| Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis. | Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.
Xu W, Ou W, Feng Y, Xu Q, Yang Y, Cui L, Du P. | 04/21/2023 |
| Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia. | Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia.
de Oliveira Freitas Machado C, Schafranek M, Brüggemann M, Hernández Cañás MC, Keller M, Di Liddo A, Brezski A, Blümel N, Arnold B, Bremm A, Wittig I, Jaé N, McNicoll F, Dimmeler S, Zarnack K, Müller-McNicoll M., Free PMC Article | 02/4/2023 |
| A candidate gene study reveals association between a variant of the SRp55 splicing factor gene and systemic sclerosis. | A candidate gene study reveals association between a variant of the SRp55 splicing factor gene and systemic sclerosis.
Romano E, Rosa I, Fioretto BS, Kosalka-Wegiel J, Sticchi E, Bellando-Randone S, Manetti M, Matucci-Cerinic M. | 10/29/2022 |
| DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. | DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M, Tan M, Li J. | 04/16/2022 |
| Splicing factor SRSF6 mediates pleural fibrosis. | Splicing factor SRSF6 mediates pleural fibrosis.
Liang LM, Xiong L, Cheng PP, Chen SJ, Feng X, Zhou YY, Niu Q, Wang M, Chen Q, Song LJ, Yu F, He XL, Xiang F, Wang X, Ye H, Ma WL., Free PMC Article | 02/19/2022 |
| Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia. | Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.
Zhou Y, Han C, Wang E, Lorch AH, Serafin V, Cho BK, Gutierrez Diaz BT, Calvo J, Fang C, Khodadadi-Jamayran A, Tabaglio T, Marier C, Kuchmiy A, Sun L, Yacu G, Filip SK, Jin Q, Takahashi YH, Amici DR, Rendleman EJ, Rawat R, Bresolin S, Paganin M, Zhang C, Li H, Kandela I, Politanska Y, Abdala-Valencia H, Mendillo ML, Zhu P, Palhais B, Van Vlierberghe P, Taghon T, Aifantis I, Goo YA, Guccione E, Heguy A, Tsirigos A, Wee KB, Mishra RK, Pflumio F, Accordi B, Basso G, Ntziachristos P., Free PMC Article | 12/4/2021 |
| Relative strength of 5' splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA. | Relative strength of 5' splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA.
Choi N, Liu Y, Oh J, Ha J, Ghigna C, Zheng X, Shen H., Free PMC Article | 10/16/2021 |
| The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic beta-cells. | The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.
Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL., Free PMC Article | 09/18/2021 |
| LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM. | LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM.
Zhang F, Wang H, Yu J, Yao X, Yang S, Li W, Xu L, Zhao L., Free PMC Article | 08/14/2021 |
| SRSF6 regulates alternative splicing of genes involved in DNA damage response and DNA repair in HeLa cells. | SRSF6 regulates alternative splicing of genes involved in DNA damage response and DNA repair in HeLa cells.
Yang X, Zhan P, Feng S, Ji H, Tian W, Wang M, Cheng C, Song B., Free PMC Article | 07/24/2021 |
| Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington's disease models. | Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington's disease models.
Mason MA, Gomez-Paredes C, Sathasivam K, Neueder A, Papadopoulou AS, Bates GP., Free PMC Article | 04/24/2021 |
| Data indicate the extent of inter-individual variation in myocardial dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A)-serine and arginine rich splicing factor 6 (SRSF6)-troponin T2, cardiac type protein (TNNT2) expression in the context of Down syndrome. | Comparative analysis of the DYRK1A-SRSF6-TNNT2 pathway in myocardial tissue from individuals with and without Down syndrome.
Quiñones-Lombraña A, Blanco JG., Free PMC Article | 02/29/2020 |
| Results identified SRSF6 protein as one of the factors involved in modulating the splicing of the DDC mutated (c.714+4A>T) transcript. | Antisense oligonucleotides modulate dopa decarboxylase function in aromatic l-amino acid decarboxylase deficiency.
Tsai CR, Lee HF, Chi CS, Yang MT, Hsu CC. | 10/12/2019 |
| SRSF6 functions the important roles in mediating CRC progression through regulating AS, and indacaterol is repositioned as an antitumour drug through targeting SRSF6. | SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.
Wan L, Yu W, Shen E, Sun W, Liu Y, Kong J, Wu Y, Han F, Zhang L, Yu T, Zhou Y, Xie S, Xu E, Zhang H, Lai M. | 01/5/2019 |
| Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator SRP55; SRP55-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM, BAX), JNK signaling, and endoplasmic reticulum stress. (BIM = BCL-2 interacting protein BIM; BAX = apoptosis regulator BAX) | SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival.
Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL., Free PMC Article | 05/26/2018 |
| The recent studies suggest that correcting the SRSF6-driven missplicing and/or microtubule-associated imbalance might be of therapeutic value in Huntington's disease. | Faulty splicing and cytoskeleton abnormalities in Huntington's disease.
Fernández-Nogales M, Santos-Galindo M, Hernández IH, Cabrera JR, Lucas JJ., Free PMC Article | 01/20/2018 |
| LINC01133 inhibits epithelial mesenchymal transformation and metastasis in colorectal neoplasms by directly binding to SRSF6 as a target mimic. | Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6.
Kong J, Sun W, Li C, Wan L, Wang S, Wu Y, Xu E, Zhang H, Lai M. | 07/29/2017 |
| The authors propose that splicing at 3'ss A3 is dependent on binding of the enhancing SR proteins SRSF2 and SRSF6 to the HIV-1 tat ESE and ESE2 sequence. | Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication.
Erkelenz S, Hillebrand F, Widera M, Theiss S, Fayyaz A, Degrandi D, Pfeffer K, Schaal H., Free PMC Article | 12/19/2015 |
| SRSF6 is a regulator of wound healing and tissue homeostasis in skin. | Splicing factor SRSF6 promotes hyperplasia of sensitized skin.
Jensen MA, Wilkinson JE, Krainer AR., Free PMC Article | 04/19/2014 |
| Zinc inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS. | Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS.
Hara H, Takeda T, Yamamoto N, Furuya K, Hirose K, Kamiya T, Adachi T. | 09/14/2013 |
| The splicing factor SRSF6 is an oncoprotein that regulates the proliferation and survival of lung and colon cancer cells. | The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers.
Cohen-Eliav M, Golan-Gerstl R, Siegfried Z, Andersen CL, Thorsen K, Ørntoft TF, Mu D, Karni R. | 04/27/2013 |
| Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion. | Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.
Yin X, Jin N, Gu J, Shi J, Zhou J, Gong CX, Iqbal K, Grundke-Iqbal I, Liu F., Free PMC Article | 11/24/2012 |
| Report upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors. | Evidence for upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors.
Lai F, Jiang CC, Farrelly ML, Zhang XD, Hersey P. | 09/1/2012 |
| SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs. | Inhibition of splicing by serine-arginine rich protein 55 (SRp55) causes the appearance of partially spliced HIV-1 mRNAs in the cytoplasm.
Tranell A, Tingsborg S, Fenyö EM, Schwartz S. | 08/20/2011 |
| Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3. | Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3.
Tranell A, Fenyö EM, Schwartz S., Free PMC Article | 11/6/2010 |