, Nicoli A, Capone A, Focarelli R, Rosati F, Giovampaola CD. | 01/21/2010 |
| SGI is a novel target for protein S-nitrosylation in spermatozoa. | Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?
Lefièvre L, Chen Y, Conner SJ, Scott JL, Publicover SJ, Ford WC, Barratt CL., Free PMC Article | 01/21/2010 |
| The conformational change induced in semenogelin I by the binding of Zn(2+) may contribute to the ability of this protein to form a gel | Structural properties of semenogelin I.
Malm J, Jonsson M, Frohm B, Linse S. | 01/21/2010 |